Abstract

The goal of the imaging core is to collect, de-identify, transfer, and store, brain imaging from participating SPOTRIAS subjects, particularly subjects entered into the SPOTRIAS Trials (CLEARER, STOP-IT, and MR Rescue). Dr. Thomas Tomsick will also be the central reviewer for all imaging studies in the CLEARER Trial as he did for the CLEAR Trial. One of the goals of the next five years of this core for all SPOTRIAS Centers is to develop a shared database of de-identified image data, linked to phenotypic and genetic data that can be used by SPOTRIAS network investigators as well as other investigators. Specific goals include: 1. Collect, de-identify, transfer, and store images related to University of Cincinnati directed projects (CLEARER and STOP-IT as well as to collect and transfer images from other SPOTRIAS projects in which DC participates (MR Rescue). 2. Review and record imaging results for all brain imaging done as part of the CLEARER Trial (Dr. Tomsick). 3. Maintain local SPOTRIAS/MR RESCUE imaging workstation. 4. Collaborate with other SPOTRIAS centers to implement a shared imaging database.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS044283-10
Application #
8378739
Study Section
Special Emphasis Panel (ZNS1-SRB-G)
Project Start
Project End
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
10
Fiscal Year
2012
Total Cost
$131,263
Indirect Cost
$43,598

  Institution

Name
University of Cincinnati
Department
Type
DUNS #
041064767
City
Cincinnati
State
OH
Country
United States
Zip Code
45221

  Publications

Lees, Kennedy R; Selim, Magdy H; Molina, Carlos A et al. (2016) Early Versus Late Assessment of Stroke Outcome. Stroke 47:1416-9
Kandadai, Madhuvanthi A; Mukherjee, Prithviraj; Shekhar, Himanshu et al. (2016) Microfluidic manufacture of rt-PA -loaded echogenic liposomes. Biomed Microdevices 18:48
Adeoye, Opeolu; Sucharew, Heidi; Khoury, Jane et al. (2015) Combined Approach to Lysis Utilizing Eptifibatide and Recombinant Tissue-Type Plasminogen Activator in Acute Ischemic Stroke-Full Dose Regimen Stroke Trial. Stroke 46:2529-33
Chaisinanunkul, Napasri; Adeoye, Opeolu; Lewis, Roger J et al. (2015) Adopting a Patient-Centered Approach to Primary Outcome Analysis of Acute Stroke Trials Using a Utility-Weighted Modified Rankin Scale. Stroke 46:2238-43
Adeoye, Opeolu; Sucharew, Heidi; Khoury, Jane et al. (2015) Recombinant tissue-type plasminogen activator plus eptifibatide versus recombinant tissue-type plasminogen activator alone in acute ischemic stroke: propensity score-matched post hoc analysis. Stroke 46:461-4
Kandadai, Madhuvanthi A; Meunier, Jason M; Hart, Kimberley et al. (2015) Plasmin-loaded echogenic liposomes for ultrasound-mediated thrombolysis. Transl Stroke Res 6:78-87
Lu, A; Wagner, K R; Broderick, J P et al. (2014) Administration of S-methyl-L-thiocitrulline protects against brain injuries after intracerebral hemorrhage. Neuroscience 270:40-7
Adeoye, Opeolu; Knight, William A; Khoury, Jane et al. (2014) A matched comparison of eptifibatide plus rt-PA versus rt-PA alone in acute ischemic stroke. J Stroke Cerebrovasc Dis 23:e313-5
Stamova, Boryana; Jickling, Glen C; Ander, Bradley P et al. (2014) Gene expression in peripheral immune cells following cardioembolic stroke is sexually dimorphic. PLoS One 9:e102550
De Los Rios, Felipe; Kleindorfer, Dawn O; Guzik, Amy et al. (2014) Intravenous fibrinolysis eligibility: a survey of stroke clinicians' practice patterns and review of the literature. J Stroke Cerebrovasc Dis 23:2130-2138

Showing the most recent 10 out of 46 publications