Abstract

: The Career Development Core will provide training that fosters the development of new clinician-scientist leaders in the field of acute stroke research.
Core Specific Aim 1 is to provide comprehensive training in acute stroke research to recent residency graduates who demonstrate rich potential for independent research careers.
This Aim will be met by selecting 2 individuals annually during the Award period for subspecialty training in Stroke and Vascular Neurology or the Emergency Medicine of Cerebrovascular Disease. From Stroke Center faculty, School of Public Health offerings, and the UCLA NIH-supported Institutional K30 Graduate Training Program in Translational Research, fellows will receive formal didactic training in acute stroke management, acute stroke clinical trials, quantitative neuroepidemiology, biostatistics, clinical trial design, outcomes research, neurosonology, laboratory models of oxidative stress and excitotoxicity, and primary and secondary stroke prevention.
Core Specific Aim 2 is to provide comprehensive training in acute stroke research to established investigators who are changing the direction of their research careers.
This Aim will be met by including established investigators changing the direction of their research careers among individuals selected for fellowship training in Stroke and Vascular Neurology, or the Emergency Medicine of Cerebrovascular Disease, and by hosting Visiting Postgraduate Scholars for 1-6 month periods.
Core Specific Aim 3 is to encourage the interest of outstanding physicians early in their careers in the field of acute stroke research.
This Aim will be met by providing key training and mentoring to 15-25 medical students, and 40-60 residents in Neurology, Emergency Medicine, Neurosurgery, and Neuroradiology in acute stroke research.
Core Specific Aim 4 is to encourage the interest of outstanding premedical students early in their careers in the field of acute stroke research.
This Aim will be met by providing key training and mentoring to 250 premedical students in acute stroke research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS044378-05
Application #
7553877
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
5
Fiscal Year
2007
Total Cost
$209,791
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Bevers, Matthew B; Battey, Thomas W K; Ostwaldt, Ann-Christin et al. (2018) Apparent Diffusion Coefficient Signal Intensity Ratio Predicts the Effect of Revascularization on Ischemic Cerebral Edema. Cerebrovasc Dis 45:93-100
Lou, Xin; Yu, Songlin; Scalzo, Fabien et al. (2017) Multi-delay ASL can identify leptomeningeal collateral perfusion in endovascular therapy of ischemic stroke. Oncotarget 8:2437-2443
Nael, Kambiz; Knitter, James R; Jahan, Reza et al. (2017) Multiparametric Magnetic Resonance Imaging for Prediction of Parenchymal Hemorrhage in Acute Ischemic Stroke After Reperfusion Therapy. Stroke 48:664-670
Sheth, Sunil A; Jahan, Reza; Levy, Elad I et al. (2016) Rapid learning curve for Solitaire FR stent retriever therapy: evidence from roll-in and randomised patients in the SWIFT trial. J Neurointerv Surg 8:347-52
Vespa, Paul; Hanley, Daniel; Betz, Joshua et al. (2016) ICES (Intraoperative Stereotactic Computed Tomography-Guided Endoscopic Surgery) for Brain Hemorrhage: A Multicenter Randomized Controlled Trial. Stroke 47:2749-2755
Liu, Dezhi; Scalzo, Fabien; Starkman, Sidney et al. (2015) DWI Lesion Patterns Predict Outcome in Stroke Patients with Thrombolysis. Cerebrovasc Dis 40:279-285
Chaisinanunkul, Napasri; Adeoye, Opeolu; Lewis, Roger J et al. (2015) Adopting a Patient-Centered Approach to Primary Outcome Analysis of Acute Stroke Trials Using a Utility-Weighted Modified Rankin Scale. Stroke 46:2238-43
Guluma, Kama Z; Liebeskind, David S; Raman, Rema et al. (2015) Feasibility and Safety of Using External Counterpulsation to Augment Cerebral Blood Flow in Acute Ischemic Stroke-The Counterpulsation to Upgrade Forward Flow in Stroke (CUFFS) Trial. J Stroke Cerebrovasc Dis 24:2596-604
Shi, Zhong-Song; Duckwiler, Gary R; Jahan, Reza et al. (2015) New Cerebral Microbleeds After Mechanical Thrombectomy for Large-Vessel Occlusion Strokes. Medicine (Baltimore) 94:e2180
Yu, Songlin; Liebeskind, David S; Dua, Sumit et al. (2015) Postischemic hyperperfusion on arterial spin labeled perfusion MRI is linked to hemorrhagic transformation in stroke. J Cereb Blood Flow Metab 35:630-7

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