The Neuropathology, Biomarker and Genetics Core C of this new National Institute of Neurological Disorders and Stroke (NINDS) Morris K. Udall Parkinson's Disease Research Center of Excellence (Udall Center) at the University of Pennsylvania School of Medicine (Penn) will acquire, preserve and characterize postmortem brain tissue in addition to biological samples collected antemortem from clinically assessed Parkinson's disease (PD) patients without and with cognitive impairments (CI), executive dysfunction and dementia (PDD) as well as dementia with Lewy body (DLB) patients and controls followed in Core B. PD, PDD and DLB represent a spectrum of overlapping neurodegenerative disorders known as alpha-synucleinopathies that are characterized by prominent filamentous alpha-synuclein (a-syn) aggregates mainly in neurons or their processes that are referred to as Lewy bodies (LBs) and Lewy neurites (LNs), respectively. Since emerging data suggest progression of PD/PDD/DLB could result from the cell-to-cell spread of pathological a-syn strains in the central nervous system followed by progressive neurodegeneration, efforts to understand the progression of PD to CI, executive dysfunction and dementia (Projects I/II) and mechanism of the cell-to- cell spread of pathological a-syn (Projects III/ IV) are the focus of the Penn Udall Center in the renewal period. Core C supports these goals by implementing postmortem diagnostic criteria for PD/PDD/DLB using state-of-the-art methods while also assessing the utility of other antemortem diagnostics including studies of potential PD/PDD/DLB biomarkers and molecular genetic strategies. Thus, Core C will work closely with the other Cores and all of the Projects in the Penn Udall Center to play a critical facilitative role in the mission of this Center by improving current diagnostic methods, and providing samples of thoroughly characterized fresh, unfixed frozen and fixed brain tissues as well as DNA and biofluids to investigators in this and other Udall Centers for research.

Public Health Relevance

of Core C to the Penn Udall Center overall is that it uniquely supports the mission of the Center to elucidate mechanisms of CI, executive dysfunction and dementia in PD/PDD/DLB as well as mechanisms of neurodegeneration in these disorders mediated by a-syn pathologies. By partnering with the Cores/Projects using new approaches to achieve the Center's goals. Core C contributes to elucidating disease mechanisms in PD/PDD/DLB and efforts to develop novel interventions and better diagnostics for these disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS053488-07
Application #
8534826
Study Section
Special Emphasis Panel (ZNS1-SRB-J)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
7
Fiscal Year
2013
Total Cost
$305,712
Indirect Cost
$114,642
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Tropea, Thomas F; Xie, Sharon X; Rick, Jacqueline et al. (2017) APOE, thought disorder, and SPARE-AD predict cognitive decline in established Parkinson's disease. Mov Disord :
Schrag, Anette; Siddiqui, Uzma Faisal; Anastasiou, Zacharias et al. (2017) Clinical variables and biomarkers in prediction of cognitive impairment in patients with newly diagnosed Parkinson's disease: a cohort study. Lancet Neurol 16:66-75
Cousins, Katheryn A Q; Ash, Sharon; Grossman, Murray (2017) Production of verbs related to body movement in amyotrophic lateral sclerosis (ALS) and Parkinson's Disease (PD). Cortex :
Rennert, Lior; Xie, Sharon X (2017) Cox regression model with doubly truncated data. Biometrics :
St John-Williams, Lisa; Blach, Colette; Toledo, Jon B et al. (2017) Targeted metabolomics and medication classification data from participants in the ADNI1 cohort. Sci Data 4:170140
Ash, Sharon; Jester, Charles; York, Collin et al. (2017) Longitudinal decline in speech production in Parkinson's disease spectrum disorders. Brain Lang 171:42-51
Lopez, Alexander M; Weintraub, Daniel; Claassen, Daniel O (2017) Impulse Control Disorders and Related Complications of Parkinson's Disease Therapy. Semin Neurol 37:186-192
Akhtar, Rizwan S; Xie, Sharon X; Chen, Yin J et al. (2017) Regional brain amyloid-? accumulation associates with domain-specific cognitive performance in Parkinson disease without dementia. PLoS One 12:e0177924
Cooper, Christine A; Jain, Nimansha; Gallagher, Michael D et al. (2017) Common variant rs356182 near SNCA defines a Parkinson's disease endophenotype. Ann Clin Transl Neurol 4:15-25
Rutten, Sonja; Vriend, Chris; van der Werf, Ysbrand D et al. (2017) The bidirectional longitudinal relationship between insomnia, depression and anxiety in patients with early-stage, medication-naïve Parkinson's disease. Parkinsonism Relat Disord 39:31-36

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