Abstract

GENETICS, BIOMARKERS, AND NEUROPATHOLOGY (GBN) CORE: ABSTRACT The goal of the GBN Core is to support the efforts of PANUC to understand and treat cognitive impairment (CI) in Parkinson's disease (PD) and models of PD through human and animal studies. GBN provides logistical and analytical support to all four Projects and the Clinical Resource Core of PANUC as well as to linked U01 NS082137, one of ten projects funded by the NIH Parkinson's Disease Biomarker Program (PI: Dr. Zhang, also co-Leader of GBN Core). We will accomplish our goal through the following Specific Aims:
Specific Aim 1. GENETICS: Genotype new Clinical Resource Core participants for entry into Project 3 and Project 4, and validate putative genetic risk factors for CI in the PD Cognitive Genetics Consortium.
Specific Aim 2. CSF BIOMARKERS: Provide analysis of well established biomarkers for PD and Alzheimer's disease using CSF assays routinely performed in the GBN Core.
Specific Aim 3. NEUROPATHOLOGY: Provide expert analysis of tissue samples from Projects and Cores.
Specific Aim 4. DATA MANAGEMENT and STATISTICS: Provide expert data management and statistical support for the Clinical Resource Core and all Projects and analyze the high dimensional data collected in this Core. The GBN Core serves several initiatives in the NIH Blueprint. It uses existing NIH resources, contributes essential materials to NIH repositories, and is highly patient- oriented and translational.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
2P50NS062684-06
Application #
8881525
Study Section
Special Emphasis Panel (ZNS1-SRB-J (07))
Project Start
2008-07-01
Project End
2015-07-31
Budget Start
2014-09-30
Budget End
2015-07-31
Support Year
6
Fiscal Year
2014
Total Cost
$418,116
Indirect Cost
$87,639

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Flanagan, Margaret E; Cholerton, Brenna; Latimer, Caitlin S et al. (2018) TDP-43 Neuropathologic Associations in the Nun Study and the Honolulu-Asia Aging Study. J Alzheimers Dis 66:1549-1558
Gray, Shelly L; Anderson, Melissa L; Hanlon, Joseph T et al. (2018) Exposure to Strong Anticholinergic Medications and Dementia-Related Neuropathology in a Community-Based Autopsy Cohort. J Alzheimers Dis 65:607-616
Moreno, Monica A; Or-Geva, Noga; Aftab, Blake T et al. (2018) Molecular signature of Epstein-Barr virus infection in MS brain lesions. Neurol Neuroimmunol Neuroinflamm 5:e466
Condello, Carlo; Lemmin, Thomas; Stöhr, Jan et al. (2018) Structural heterogeneity and intersubject variability of A? in familial and sporadic Alzheimer's disease. Proc Natl Acad Sci U S A 115:E782-E791
Locke, Timothy M; Soden, Marta E; Miller, Samara M et al. (2018) Dopamine D1 Receptor-Positive Neurons in the Lateral Nucleus of the Cerebellum Contribute to Cognitive Behavior. Biol Psychiatry 84:401-412
Cholerton, Brenna; Johnson, Catherine O; Fish, Brian et al. (2018) Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease. Parkinsonism Relat Disord 50:29-36
Blue, Elizabeth E; Bis, Joshua C; Dorschner, Michael O et al. (2018) Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project. Dement Geriatr Cogn Disord 45:1-17
Houser, Madelyn C; Chang, Jianjun; Factor, Stewart A et al. (2018) Stool Immune Profiles Evince Gastrointestinal Inflammation in Parkinson's Disease. Mov Disord 33:793-804
Wile, Daryl J; Agarwal, Pankaj A; Schulzer, Michael et al. (2017) Serotonin and dopamine transporter PET changes in the premotor phase of LRRK2 parkinsonism: cross-sectional studies. Lancet Neurol 16:351-359
Dublin, Sascha; Walker, Rod L; Gray, Shelly L et al. (2017) Use of Analgesics (Opioids and Nonsteroidal Anti-Inflammatory Drugs) and Dementia-Related Neuropathology in a Community-Based Autopsy Cohort. J Alzheimers Dis 58:435-448

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