GENETICS, BIOMARKERS, AND NEUROPATHOLOGY (GBN) CORE: ABSTRACT The goal of the GBN Core is to support the efforts of PANUC to understand and treat cognitive impairment (CI) in Parkinson's disease (PD) and models of PD through human and animal studies. GBN provides logistical and analytical support to all four Projects and the Clinical Resource Core of PANUC as well as to linked U01 NS082137, one of ten projects funded by the NIH Parkinson's Disease Biomarker Program (PI: Dr. Zhang, also co-Leader of GBN Core). We will accomplish our goal through the following Specific Aims:
Specific Aim 1. GENETICS: Genotype new Clinical Resource Core participants for entry into Project 3 and Project 4, and validate putative genetic risk factors for CI in the PD Cognitive Genetics Consortium.
Specific Aim 2. CSF BIOMARKERS: Provide analysis of well established biomarkers for PD and Alzheimer's disease using CSF assays routinely performed in the GBN Core.
Specific Aim 3. NEUROPATHOLOGY: Provide expert analysis of tissue samples from Projects and Cores.
Specific Aim 4. DATA MANAGEMENT and STATISTICS: Provide expert data management and statistical support for the Clinical Resource Core and all Projects and analyze the high dimensional data collected in this Core. The GBN Core serves several initiatives in the NIH Blueprint. It uses existing NIH resources, contributes essential materials to NIH repositories, and is highly patient- oriented and translational.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZNS1-SRB-J (07))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
United States
Zip Code
Chahine, Lama M; Stern, Matthew B; Chen-Plotkin, Alice (2014) Blood-based biomarkers for Parkinson's disease. Parkinsonism Relat Disord 20 Suppl 1:S99-103
Mata, Ignacio F; Leverenz, James B; Weintraub, Daniel et al. (2014) APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease. JAMA Neurol 71:1405-12
Shi, Min; Liu, Changqin; Cook, Travis J et al. (2014) Plasma exosomal ?-synuclein is likely CNS-derived and increased in Parkinson's disease. Acta Neuropathol 128:639-50
Burdick, Daniel J; Cholerton, Brenna; Watson, G S et al. (2014) People with Parkinson's disease and normal MMSE score have a broad range of cognitive performance. Mov Disord 29:1258-64
Gallardo, Christian M; Darvas, Martin; Oviatt, Mia et al. (2014) Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice. Elife 3:e03781
Halliday, Glenda M; Leverenz, James B; Schneider, Jay S et al. (2014) The neurobiological basis of cognitive impairment in Parkinson's disease. Mov Disord 29:634-50
Darvas, Martin; Henschen, Charles W; Palmiter, Richard D (2014) Contributions of signaling by dopamine neurons in dorsal striatum to cognitive behaviors corresponding to those observed in Parkinson's disease. Neurobiol Dis 65:112-23
Cohen, Rajal G; Klein, Krystal A; Nomura, Mariko et al. (2014) Inhibition, executive function, and freezing of gait. J Parkinsons Dis 4:111-22
Nuytemans, Karen; Inchausti, Vanessa; Beecham, Gary W et al. (2014) Absence of C9ORF72 expanded or intermediate repeats in autopsy-confirmed Parkinson's disease. Mov Disord 29:827-30
Stewart, Tessandra; Sui, Yu-Ting; Gonzalez-Cuyar, Luis F et al. (2014) Cheek cell-derived *-synuclein and DJ-1 do not differentiate Parkinson's disease from control. Neurobiol Aging 35:418-20

Showing the most recent 10 out of 81 publications