The Cognitive and Behavioral Core will provide psychometric assessments of neuropsychological functions for all projects. In addition, this Core will provide complementary support in the following two synergistic domains: (1) design, analysis, and development of novel cognitive neuropsychological tasks that will be used to assess the functionality ofthe fronto-striatal circuits impacted by Parkinson's disease (PD) and its treatment, and (2) neurocomputational and mathematical models of the fronto-striatal circuits for feedbackdriven reinforcement learning and neuro-economic decision making. These models will inform the development of new behavioral tasks and will provide behavioral measures to inform the analysis of the brain imaging data collected from these tasks.

Public Health Relevance

The interdisciplinary integration of these cognitive and behavioral neuroscience methods into the proposed brain imaging and clinical aims is part of what will make this Center uniquely capable of furthering our understanding ofthe neural systems mediating higher cognitive functioning in PD patients.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Specialized Center (P50)
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Special Emphasis Panel (ZNS1-SRB-E)
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Feinstein Institute for Medical Research
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Ko, Ji Hyun; Lerner, Renata P; Eidelberg, David (2015) Effects of levodopa on regional cerebral metabolism and blood flow. Mov Disord 30:54-63
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