The Imaging Core will provide essential support for the PET studies (Projects 1-3) and the MR studies (Project 2) proposed in this application. In these studies, multiple radiotracers will be administered intravenously to all research participants in conjunction with PET imaging. In Project 1, Parkinson's disease (PD) patients and healthy volunteer subjects will be scanned with [ [18] F]-FDG PET (to measure glucose metabolism), [[15] 0]-H20 PET (to visualize cerebral blood flow) and [ [82]Rb] PET (to assess blood brain barrier (BBB) permeability). In Project 2, PD patients will be scanned with [18] F-FDG (for glucose metabolism), [[11] C]-PIB (to detect protein aggregation), and [[18] F]-FPCIT (to trace striatal dopamine transporter binding). In Project 3, subjects will also undergo FPCIT PET imaging.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS071675-04
Application #
8549329
Study Section
Special Emphasis Panel (ZNS1-SRB-E)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
4
Fiscal Year
2013
Total Cost
$132,978
Indirect Cost
$52,870
Name
Feinstein Institute for Medical Research
Department
Type
DUNS #
110565913
City
Manhasset
State
NY
Country
United States
Zip Code
11030
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