The primary objecfive of the Clinical Resource Core (CRC) is to provide comprehensive programs for recruitment, community outreach and educafion, core clinical assessments, and genotyping and biological sample storage for all projects of the Udall Center. The CRC will also serve a coordinafion role between projects and cores to assure that all subjects participating in the projects of our Udall Center will complete a minimal multidisciplinary dataset, including the following: clinical rafings (off-state UPDRS), a standardized neuropsychological testing battery (see Cognitive and Behavioral core), off-state FDG PET, off-state, routine anatomical MRI, DNA banking (see below), and brain donation and banking when applicable. Data collected through the CRC will be shared with other Udail Centers and PD invesfigators at other institutions through the PD-DOC registry (see Stafisfics and Data Management Core).

Public Health Relevance

This core will serve a critical funcfion in the proposed Udall Center by coordinating all aspects of subject recruitment, clinical assessments, as well as providing support for several of the anticipated investigational procedures.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Specialized Center (P50)
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Special Emphasis Panel (ZNS1-SRB-E)
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Feinstein Institute for Medical Research
United States
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Ko, Ji Hyun; Lerner, Renata P; Eidelberg, David (2015) Effects of levodopa on regional cerebral metabolism and blood flow. Mov Disord 30:54-63
Peng, Shichun; Ma, Yilong; Spetsieris, Phoebe G et al. (2014) Characterization of disease-related covariance topographies with SSMPCA toolbox: effects of spatial normalization and PET scanners. Hum Brain Mapp 35:1801-14
Peng, Shichun; Eidelberg, David; Ma, Yilong (2014) Brain network markers of abnormal cerebral glucose metabolism and blood flow in Parkinson's disease. Neurosci Bull 30:823-37
Ko, Ji Hyun; Feigin, Andrew; Mattis, Paul J et al. (2014) Network modulation following sham surgery in Parkinson's disease. J Clin Invest 124:3656-66
Holtbernd, Florian; Gagnon, Jean-Fran├žois; Postuma, Ron B et al. (2014) Abnormal metabolic network activity in REM sleep behavior disorder. Neurology 82:620-7
Tomer, Rachel; Slagter, Heleen A; Christian, Bradley T et al. (2014) Love to win or hate to Lose? Asymmetry of dopamine D2 receptor binding predicts sensitivity to reward versus punishment. J Cogn Neurosci 26:1039-48
Ko, Ji Hyun; Spetsieris, Phoebe; Ma, Yilong et al. (2014) Quantifying significance of topographical similarities of disease-related brain metabolic patterns. PLoS One 9:e88119
Holtbernd, Florian; Eidelberg, David (2014) The utility of neuroimaging in the differential diagnosis of parkinsonian syndromes. Semin Neurol 34:202-9
Papay, Kimberly; Xie, Sharon X; Stern, Matthew et al. (2014) Naltrexone for impulse control disorders in Parkinson disease: a placebo-controlled study. Neurology 83:826-33
Spetsieris, Phoebe; Ma, Yilong; Peng, Shichun et al. (2013) Identification of disease-related spatial covariance patterns using neuroimaging data. J Vis Exp :

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