The Udall Center for Excellence in Parkinson Disease Research at the Mayo Clinic is an integrated, multi-disciplinary research program focusing on of the """"""""Genetics and Molecular Biology of Parkinsonism."""""""" The Udall Center draws upon the clinical strengths of the Mayo Clinic Movement Disorder Section with its longitudinal studies of Parkinson disease (PD) and a focus on the clinical genetics of familial Parkinsonism, a large brain bank of Parkinsonian disorders and strong institutional commitment to PD research and education. All components of the Udall Center are based in Jacksonville, Florida, although core resources in Rochester, Minnesota, particularly the Division of Biomedical Statistics will be used. Mayo Foundation educational resources, including sponsored seminar series and graduate level educational courses on PD and other neurodegenerative disorders are also utilized. The proposal is highly innovative and original in that it addresses the intriguing interaction between two molecules with surprising similarities, tau and a-synuclein, both of which are strongly implicated as critical factors in pathogenesis of parkinsonian disorders. The clinical, genetic and pathologic studies proposed capitalize on inherent strengths of the Udall Center investigators and unique clinical, genetic and pathological resources that have been built over the years due to the fervent devotion of investigators to better understanding PD and related disorders. The Center also brings established investigators in complementary areas of research (Drs. Rademakers and Petrucelli) to the task of understanding how tau is related PD and how tau-directed therapies may translate into novel treatments for PD and parkinsonian tauopathies. The proposed Center will have three projects and four cores with an overarching theme to understand the role of tau in PD and parkinsonian tauopathies. Project 1, entitled """"""""Identification of novel parkinsonian genes by whole-genome sequencing,"""""""" is led by Rosa Rademakers, PhD. Project 2, entitled """"""""Genetic determinants of a-synuclein and tau pathology in Parkinsonism,"""""""" is led by Dennis W. Dickson, MD. Project 3, entitled """"""""Identification and testing of novel compounds to treat Parkinsonism,"""""""" is led by Leonard Petrucelli, PhD. Core A (Administration) and Core D (Neuropathology) are led by Dennis W. Dickson, MD. Core B (Clinical) is led by Zbigniew K. Wszoiek, MD. Core C (Genetics) is led by Owen A. Ross, PhD.
Parkinson disease (PD) is one of the leading causes of neurologic disability. Increasingly, it is recognized that there is a genetic component to risk for PD and related disorders sometimes referred to as Parkinsonism-plus. Research in our Center will find new genes for familial PD and increase our understanding of how common differences in the genetic make-up of individuals leads to sporadic PD. Finally, our research will work towards discovering drugs that can treat PD and Parkinsonism-plus disorders.
|Konno, T; Yoshida, K; Mizuno, T et al. (2017) Clinical and genetic characterization of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia associated with CSF1R mutation. Eur J Neurol 24:37-45|
|Wang, Lisa; Heckman, Michael G; Aasly, Jan O et al. (2017) Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study. Neurobiol Aging 49:217.e1-217.e4|
|Koga, Shunsuke; Parks, Adam; Uitti, Ryan J et al. (2017) Profile of cognitive impairment and underlying pathology in multiple system atrophy. Mov Disord 32:405-413|
|Ando, Maya; Fiesel, Fabienne C; Hudec, Roman et al. (2017) The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity. Mol Neurodegener 12:32|
|Heckman, Michael G; Kasanuki, Koji; Diehl, Nancy N et al. (2017) Parkinson's disease susceptibility variants and severity of Lewy body pathology. Parkinsonism Relat Disord 44:79-84|
|Sanchez-Contreras, Monica; Heckman, Michael G; Tacik, Pawel et al. (2017) Study of LRRK2 variation in tauopathy: Progressive supranuclear palsy and corticobasal degeneration. Mov Disord 32:115-123|
|(2017) 19th Workshop of the International Stroke Genetics Consortium, April 28-29, 2016, Boston, Massachusetts, USA: 2016.001 MRI-defined cerebrovascular genomics-The CHARGE consortium. Neurol Genet 3:S2-S11|
|Mackenzie, Ian R; Nicholson, Alexandra M; Sarkar, Mohona et al. (2017) TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. Neuron 95:808-816.e9|
|Sitek, Emilia J; Naro?a?ska, Ewa; Konieczna, Seweryna et al. (2017) Drawing analysis in the assessment of patients with neurodegenerative diseases. Neurology 88:218-219|
|Tipton, Philip W; Guthrie, Kimberly; Strongosky, Audrey et al. (2017) Spinocerebellar ataxia 15: A phenotypic review and expansion. Neurol Neurochir Pol 51:86-91|
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