The Biostatistics Core will provide high quality, efficient, integrated collaboration in and support of the proposed Center on Deep Brain Stimulation (DBS) for Parkinson's Disease (PD). The overall theme of the Center is to develop novel, circuit based deep brain stimulation (DBS) therapies for Parkinson's disease (PD). As a foundation for all three proposed projects in support of this theme, this Core will provide: personnel with the appropriate breadth and depth of expertise; services in study design, study logistics planning and implementation, data management and quality control, and statistical analysis; data integration with and transfer to the NIH/NINDS Parkinson's Disease Biomarker Program Data Management Resource; career development related to statistical concepts for clinical and basic scientists in the Center; participation in outreach and dissemination activities; and other resources as needed. We will interact closely and extensively with the Administrative Core, the Clinical Core, and the Imaging Core on scientific and management services for each project as it is carried out; on the seamless integration of all cores' services with each other to best support the projects; on the prioritization of this Core's work across the needs of the projects; on the ongoing career development of Center investigators; and on supporting future research and funding opportunities on DBS strategies in PD which are motivated by this proposed Center. This Core's personnel will participate with project teams before study initiation, during study execution, through study dissemination, and as part of novel cross-project initiatives that will integrate the projects to provide innovative insight into the pathophysiological basis of motor signs in PD. This Core's continuity of involvement will provide a common connection among the projects and continuous interaction with the other cores, spanning the entire proposed period. Lastly, we will provide resources for additional exploratory analyses that come to light as the research progresses, taking full advantage of the Center's careful data collection and management, thereby also facilitating the development of innovative hypotheses for future research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
1P50NS098573-01
Application #
9194006
Study Section
Special Emphasis Panel (ZNS1-SRB-J (12))
Project Start
Project End
Budget Start
2016-09-15
Budget End
2017-05-31
Support Year
1
Fiscal Year
2016
Total Cost
$104,298
Indirect Cost
$35,681
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Milham, Michael P; Ai, Lei; Koo, Bonhwang et al. (2018) An Open Resource for Non-human Primate Imaging. Neuron 100:61-74.e2
Patriat, Rémi; Cooper, Scott E; Duchin, Yuval et al. (2018) Individualized tractography-based parcellation of the globus pallidus pars interna using 7T MRI in movement disorder patients prior to DBS surgery. Neuroimage 178:198-209
Peña, Edgar; Zhang, Simeng; Patriat, Remi et al. (2018) Multi-objective particle swarm optimization for postoperative deep brain stimulation targeting of subthalamic nucleus pathways. J Neural Eng 15:066020
Zhang, Simeng; Connolly, Allison T; Madden, Lauren R et al. (2018) High-resolution local field potentials measured with deep brain stimulation arrays. J Neural Eng 15:046019
Plantinga, Birgit R; Temel, Yasin; Duchin, Yuval et al. (2018) Individualized parcellation of the subthalamic nucleus in patients with Parkinson's disease with 7T MRI. Neuroimage 168:403-411
Slopsema, Julia P; Peña, Edgar; Patriat, Remi et al. (2018) Clinical deep brain stimulation strategies for orientation-selective pathway activation. J Neural Eng 15:056029
Amundsen Huffmaster, Sommer L; Van Acker 3rd, Gustaf M; Luchies, Carl W et al. (2018) Muscle Synergies Obtained from Comprehensive Mapping of the Cortical Forelimb Representation Using Stimulus Triggered Averaging of EMG Activity. J Neurosci 38:8759-8771
Duchin, Yuval; Shamir, Reuben R; Patriat, Remi et al. (2018) Patient-specific anatomical model for deep brain stimulation based on 7 Tesla MRI. PLoS One 13:e0201469
Lehto, Lauri J; Slopsema, Julia P; Johnson, Matthew D et al. (2017) Orientation selective deep brain stimulation. J Neural Eng 14:016016
Tuite, Paul (2017) Brain Magnetic Resonance Imaging (MRI) as a Potential Biomarker for Parkinson's Disease (PD). Brain Sci 7:

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