This grant requests 5 years of funding support for continuing operation of the Washington National Primate Research Center at the University of Washington (WaNPRC). The goal of this proposal is to support a broad-based research resources program, providing biomedical scientists the opportunity to conduct research using nonhuman primate (NHP) models for human health-related and NHP biologic issues. This goal will be attained through support for scientific intellectual resources, administration, animal support resources, facilities, and operations. Support is requested for translational and pre-clinical resource support in AIDS-related research, Neuroscience, NHP Systems Biology, Developmental and Reproductive Biology, and Global Programs (Research Cores). New research initiatives will develop novel NHP models and expand related research resources, including additional core scientists. Support for research resource related studies is requested to provide innovative research directions and better characterization of the NHP model. The WaNPRC will focus on efficient access to Center resources, with particular emphasis placed on support for affiliate research activities. This proposal also includes support for a broad program of animal care and technical support for breeding, housing, and research activities (Primate Resources Division), including both domestic and international sites of operation. Administrative support is requested to ensure appropriate management of Center finances and operations, focusing on improved efficiency and effective support for research activities. Support is requested for WaNPRC breeding colonies located in Seattle, WA and at our locations in New Iberia, LA and Alice, TX. All primates in WaNPRC facilities are housed and cared for under conditions that meet or exceed NIH standards per the Guide for the Care and Use of Laboratory Animals, ILAR recommendations, and the AAALAC accreditation standards for NHPs. All lentivirus-infected primates are housed in ABSL2/3 containment facilities with appropriate biosafety procedures. The University of Washington, including the WaNPRC, is fully accredited by AAALAC International.
; The Washington National Primate Research Center provides the necessary non-human primate disease models for a variety of diseases and conditions that affect humans such as HIV/AIDS, influenza, Parkinson's disease, and neonatal asphyxia. The availability of these models allows for the development of preventive and interventive medicine and medical techniques to improve public health.
|Hogan, Michael J; Conde-Motter, Angela; Jordan, Andrea P O et al. (2018) Increased surface expression of HIV-1 envelope is associated with improved antibody response in vaccinia prime/protein boost immunization. Virology 514:106-117|
|Patton, Dorothy L; Sweeney, Yvonne C; Baldessari, Audrey E et al. (2018) The Chlamydia trachomatis Plasmid and CT135 Virulence Factors Are Not Essential for Genital Tract Infection or Pathology in Female Pig-Tailed Macaques. Infect Immun 86:|
|Hensley-McBain, Tiffany; Berard, Alicia R; Manuzak, Jennifer A et al. (2018) Intestinal damage precedes mucosal immune dysfunction in SIV infection. Mucosal Immunol 11:1429-1440|
|Meister, Miriam L R; Buffalo, Elizabeth A (2018) Neurons in primate entorhinal cortex represent gaze position in multiple spatial reference frames. J Neurosci :|
|Adams Waldorf, Kristina M; Nelson, Branden R; Stencel-Baerenwald, Jennifer E et al. (2018) Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain. Nat Med 24:368-374|
|Mitchell, Timothy; MacDonald, James W; Srinouanpranchanh, Sengkeo et al. (2018) Evidence of cardiac involvement in the fetal inflammatory response syndrome: disruption of gene networks programming cardiac development in nonhuman primates. Am J Obstet Gynecol 218:438.e1-438.e16|
|Choi, Hannah; Pasupathy, Anitha; Shea-Brown, Eric (2018) Predictive Coding in Area V4: Dynamic Shape Discrimination under Partial Occlusion. Neural Comput 30:1209-1257|
|Cole, Amy L; Cosgrove Sweeney, Yvonne; Lasseter, Amanda G et al. (2018) Evaluation of the Pig-Tailed Macaque (Macaca nemestrina) as a Model of Human Staphylococcus aureus Nasal Carriage. Infect Immun 86:|
|Kraft, John C; Treuting, Piper M; Ho, Rodney J Y (2018) Indocyanine green nanoparticles undergo selective lymphatic uptake, distribution and retention and enable detailed mapping of lymph vessels, nodes and abnormalities. J Drug Target 26:494-504|
|Gulinello, Maria; Mitchell, Heather A; Chang, Qiang et al. (2018) Rigor and reproducibility in rodent behavioral research. Neurobiol Learn Mem :|
Showing the most recent 10 out of 261 publications