The 5-year renewal for Grant P51 RR00163-50 requests funding for programs at the ONPRC that support biomedical research. The application reflects a new strategic focus on interdisciplinary research to optimize the use and development of nonhuman primate (NHP) models.
The aims of this application are to: 1) provide the infrastructure support necessary to conduct advanced biomedical research for which NHPs are used to accelerate progress in understanding human diseases;2) enhance the Center's resources (scientific expertise, laboratories, animal services, research support cores and equipment) so as to serve as a regional and national resource;3) increase the availability of defined NHPs for biomedical research through support of our programs to expand the SPF Indian-origin rhesus macaque breeding program;and 4) expand research programs utilizing NHPs in stem cell biology, aging, obesity, genetics, infectious diseases, vaccine development, neuroscience and women's health. To accomplish these aims, support is requested in three broad areas. First, Administration &Center Operations provide the administrative and service support required for all aspects of the ONPRC. Units include: 1) the Director's Office;2) Administrative Services (Business Services, Environmental Health &Radiation Safety, Facilities &Property, Information Technology &Engineering, and the Research Library);3) Animal Resources (Administration, Operations, Behavioral Services, Pathology Services, Surgery Services, and Clinical Medicine);and 4) Research Support Cores (Assisted Reproductive Technology, Endocrine Technology, Imaging &Morphology, Immunology, Magnetic Resonance Imaging, Molecular &Cellular Biology, and Virology &Serology). Secondy, Scientific Components include support for: 1) Scientific Divisions (Neuroscience, Pathobiology &Immunology, and Reproductive Sciences) and their interdisciplinary Working Groups (Biology of Aging, Metabolic Disease, and Stem Cell &Developmental Biology);2) the Collaborative Research Unit that facilitates externallyfunded research;3) the Pilot Project Program;and 4) Resource-Related Research. Finally, Improvement & Modernization includes funds for equipment and alterations and renovations.
The funds requested will provide support for the research infrastructure required to conduct the most advanced biomedical research using NHPs as models of human health and disease, and to meet the needs of new emerging areas of research in which the NHP model is critical, including increased biodefense and HIV vaccine research, as well as translational research initiatives that are highly interdisciplinary in nature.
|Ma, Hong; Marti Gutierrez, Nuria; Morey, Robert et al. (2016) Incompatibility between Nuclear and Mitochondrial Genomes Contributes to an Interspecies Reproductive Barrier. Cell Metab 24:283-94|
|Bimber, Benjamin N; Raboin, Michael J; Letaw, John et al. (2016) Whole-genome characterization in pedigreed non-human primates using genotyping-by-sequencing (GBS) and imputation. BMC Genomics 17:676|
|Burton, Katherine J; Li, Xiaohan; Li, Baoan et al. (2016) Expression of prokineticin 2 and its receptor in the macaque monkey brain. Chronobiol Int 33:191-9|
|McCurdy, Carrie E; Schenk, Simon; Hetrick, Byron et al. (2016) Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. JCI Insight 1:e86612|
|Eckalbar, Walter L; Schlebusch, Stephen A; Mason, Mandy K et al. (2016) Transcriptomic and epigenomic characterization of the developing bat wing. Nat Genet 48:528-36|
|Kohama, Steven G; Renner, Lauren; Landauer, Noelle et al. (2016) Effect of Ovarian Hormone Therapy on Cognition in the Aged Female Rhesus Macaque. J Neurosci 36:10416-10424|
|Colgin, L M A; Schwahn, D J; Castillo-Alcala, F et al. (2016) Pheochromocytoma in Old World Primates (Macaca mulatta and Chlorocebus aethiops). Vet Pathol 53:1259-1263|
|Dufour, Brett D; McBride, Jodi L (2016) Intravascular AAV9 Administration for Delivering RNA Silencing Constructs to the CNS and Periphery. Methods Mol Biol 1364:261-75|
|Winthrop, Kevin; Rivera, Andrea; Engelmann, Flora et al. (2016) A Rhesus Macaque Model of Pulmonary Nontuberculous Mycobacterial Disease. Am J Respir Cell Mol Biol 54:170-6|
|Hammarlund, Erika; Thomas, Archana; Poore, Elizabeth A et al. (2016) Durability of Vaccine-Induced Immunity Against Tetanus and Diphtheria Toxins: A Cross-sectional Analysis. Clin Infect Dis 62:1111-8|
Showing the most recent 10 out of 325 publications