Abstract

The California National Primate Research Center (CNPRC) Is one of eight National Primate Research Centers (NPRCs) funded by the National Institutes of Health, National Center for Research Resource. This renewal application seeksisupport for Administrative Services, Primate Services, Core Science Services, Research Units and Modernization and Improvement. To enhance the CNPRC's ability to serve as a regional, national, and international resource and provide the infrastructure support essential to conduct successful research on nonhuman primates, we are proposing the following specific aims. 1) Advance translational research through the development of nonhuman primate models; 2) Foster an environment that encourages and emphasizes the scientific expertise that is critical to carry out the mission of the NPRC Program and the CNPRC; 3) Encourage partnerships to maximize the research investment; 4) Enhance the research infrastructure; 5) Strengthen the research workforce; 6) Increase efficiencies in the use of CNPRC resources.

Public Health Relevance

The CNPRC will expand collaborations to enhance translational research through the development of new nonhuman primate models of disease by utilizing basic knowledge and technologies of Staff Scientists and scientists outside of the CNPRC.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Primate Research Center Grants (P51)
Project #
3P51OD011107-53S2
Application #
8899678
Study Section
Special Emphasis Panel (ZRR1-CM-5 (01))
Program Officer
Harding, John D
Project Start
1997-05-01
Project End
2015-04-30
Budget Start
2014-08-21
Budget End
2015-04-30
Support Year
53
Fiscal Year
2014
Total Cost
$499,950
Indirect Cost

  Institution

Name
University of California Davis
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Dudley, Dawn M; Van Rompay, Koen K; Coffey, Lark L et al. (2018) Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. Nat Med 24:1104-1107
Rosenzweig, Ephron S; Brock, John H; Lu, Paul et al. (2018) Restorative effects of human neural stem cell grafts on the primate spinal cord. Nat Med 24:484-490
Coffey, Lark L; Keesler, Rebekah I; Pesavento, Patricia A et al. (2018) Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease. Nat Commun 9:2414
Weir, R K; Bauman, M D; Jacobs, B et al. (2018) Protracted dendritic growth in the typically developing human amygdala and increased spine density in young ASD brains. J Comp Neurol 526:262-274
Guoynes, C D; Simmons, T C; Downing, G M et al. (2018) Chronic Intranasal Oxytocin has Dose-dependent Effects on Central Oxytocin and Vasopressin Systems in Prairie Voles (Microtus ochrogaster). Neuroscience 369:292-302
Keeffe, Jennifer R; Van Rompay, Koen K A; Olsen, Priscilla C et al. (2018) A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates. Cell Rep 25:1385-1394.e7
Presicce, Pietro; Park, Chan-Wook; Senthamaraikannan, Paranthaman et al. (2018) IL-1 signaling mediates intrauterine inflammation and chorio-decidua neutrophil recruitment and activation. JCI Insight 3:
Freeman, Sara M; Rebout, Nancy; Bales, Karen L (2018) Effect of reward type on object discrimination learning in socially monogamous coppery titi monkeys (Callicebus cupreus). Am J Primatol 80:e22868
Hopkins, Laurie E; Laing, Emilia A; Peake, Janice L et al. (2018) Repeated Iron-Soot Exposure and Nose-to-brain Transport of Inhaled Ultrafine Particles. Toxicol Pathol 46:75-84
Parker, Karen J; Garner, Joseph P; Oztan, Ozge et al. (2018) Arginine vasopressin in cerebrospinal fluid is a marker of sociality in nonhuman primates. Sci Transl Med 10:

Showing the most recent 10 out of 421 publications