The objective of this proposal is to continue support of the infrastructure of the Southwest National Primate Research Center (SNPRC). The SNPRC is located on the campus of the Southwest Foundation for Biomedical Research, its host institution. The SNPRC maintains over 4,000 nonhuman primates, primarily baboons, macaques, marmosets, and chimpanzees. It maintains large breeding populations of baboons, rhesus macaques, and common marmosets. During the current grant period, the SNPRC provided resources to 290 investigators from 35 states. The base grant is composed of four types of components: Administration, Primate Resources, Veterinary Resources, and Research Resources. The Research Resource components and the research programs that utilize them are divided among four Focus Groups: Infectious Diseases and Biodefense, Chronic Diseases, Development and Aging, and Genomics. The mission of the SNPRC is """"""""To improve the health of our global community through innovative biomedical research with nonhuman primates."""""""" Consistent with this mission, the SNPRC is committed to translational research and is a partner in two CTSA applications that are in review. The administration, primate resource, veterinary resource, and research resource infrastructures supported by the base grant enable the SNPRC to be responsive to national biomedical research needs and to accommodate investigators who want to access Center resources for collaborative research purposes. Special, and in some cases unique, strengths of the SNPRC are a wide variety of primate species to meet diverse research needs;the largest pedigreed and genotyped population of nonhuman primates available for genetic research;broad research opportunities with the largest chimpanzee population at any National Primate Research Center;ABSL-3 and ABSL-4 facilities;research emphasis and expertise on gene discovery for common chronic diseases, development of vaccines and drugs for infectious diseases, preventions and treatments of neonatal diseases, and stem cell biology;and service as a national resource for genetic management of nonhuman primates.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Primate Research Center Grants (P51)
Project #
5P51OD011133-15
Application #
8478225
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Program Officer
Harding, John D
Project Start
1999-06-06
Project End
2014-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
15
Fiscal Year
2013
Total Cost
$7,069,521
Indirect Cost
$3,022,632
Name
Texas Biomedical Research Institute
Department
Type
DUNS #
007936834
City
San Antonio
State
TX
Country
United States
Zip Code
78245
Li, Li; Barry, Vivian; Daffis, Stephane et al. (2018) Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells. J Hepatol 68:912-921
Alfson, Kendra J; Avena, Laura E; Delgado, Jenny et al. (2018) A Single Amino Acid Change in the Marburg Virus Glycoprotein Arises during Serial Cell Culture Passages and Attenuates the Virus in a Macaque Model of Disease. mSphere 3:
Confer, Alexandra; Owston, Michael A; Kumar, Shyamesh et al. (2018) Multiple endocrine neoplasia-like syndrome in 24 baboons (Papio spp.). J Med Primatol 47:434-439
Obregon-Perko, Veronica; Hodara, Vida L; Parodi, Laura M et al. (2018) Baboon CD8 T cells suppress SIVmac infection in CD4 T cells through contact-dependent production of MIP-1?, MIP-1?, and RANTES. Cytokine 111:408-419
Seferovic, Maxim; Sánchez-San Martín, Claudia; Tardif, Suzette D et al. (2018) Experimental Zika Virus Infection in the Pregnant Common Marmoset Induces Spontaneous Fetal Loss and Neurodevelopmental Abnormalities. Sci Rep 8:6851
Galeano, Carlos; Qiu, Zhifang; Mishra, Anuja et al. (2018) The Route by Which Intranasally Delivered Stem Cells Enter the Central Nervous System. Cell Transplant 27:501-514
Mustonen, Allison; Gonzalez, Olga; Mendoza, Elda et al. (2018) Uremic encephalopathy in a rhesus macaque (Macaca mulatta): A case report and a brief review of the veterinary literature. J Med Primatol :
Yang, Guang; Hong, Hyenjong; Torres, April et al. (2018) Standards for Deriving Nonhuman Primate-Induced Pluripotent Stem Cells, Neural Stem Cells and Dopaminergic Lineage. Int J Mol Sci 19:
Kuo, A H; Li, J; Li, C et al. (2018) Poor perinatal growth impairs baboon aortic windkessel function. J Dev Orig Health Dis 9:137-142
Kuo, Anderson H; Li, Cun; Mattern, Vicki et al. (2018) Sex-dimorphic acceleration of pericardial, subcutaneous, and plasma lipid increase in offspring of poorly nourished baboons. Int J Obes (Lond) 42:1092-1096

Showing the most recent 10 out of 294 publications