The objective of this proposal is to continue support of the infrastructure of the Southwest National Primate Research Center (SNPRC). The SNPRC is located on the campus of the Texas Biomedical Research Institute, its host institution. The SNPRC maintains approximately 2,500 nonhuman primates, primarily baboons, macaques, marmosets, and chimpanzees. It maintains breeding populations of baboons, rhesus macaques, and common marmosets. The base grant is composed of Administration components;SNPRC Service components which includes the various veterinary, research, and behavioral service units of the SNPRC;Animal Colony components for the baboons, macaques, marmosets, and chimpanzees;the Immunology Core Laboratory;and two Resource Related Research Projects, one on Genomics and one on Metabolic Disease Profiling. The research programs in the Center are based in one of three Research Facilitation Groups. These groups provide expertise and support to investigators conducting research in the Center. The groups are Infectious Disease and Biodefense;Metabolic Diseases and Genomics;and Physiology, Behavior and Basic Medicine. The mission of the SNPRC is to improve the health of our global community through innovative biomedical research with nonhuman primates. Consistent with this mission, the SNPRC is committed to translational research. The administration, primate resources, veterinary resources, and research resource infrastructures supported by the base grant enable the SNPRC to be responsive to national biomedical research needs and to accommodate investigators who want to access Center resources for collaborative research purposes. Special, and in some cases unique, strengths of the SNPRC are a wide variety of primate species to meet diverse research needs;the largest pedigreed and genotyped population of nonhuman primates available for genetic research;research opportunities with chimpanzees;ABSL-3 and ABSL-4 facilities;and research emphasis and expertise on gene discovery for common chronic diseases, development of vaccines, drugs for infectious disease, and stem cell biology.

Public Health Relevance

The Southwest National Primate Research Center (SNPRC) facilitates innovative biomedical research that advances human health through provision of nonhuman primate-related resources to investigators from around the country. The SNPRC maintains colonies of baboons, macaques, marmosets, and chimpanzees for support of biomedical research projects. The Center also has internal research efforts focused on genomics, metabolic disease, infectious disease, and behavior.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Primate Research Center Grants (P51)
Project #
2P51OD011133-16
Application #
8667548
Study Section
Special Emphasis Panel (ZOD1)
Program Officer
Harding, John D
Project Start
1999-06-06
Project End
2016-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
16
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Texas Biomedical Research Institute
Department
Type
DUNS #
City
San Antonio
State
TX
Country
United States
Zip Code
78245
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Manickam, Cordelia; Rajakumar, Premeela; Wachtman, Lynn et al. (2016) Acute Liver Damage Associated with Innate Immune Activation in a Small Nonhuman Primate Model of Hepacivirus Infection. J Virol 90:9153-62
Schlabritz-Loutsevitch, Natalia; Gygax, Scott E; Dick Jr, Edward et al. (2016) Vaginal Dysbiosis from an Evolutionary Perspective. Sci Rep 6:26817
Jensen, Jeffrey T; Hanna, Carol; Yao, Shan et al. (2016) Transcervical administration of polidocanol foam prevents pregnancy in female baboons. Contraception 94:527-533
Lutz, Corrine K; Coleman, Kris; Worlein, Julie M et al. (2016) Factors influencing alopecia and hair cortisol in rhesus macaques (Macaca mulatta). J Med Primatol 45:180-8

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