This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. High rates of human fertility are endemic in many of the poorest areas on earth. Reversible methods are impractical for a variety of reasons. Therefore, safe and low cost non-surgical methods of female and male sterilization are urgently needed. This project will use the macaque model to explore a novel approach for non-surgical female sterilization. The purpose of this project is to explore the hypotheses that Polidocanol foam delivered transcervically will selectively damage the fallopian tube epithelium and result in tubal blockage without injury to non-target tissues such as the uterine cavity or intra abdominal organs.
The Specific Aims are to: (1) develop a reproducible technique to cannulate the macaque cervix and assess tubal patency in vivo;(2) determine if Polidocanol foam administered transcervically will result in tubal blockade observed in vivo;and 3) describe the gross and microscopic tissue effects of Polidocanol foam on the reproductive tract and non-target tissues.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Primate Research Center Grants (P51)
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Special Emphasis Panel (ZRR1-CM-8 (01))
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Oregon Health and Science University
Schools of Medicine
United States
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Meyer, Thomas J; Held, Ulrike; Nevonen, Kimberly A et al. (2016) The Flow of the Gibbon LAVA Element Is Facilitated by the LINE-1 Retrotransposition Machinery. Genome Biol Evol 8:3209-3225
Chadderdon, S M; Belcik, J T; Bader, L et al. (2016) Vasoconstrictor eicosanoids and impaired microvascular function in inactive and insulin-resistant primates. Int J Obes (Lond) 40:1600-1603
Dufour, Brett D; McBride, Jodi L (2016) Intravascular AAV9 Administration for Delivering RNA Silencing Constructs to the CNS and Periphery. Methods Mol Biol 1364:261-75
Slayden, Ov Daniel (2016) Translational In Vivo Models for Women's Health: The Nonhuman Primate Endometrium--A Predictive Model for Assessing Steroid Receptor Modulators. Handb Exp Pharmacol 232:191-202
Pleil, Kristen E; Helms, Christa M; Sobus, Jon R et al. (2016) Effects of chronic alcohol consumption on neuronal function in the non-human primate BNST. Addict Biol 21:1151-1167
Barr, Tasha; Girke, Thomas; Sureshchandra, Suhas et al. (2016) Alcohol Consumption Modulates Host Defense in Rhesus Macaques by Altering Gene Expression in Circulating Leukocytes. J Immunol 196:182-95
Xu, Jing; McGee, Whitney K; Bishop, Cecily V et al. (2015) Exposure of female macaques to Western-style diet with or without chronic T in vivo alters secondary follicle function during encapsulated 3-dimensional culture. Endocrinology 156:1133-42
Sullivan, Elinor L; Riper, Kellie M; Lockard, Rachel et al. (2015) Maternal high-fat diet programming of the neuroendocrine system and behavior. Horm Behav 76:153-61
Jensen, Jeffrey T; Hanna, Carol; Yao, Shan et al. (2015) Characterization of tubal occlusion after transcervical polidocanol foam (PF) infusion in baboons. Contraception 92:96-102
Halliley, Jessica L; Tipton, Christopher M; Liesveld, Jane et al. (2015) Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow. Immunity 43:132-45

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