This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. INTRODUCTION: Concerns regarding alopecia in nonhuman primates are justified given that hair performs many essential functions. METHODS: The occurrence of alopecia is often attributed to the level of psychological wellbeing, and behavioral causes have become a routine, unconfirmed default diagnosis for alopecia in captive nonhuman primates. However, before attributing alopecia to abnormal behavior, it is necessary to rule out medical causes of alopecia. In this study, a medical and behavioral assessment of animals with and without alopecia was performed with the aim of designing a guide to approaching cases of nonhuman primate alopecia. The well-established algorithm for evaluation of alopecia in companion animal species was used as the basis for the medical evaluation. In addition, a behavioral evaluation was used to assess animals for the presence or absence of hair plucking. The hypothesis tested was that the commonly used diagnostic evaluation for alopecia in companion animal species is not applicable to nonhuman primates. RESULTS/DISCUSSION: Aside from the histopathology and behavioral assessment differences, few clinically relevant significant differences were found between animals with alopecia and control animals. As a result, the hypothesis was confirmed and we determined that application of the diagnostic plan for alopecia that is used in companion animal species to nonhuman primates is a practice that needs to be reexamined.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Primate Research Center Grants (P51)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Tulane University
Obstetrics & Gynecology
Schools of Medicine
New Orleans
United States
Zip Code
Scholl, Dorothy C; Embers, Monica E; Caskey, John R et al. (2016) Immunomodulatory effects of tick saliva on dermal cells exposed to Borrelia burgdorferi, the agent of Lyme disease. Parasit Vectors 9:394
Robillard, Katelyn N; Lee, Kim M; Chiu, Kevin B et al. (2016) Glial cell morphological and density changes through the lifespan of rhesus macaques. Brain Behav Immun 55:60-9
Lee, Kim M; Chiu, Kevin B; Sansing, Hope A et al. (2016) The flavivirus dengue induces hypertrophy of white matter astrocytes. J Neurovirol 22:831-839
Stentiford, G D; Becnel, J J; Weiss, L M et al. (2016) Microsporidia - Emergent Pathogens in the Global Food Chain. Trends Parasitol 32:336-48
Calenda, Giulia; Villegas, Guillermo; Barnable, Patrick et al. (2016) MZC gel inhibits SHIV-RT and HSV-2 in macaque vaginal mucosa and SHIV-RT in rectal mucosa. J Acquir Immune Defic Syndr :
Simon, Liz; Song, Keijing; Vande Stouwe, Curtis et al. (2016) Δ9-Tetrahydrocannabinol (Δ9-THC) Promotes Neuroimmune-Modulatory MicroRNA Profile in Striatum of Simian Immunodeficiency Virus (SIV)-Infected Macaques. J Neuroimmune Pharmacol 11:192-213
Inglis, Fiona M; Lee, Kim M; Chiu, Kevin B et al. (2016) Neuropathogenesis of Chikungunya infection: astrogliosis and innate immune activation. J Neurovirol 22:140-8
Kumar, Vinay; Torben, Workineh; Kenway, Carys S et al. (2016) Longitudinal Examination of the Intestinal Lamina Propria Cellular Compartment of Simian Immunodeficiency Virus-Infected Rhesus Macaques Provides Broader and Deeper Insights into the Link between Aberrant MicroRNA Expression and Persistent Immune Activati J Virol 90:5003-19
Song, Ruijiang; Pace, Craig; Seaman, Michael S et al. (2016) Distinct HIV-1 Neutralization Potency Profiles of Ibalizumab-Based Bispecific Antibodies. J Acquir Immune Defic Syndr 73:365-373
Liu, David X; Didier, Peter J; Plauche, Gail et al. (2016) Septicemia in an Indian Rhesus Macaque (Macaca mulatta) associated with Providencia stuartii. J Med Primatol :

Showing the most recent 10 out of 315 publications