This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. INTRODUCTION: Concerns regarding alopecia in nonhuman primates are justified given that hair performs many essential functions. METHODS: The occurrence of alopecia is often attributed to the level of psychological wellbeing, and behavioral causes have become a routine, unconfirmed default diagnosis for alopecia in captive nonhuman primates. However, before attributing alopecia to abnormal behavior, it is necessary to rule out medical causes of alopecia. In this study, a medical and behavioral assessment of animals with and without alopecia was performed with the aim of designing a guide to approaching cases of nonhuman primate alopecia. The well-established algorithm for evaluation of alopecia in companion animal species was used as the basis for the medical evaluation. In addition, a behavioral evaluation was used to assess animals for the presence or absence of hair plucking. The hypothesis tested was that the commonly used diagnostic evaluation for alopecia in companion animal species is not applicable to nonhuman primates. RESULTS/DISCUSSION: Aside from the histopathology and behavioral assessment differences, few clinically relevant significant differences were found between animals with alopecia and control animals. As a result, the hypothesis was confirmed and we determined that application of the diagnostic plan for alopecia that is used in companion animal species to nonhuman primates is a practice that needs to be reexamined.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000164-50
Application #
8358126
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2011-05-01
Project End
2012-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
50
Fiscal Year
2011
Total Cost
$37,186
Indirect Cost
Name
Tulane University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
053785812
City
New Orleans
State
LA
Country
United States
Zip Code
70118
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