This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Dermal fibroblasts grafted in the globus pallidus have been shown to modulate the neuronal activity and improve motor behavior in rodent models of Parkinson's disease. In this project, we will study the transplantation of fibroblasts into the globus pallidus of parkinsonian monkeys to evaluate effects on parkinsonian symptoms. We plan to obtain fibroblast from skin biopsy and subsequently culture the cells for grafting.
In aim 1, we plan to test the accuracy of location of the graft using microelectrode-guided mapping of basal ganglia regions in a normal monkey.
In Aim 2, the fibroblast transplantation will be carried out in MPTP parkinsonian monkeys. In these parkinsonian monkeys, tests of levodopa-induced dyskinesias will be preformed for three months after the transplantation. These animals will be sacrificed at the end of the behavioral testing period. This project has just started with Aim 1.
|Maddox, S A; Kilaru, V; Shin, J et al. (2017) Estrogen-dependent association of HDAC4 with fear in female mice and women with PTSD. Mol Psychiatry :|
|Banerjee, Sunayana B; Gutzeit, Vanessa A; Baman, Justin et al. (2017) Perineuronal Nets in the Adult Sensory Cortex Are Necessary for Fear Learning. Neuron 95:169-179.e3|
|Bruner, Emiliano; Preuss, Todd M; Chen, Xu et al. (2017) Evidence for expansion of the precuneus in human evolution. Brain Struct Funct 222:1053-1060|
|Chen, Guiqin; Nie, Shuke; Han, Chao et al. (2017) Antidyskinetic Effects of MEK Inhibitor Are Associated with Multiple Neurochemical Alterations in the Striatum of Hemiparkinsonian Rats. Front Neurosci 11:112|
|Dehkharghani, S; Fleischer, C C; Qiu, D et al. (2017) Cerebral Temperature Dysregulation: MR Thermographic Monitoring in a Nonhuman Primate Study of Acute Ischemic Stroke. AJNR Am J Neuroradiol 38:712-720|
|Walker, Lary C; Jucker, Mathias (2017) The Exceptional Vulnerability of Humans to Alzheimer's Disease. Trends Mol Med 23:534-545|
|Payne, Christa; Cirilli, Laetitia; Bachevalier, Jocelyne (2017) An MRI study of the corpus callosum in monkeys: Developmental trajectories and effects of neonatal hippocampal and amygdala lesions. Dev Psychobiol 59:495-506|
|Tedesco, Dana; Thapa, Manoj; Gumber, Sanjeev et al. (2017) CD4(+) Foxp3(+) T cells promote aberrant immunoglobulin G production and maintain CD8(+) T-cell suppression during chronic liver disease. Hepatology 65:661-677|
|Hecht, E E; Mahovetz, L M; Preuss, T M et al. (2017) A neuroanatomical predictor of mirror self-recognition in chimpanzees. Soc Cogn Affect Neurosci 12:37-48|
|Fonseca, Jairo A; McCaffery, Jessica N; Kashentseva, Elena et al. (2017) A prime-boost immunization regimen based on a simian adenovirus 36 vectored multi-stage malaria vaccine induces protective immunity in mice. Vaccine 35:3239-3248|
Showing the most recent 10 out of 880 publications