This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Natural transmission of HIV occurs through mucosal surfaces at low efficiency, but few SIV vaccine studies have examined protective immunity under conditions designed to model these conditions. We investigated the efficacy of a multigenic DNA/MVA prime/boost vaccination regimen to induce mucosal immune responses to SIV and protect against repeated low-dose vaginal SIV challenge.
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