This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Hepatitis A virus (HAV), a NIAID Category B priority agent, is perhaps the most common cause of infectious jaundice globally despite the availability of an effective vaccine that can prevent liver disease when administered before or even after exposure to the virus. HAV infection rates in many countries including the United States have been reduced by widespread childhood vaccination but the potential for large-scale food or waterborne HAV outbreaks remains. Natural immunity to this virus is poorly understood. HAV infection is usually cleared within 5-7 weeks of infection. Relapsing hepatitis can occur within 4-16 weeks of symptom resolution in some individuals. Despite the potential for relapse that can prolong liver disease for up to one year, HAV cannot establish persistent infection like HCV, a flavivirus that causes chronic hepatitis in about 70% of infected individuals. This is a relatively short-term pilot study to understand the nature of protective immune responses to the hepatitis A virus. Our plan is to challenge two animals intravenously with 100 CID (chimpanzee infectious does) of HAV HM175 strain. Innate and adaptive immunity will then be monitored in blood and liver for 6 months as described in the Table of Samples and Procedures provided below. The animals will terminate the infection, approximately 5-8 weeks after challenge. The study may provide insight into mechanisms of successful viral immunity in the liver in a species that is highly relevant to humans.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR013986-13
Application #
8357674
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2011-05-01
Project End
2012-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
13
Fiscal Year
2011
Total Cost
$75,957
Indirect Cost
Name
Texas Biomedical Research Institute
Department
Type
DUNS #
007936834
City
San Antonio
State
TX
Country
United States
Zip Code
78245
Kumar, Shyamesh; Laurence, Hannah; Owston, Michael A et al. (2017) Natural pathology of the captive chimpanzee (Pan troglodytes): A 35-year review. J Med Primatol 46:271-290
Morosco, Danielle T; Cline, Curtis R; Owston, Michael A et al. (2017) Spontaneous mediastinal myeloid sarcoma in a common marmoset (Callithrix jacchus) and review of the veterinary literature. J Med Primatol 46:42-47
Muralimanoharan, Sribalasubashini; Li, Cun; Nakayasu, Ernesto S et al. (2017) Sexual dimorphism in the fetal cardiac response to maternal nutrient restriction. J Mol Cell Cardiol 108:181-193
Rodriguez-Sanchez, Iram P; Guindon, Josee; Ruiz, Marco et al. (2016) The endocannabinoid system in the baboon (Papio spp.) as a complex framework for developmental pharmacology. Neurotoxicol Teratol 58:23-30
Neidig, Lauren E; Owston, Michael A; Ball, Erin et al. (2016) Pauci-immune glomerulonephritis in a captive chimpanzee (Pan troglodytes), and a review of spontaneous cases in animals. J Med Primatol 45:336-341
Gharpure, Poorva; Kontogiorgos, Elias D; Opperman, Lynne A et al. (2016) Elastic Properties of Chimpanzee Craniofacial Cortical Bone. Anat Rec (Hoboken) 299:1718-1733
Schlabritz-Loutsevitch, Natalia; Gygax, Scott E; Dick Jr, Edward et al. (2016) Vaginal Dysbiosis from an Evolutionary Perspective. Sci Rep 6:26817
Ákos Szabó, C; Salinas, Felipe S; Li, Karl et al. (2016) Modeling the effective connectivity of the visual network in healthy and photosensitive, epileptic baboons. Brain Struct Funct 221:2023-33
Schlabritz-Loutsevitch, Natalia E; Comuzzie, Anthony G; Mahaney, Michael M et al. (2016) Serum Vitamin D Concentrations in Baboons (Papio spp.) during Pregnancy and Obesity. Comp Med 66:137-42
Bauer, Cassondra; Harrison, Tara (2016) Retrospective Analysis of the Incidence of Retained Placenta in 3 Large Colonies of NHP. Comp Med 66:143-9

Showing the most recent 10 out of 429 publications