Since 1978, the Center on the Etiology and Treatment of Alcohol Dependence (University of Connecticut ARC) has been devoted to a systematic exploration of the etiology and the treatment of alcohol dependence. This P60 application requests five years of continued funding for the Center's research programs on vulnerability to alcohol dependence and promising biological and psychosocial treatment interventions. Component I describes the University of Connecticut ARC's organizational framework, quality control mechanisms related to research and publications, and core research facilities. A visiting scholars program, consulting and mentoring activities, and journal editorship activities are described that strengthen the role of the University of Connecticut ARC as a regional and national resource. Component II focuses on the use of neurophysiologic, genetic and psychological factors to predict treatment outcome among conduct disordered adolescents receiving treatment for alcohol and substance abuse problems. This study continues the Center's focus on the etiology of alcohol use problems by focusing on high risk, early onset alcohol use and problematic high risk youth. Component III, a second study of vulnerability, will focus on several stress-related pathways that may increase the susceptibility for developing heavy drinking and alcohol-related problems among college students. This study will examine simultaneously the roles of learned and genetic risk factors for college student drinking in response to stress and affect-related triggers. Continuing our Center's emphasis on novel treatments for alcohol dependence, we propose two research components in this area. Component IV builds upon current work and will evaluate the efficacy of prize-based CM administered over 12 versus 24 weeks as well as the effect of different probabilities and magnitudes of reinforcement upon treatment outcomes. Component V is a placebo controlled trial of topiramate and will evaluate the safety and efficacy of topiramate (TOP) in combination with medical management (MM). Reductions in drinking, the persistence of treatment effects, and the role of GABA alleles and glutamate receptors in moderating the response to TOP will also be examined. Component VI describes a program of translational, dissemination and educational activities that are integrated with the Center's theme, investigators, and research programs. Finally, the proposed pilot studies component (VII) will support six studies that relate directly to the Center's themes of vulnerability and novel treatments for alcohol dependence.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA003510-35
Application #
8205922
Study Section
Special Emphasis Panel (ZAA1-BB (11))
Program Officer
Huebner, Robert B
Project Start
1978-03-01
Project End
2012-11-30
Budget Start
2011-12-01
Budget End
2012-11-30
Support Year
35
Fiscal Year
2012
Total Cost
$1,680,402
Indirect Cost
$472,799
Name
University of Connecticut
Department
Psychiatry
Type
Schools of Medicine
DUNS #
022254226
City
Farmington
State
CT
Country
United States
Zip Code
06030
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Armeli, Stephen; Covault, Jonathan; Tennen, Howard (2018) Long-term changes in the effects of episode-specific drinking to cope motivation on daily well-being. Psychol Addict Behav 32:715-726
Higgins-Biddle, John C; Babor, Thomas F (2018) A review of the Alcohol Use Disorders Identification Test (AUDIT), AUDIT-C, and USAUDIT for screening in the United States: Past issues and future directions. Am J Drug Alcohol Abuse 44:578-586
Petry, Nancy M; Zajac, Kristyn; Ginley, Meredith K (2018) Behavioral Addictions as Mental Disorders: To Be or Not To Be? Annu Rev Clin Psychol 14:399-423
Lieberman, Richard; Kranzler, Henry R; Levine, Eric S et al. (2018) Examining the effects of alcohol on GABAA receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells. Alcohol 66:45-53
Bauer, Lance O (2018) Inter-trial variability in brain activity as an indicator of synergistic effects of HIV-1 and drug abuse. Drug Alcohol Depend 191:300-308
Rash, Carla J; Petry, Nancy M; Alessi, Sheila M (2018) A randomized trial of contingency management for smoking cessation in the homeless. Psychol Addict Behav 32:141-148
Bauer, Lance O (2018) HIV/AIDS and an overweight body mass are associated with excessive intra-individual variability in response preparation. J Neurovirol 24:577-586
Petry, Nancy M; Alessi, Sheila M; Rash, Carla J et al. (2018) A randomized trial of contingency management reinforcing attendance at treatment: Do duration and timing of reinforcement matter? J Consult Clin Psychol 86:799-809
Petry, Nancy M; Ginley, Meredith K; Rash, Carla J (2017) A systematic review of treatments for problem gambling. Psychol Addict Behav 31:951-961

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