One goal of the proposed study is to evaluate the connections of three genes implicated in risk for externalizing disorders to: (1) impairments in specific domains of brain function that have also been implicated in risk for these disorders;and (2) an impairment in the maturation of these domains. Another goal is to evaluate the shared connections of the genes and brain dysfunction to both body mass/adiposity and alcoholism risk.
The specific aims are: 1) To evaluate 150 giris, aged 14-16 yrs, and 150 giris, aged 16-18 yrs. The analysis will test for differences between the age cohorts in neurophysiological and behavioral signs of frontal and paralimbic brain function. The sample size of 300 establishes a foundation upon which we may, in a future application, build a longitudinal study and test for maturational change directly. 2) To test the associafion of neurophysiological and behavioral signs of frontal/paralimbic brain function, as well as their maturational change, with CHRM2, GABRA2, and ANKK1 gene polymorphisms. It is hypothesized that the genes will associate with different domains of dysfunction: (a) CHRM2 will primarily associate with impairments, and less change with age, in selective attention, working memory, and boredom susceptibility, (b) GABRA2 will primarily associate with motor impulsivity and response disinhibition, and less change in these domains with age. (c) The TaqlA and nearby polymorphisms in ANKK1 will primarily associate with reward seeking and response disinhibition, and less change in these domains with age. 3) To test the associations of the candidate genes, and neurophysiological and behavioral measures, with adiposity. An additional aim is to assess their association with various indicators of alcoholism risk, such as a smaller subjective response to alcohol and eariier ages at first use and first intoxication. It is hypothesized that all of the genetic and impulsivity measures will correlate with body mass/adiposity and alcoholism risk outcomes because all are indicators of an externalizing construct that promotes them.

Public Health Relevance

The proposed study focuses on a health outcome of growing public health significance-an overweight or obese body mass~and risk factors for alcoholism. A better understanding of the overlap of these disorders could be significant. It may suggest, for example, that alcoholism and obesity are both expressions of an underlying externalizing trait which therefore require similar prevention and treatment strategies.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA003510-37
Application #
8600996
Study Section
Special Emphasis Panel (ZAA1-GG)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
37
Fiscal Year
2014
Total Cost
$193,905
Indirect Cost
$67,993
Name
University of Connecticut
Department
Type
DUNS #
022254226
City
Farmington
State
CT
Country
United States
Zip Code
06030
Weiss, Nicole H; Bold, Krysten W; Sullivan, Tami P et al. (2017) Testing bidirectional associations among emotion regulation strategies and substance use: a daily diary study. Addiction 112:695-704
Petry, Nancy M; Ginley, Meredith K; Rash, Carla J (2017) A systematic review of treatments for problem gambling. Psychol Addict Behav 31:951-961
Bauer, L O; Houston, R J (2017) The value of instability: an investigation of intrasubject variability in brain activity among obese adolescent girls. Int J Obes (Lond) 41:1489-1495
Meredith, Steven E; Rash, Carla J; Petry, Nancy M (2017) Alcohol use disorders are associated with increased HIV risk behaviors in cocaine-dependent methadone patients. J Subst Abuse Treat 83:10-14
Chartier, Karen G; Hesselbrock, Michie N; Hesselbrock, Victor M (2017) Conclusion: Special issue on genetic and alcohol use disorder research with diverse racial/ethnic groups: Key findings and potential next steps. Am J Addict 26:532-537
Burch, Ashley E; Rash, Carla J; Petry, Nancy M (2017) Cocaine-using substance abuse treatment patients with and without HIV respond well to contingency management treatment. J Subst Abuse Treat 77:21-25
Rash, Carla J; Stitzer, Maxine; Weinstock, Jeremiah (2017) Contingency Management: New Directions and Remaining Challenges for An Evidence-Based Intervention. J Subst Abuse Treat 72:10-18
Rash, Carla J; Alessi, Sheila M; Petry, Nancy M (2017) Substance Abuse Treatment Patients in Housing Programs Respond to Contingency Management Interventions. J Subst Abuse Treat 72:97-102
Howland, Maryhope; Armeli, Stephen; Feinn, Richard et al. (2017) Daily emotional stress reactivity in emerging adulthood: temporal stability and its predictors. Anxiety Stress Coping 30:121-132
Lieberman, Richard; Kranzler, Henry R; Levine, Eric S et al. (2017) Examining FKBP5 mRNA expression in human iPSC-derived neural cells. Psychiatry Res 247:172-181

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