Evidence indicates a robust associafion between reports of drinking to cope with stress and alcohol use disorders (AUD) symptoms among young adults. Yet inconsistent findings have been observed for the association between life stress and drinking levels and genetic and social learning risk factors that modify this relafionship. One important reason for these weak findings, we believe, is the almost exclusive reliance on checklists to measure life stress, despite their questionable validity. Using a state-of-the-science interview assessment of life stress, and recruiting a large and well characterized sample of post-college young adults, the first aim of the proposed study is to determine whether 5-HTTLPR genotype S'allele carriers, individuals with strong positive alcohol outcome expectancies, and individuals with avoidance coping styles show stronger associations between life stress and drinking levels, coping-related drinking and AUD symptoms.
Our second aim i s to examine whether aspects of adult role attainment, such as enhanced coping and role related stress buffer and/or exacerbate the effects outlined in the first aim. We will also examine the moderating effects other relevant candidate genes. In this study, moderate to heavy drinking participants in our soon to be completed ARC college drinking study, who have provided DNA to address this study's aims, will be contacted approximately 5 years after participation in the college study (N after attrition = 950). They will complete an intensive semi-structured phone interview assessing chronic and epsiodic stress during the previous year, and a detailed assessment of post-college role attainment, role-related coping resources and role stress. Through an Internet-based survey they will also complete standard measues of alcohol outcome expectancies and avoidance coping style, and retropective reports of alcohol use quantity and frequency, reasons for drinking and AUD symptoms. Participants will then report their daily drinking and reasons for drinking in a 30-day Internet-based daily diary. Results from this study will be important in terms of identifying individuals at risk for stress-related drinking and development of AUDs in eariy adulthood.

Public Health Relevance

In view of the public health costs of alcohol abuse and dependence, the ability to identify young adults at high risk for continued problematic use during the transition to adulthood is critical. Findings from this study should increase our understanding of the interaction of psychological and genetic risk factors for risky drinking, abuse and dependence in young adulthood.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA003510-37
Application #
8600998
Study Section
Special Emphasis Panel (ZAA1-GG)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
37
Fiscal Year
2014
Total Cost
$249,630
Indirect Cost
$51,883
Name
University of Connecticut
Department
Type
DUNS #
022254226
City
Farmington
State
CT
Country
United States
Zip Code
06030
Petry, Nancy M; Alessi, Sheila M; Byrne, Shannon et al. (2015) Reinforcing adherence to antihypertensive medications. J Clin Hypertens (Greenwich) 17:33-8
O'Hara, Ross E; Armeli, Stephen; Tennen, Howard (2015) College students' drinking motives and social-contextual factors: Comparing associations across levels of analysis. Psychol Addict Behav 29:420-9
Petry, Nancy M; Alessi, Sheila M; Barry, Danielle et al. (2015) Standard magnitude prize reinforcers can be as efficacious as larger magnitude reinforcers in cocaine-dependent methadone patients. J Consult Clin Psychol 83:464-72
O'Hara, Ross E; Armeli, Stephen; Tennen, Howard (2014) College students' daily-level reasons for not drinking. Drug Alcohol Rev 33:412-9
O'Hara, Ross E; Armeli, Stephen; Tennen, Howard (2014) Drinking-to-cope motivation and negative mood-drinking contingencies in a daily diary study of college students. J Stud Alcohol Drugs 75:606-14
Andrade, Leonardo F; Barry, Danielle; Litt, Mark D et al. (2014) Maintaining high activity levels in sedentary adults with a reinforcement-thinning schedule. J Appl Behav Anal 47:523-36
Arias, Albert J; Covault, Jonathan; Feinn, Richard et al. (2014) A GABRA2 variant is associated with increased stimulation and 'high' following alcohol administration. Alcohol Alcohol 49:1-9
Weiss, Lindsay M; Petry, Nancy M (2014) Substance abuse treatment patients with early onset cocaine use respond as well to contingency management interventions as those with later onset cocaine use. J Subst Abuse Treat 47:146-50
Milivojevic, Verica; Feinn, Richard; Kranzler, Henry R et al. (2014) Variation in AKR1C3, which encodes the neuroactive steroid synthetic enzyme 3?-HSD type 2 (17?-HSD type 5), moderates the subjective effects of alcohol. Psychopharmacology (Berl) 231:3597-608
Kranzler, Henry R; Armeli, Stephen; Feinn, Richard et al. (2014) GRIK1 genotype moderates topiramate's effects on daily drinking level, expectations of alcohol's positive effects and desire to drink. Int J Neuropsychopharmacol 17:1549-56

Showing the most recent 10 out of 87 publications