The Pilot Component The Scripps Research Institute Alcohol Research Center- (TSRI-ARC) will provide a program for conducting pilot studies that advance the research agenda of the TSRI-ARC on neuroadaptive mechanisms associated with the transition from binge drinking to dependence and potentially generate independent grant applications relevant to the focus of the Center at Large. The principal goals of the Pilot Project Program are to enable the TSRI-ARC to explore new directions for innovative research related to the center's goals (Specific Aim 1) and to recruit scientists new to alcohol research into the field, thereby exposing center investigators to fresh perspectives and methods (Specific Aim 2). In general, it is expected that the Pilot projects will provide seed funding to qualified investigators to enable them to gather sufficient preliminary data to attract support for testing a new hypothesis through R01, R21, KO1 or similar mechanisms (or to eliminate a new hypothesis as not worth pursuing). Ultimately the aim of the Pilot Studies component is to provide the TSRI-ARC with a flexible means to develop and explore new research activities or directions and unique scientific opportunities that have the potential to evolve into independently-funded research projects. The proposed pilot studies are integrated into the overall TSRI-ARC program and involve innovative approaches, which will have translational impact across the research components. Emphasis has been placed, in the first two years, on studies that will develop innovative new exciting neurobiological approaches to neurocircuitry targets and on human translational studies for the neuroadapatations associated with excessive drinking and dependence. As demonstrated with the success of our previous Pilot programs, we anticipate that the results of the pilots will help launch innovative lines of research and in parallel new careers in the study of the neurobiology of alcoholism.

Public Health Relevance

The Pilot Component will provide a program for conducting pilot studies that advance the research agenda of the TSRI-ARC on neuroadaptive mechanisms associated with the transition from binge drinking to dependence and that potentially generate independent grant applications relevant to the focus of the Center at Large. We anticipate the results of the pilots will help launch innovative lines of research and, in parallel, new careers in the study of the neurobiology of alcoholism.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
3P60AA006420-30S1
Application #
8627357
Study Section
Special Emphasis Panel (ZAA1-GG)
Project Start
2013-03-01
Project End
2017-12-31
Budget Start
2013-03-01
Budget End
2013-12-31
Support Year
30
Fiscal Year
2013
Total Cost
$1,895
Indirect Cost
$895
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Kreisler, A D; Mattock, M; Zorrilla, E P (2018) The duration of intermittent access to preferred sucrose-rich food affects binge-like intake, fat accumulation, and fasting glucose in male rats. Appetite 130:59-69
Varodayan, F P; Khom, S; Patel, R R et al. (2018) Role of TLR4 in the Modulation of Central Amygdala GABA Transmission by CRF Following Restraint Stress. Alcohol Alcohol 53:642-649
McClatchy, Daniel B; Yu, Nam-Kyung; Martínez-Bartolomé, Salvador et al. (2018) Structural Analysis of Hippocampal Kinase Signal Transduction. ACS Chem Neurosci :
Berger, Anthony L; Henricks, Angela M; Lugo, Janelle M et al. (2018) The Lateral Habenula Directs Coping Styles Under Conditions of Stress via Recruitment of the Endocannabinoid System. Biol Psychiatry 84:611-623
Mason, Barbara J; Quello, Susan; Shadan, Farhad (2018) Gabapentin for the treatment of alcohol use disorder. Expert Opin Investig Drugs 27:113-124
Varodayan, Florence P; Sidhu, Harpreet; Kreifeldt, Max et al. (2018) Morphological and functional evidence of increased excitatory signaling in the prelimbic cortex during ethanol withdrawal. Neuropharmacology 133:470-480
Matzeu, Alessandra; Martin-Fardon, Rémi (2018) Drug Seeking and Relapse: New Evidence of a Role for Orexin and Dynorphin Co-transmission in the Paraventricular Nucleus of the Thalamus. Front Neurol 9:720
Sidhu, Harpreet; Kreifeldt, Max; Contet, Candice (2018) Affective Disturbances During Withdrawal from Chronic Intermittent Ethanol Inhalation in C57BL/6J and DBA/2J Male Mice. Alcohol Clin Exp Res 42:1281-1290
Ehlers, Cindy L; Wills, Derek; Gilder, David A (2018) A history of binge drinking during adolescence is associated with poorer sleep quality in young adult Mexican Americans and American Indians. Psychopharmacology (Berl) 235:1775-1782
Pavon, Francisco J; Serrano, Antonia; Sidhpura, Nimish et al. (2018) Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addict Biol 23:723-734

Showing the most recent 10 out of 211 publications