TheInformationDisseminationCoreofTheScrippsResearchInstituteAlcoholResearchCenter(TSRI-ARC) willdisseminatescientificresearchfindingsmadebyARClabstothepublicthrougheducationalandoutreach efforts and will particularly target NIAAA-identified ?Special Populations? (youth under age 21, college-age young adults, senior citizens, women, and ethnic and racial minorities) that have characteristics that make themmoresusceptibletothenegativeconsequencesofalcoholuse.Importantly,thesepopulationsalsoareat high risk for stress, the primary focus of TSRI-ARC.
Core Specific Aims are the 1) Development of curricula targeted to high-risk populations, 2) Expansion of internships targeted to high-risk populations, and 3) Outreachthroughenhancedsocialmediaandparenteducation.Thegoalsoftheseaimsaretototeachhigh- riskpopulationsandthosewhointeractwiththemhowthebrainisaffectedbyalcohol,theprogressionofthese effectswithcontinueduse,andtheconceptofthe?darkside?ofaddictionusingspecificexamplesfromTSRI- ARC laboratories, to directly interact with the community through laboratory tours and a continuation and expansionofourinternshipprogram,andtomaketheTSRI-ARCwebsitemoreaccessibletothepublicandto use it for communication between TSRI-ARC PIs as well as a critical resource for each of our curriculum efforts.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
2P60AA006420-35
Application #
9393655
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
2018-01-01
Budget End
2018-12-31
Support Year
35
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Matzeu, Alessandra; Terenius, Lars; Martin-Fardon, Remi (2018) Exploring Sex Differences in the Attenuation of Ethanol Drinking by Naltrexone in Dependent Rats During Early and Protracted Abstinence. Alcohol Clin Exp Res 42:2466-2478
Kononoff, Jenni; Melas, Philippe A; Kallupi, Marsida et al. (2018) Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood. Sci Rep 8:13893
Verheij, Michel M M; Contet, Candice; Karel, Peter et al. (2018) Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake. Biol Psychiatry 83:1024-1035
Schmeichel, Brooke E; Matzeu, Alessandra; Koebel, Pascale et al. (2018) Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats. Neuropsychopharmacology 43:2373-2382
Kononoff, Jenni; Kallupi, Marsida; Kimbrough, Adam et al. (2018) Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats. eNeuro 5:
Kreisler, A D; Mattock, M; Zorrilla, E P (2018) The duration of intermittent access to preferred sucrose-rich food affects binge-like intake, fat accumulation, and fasting glucose in male rats. Appetite 130:59-69
Varodayan, F P; Khom, S; Patel, R R et al. (2018) Role of TLR4 in the Modulation of Central Amygdala GABA Transmission by CRF Following Restraint Stress. Alcohol Alcohol 53:642-649
McClatchy, Daniel B; Yu, Nam-Kyung; Martínez-Bartolomé, Salvador et al. (2018) Structural Analysis of Hippocampal Kinase Signal Transduction. ACS Chem Neurosci :
Berger, Anthony L; Henricks, Angela M; Lugo, Janelle M et al. (2018) The Lateral Habenula Directs Coping Styles Under Conditions of Stress via Recruitment of the Endocannabinoid System. Biol Psychiatry 84:611-623
Mason, Barbara J; Quello, Susan; Shadan, Farhad (2018) Gabapentin for the treatment of alcohol use disorder. Expert Opin Investig Drugs 27:113-124

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