The themes of the Indiana Alcohol Research Center (IARC) renewal """"""""Genetics of Alcoholism and Responses to Alcohol"""""""" are to identify correlates between risk factors (e.g., a positive family history of alcohol use disorders (AUD), externalizing behaviors (including different forms of impulsive behavior), patterns of binge drinking, and GABRA2 alleles) and: 1) measures of craving alcohol (assessed by operant work for alcohol using paradigms we have developed for both animals and humans), and 2) brain responses to novel cues conditioned to alcohol intoxication.
Our aims will advance NIAAA's goal of identifying the physiological traits of alcohol risk endophenotypes. We will extend our knowledge of the basis for alcohol preference in rats by sequencing the genomes of P/NP and HAD/LAD rats and defining the sequences resulting from selective breeding. With these complementary, parallel investigations, our Center fulfills a critical need to integrate human and animal studies of how risk genes affect responses and endophenotypes related to AUDs. The rationale for continuing our Center is that: 1) by working in close association across scientific disciplines spanning behavioral neuroscience, neuroanatomy, molecular biology, genetics, genomics, biochemistry, neurobiology, and bioinformatics, our investigators can achieve insights that are not possible when working in isolation, 2) the Center has made unique contributions to alcoholism research and dissemination of resources around the world, 3) it combines human and animal studies examining overlapping risk factors for AUDs, and 4) it provides an unparalleled multi-disciplinary training environment for students, fellows, and young faculty. The expected outcome of our combined work, in toto, is a far greater understanding of the relationship between genetic and behavioral risk factors for AUDs, as well as the mechanisms through which these genetic factors act. The positive impact of such knowledge will be the ability to better target future prevention and treatment strategies, and to advance our understanding of factors influencing how the human brain governs the approach toward, consumption of, response to, and eventually dependence upon alcohol intoxication. These outcomes will be achieved through the activities and interactions of Administrative, Animal Production, and Genomics and Bioinformatics Cores, a Pilot Projects and Translational Research and Science Education Component, and five research Components: two carrying out cutting edge translational human research with alcohol infusion technology invented by IARC researchers, and three using animal models created and characterized by IARC investigators.

Public Health Relevance

This work will provide novel information about the ways several risk factors for alcohol use disorders, such as family history of alcoholism, personality traits, and certain specific genes, modify responses to alcohol and increase the chances of developing problems with drinking.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZAA1-GG (50))
Program Officer
Murray, Gary
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Indiana University-Purdue University at Indianapolis
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Ding, Zheng-Ming; Ingraham, Cynthia M; Hauser, Sheketha R et al. (2017) Reduced Levels of mGlu2 Receptors within the Prelimbic Cortex Are Not Associated with Elevated Glutamate Transmission or High Alcohol Drinking. Alcohol Clin Exp Res 41:1896-1906
Hendershot, Christian S; Wardell, Jeffrey D; McPhee, Matthew D et al. (2017) A prospective study of genetic factors, human laboratory phenotypes, and heavy drinking in late adolescence. Addict Biol 22:1343-1354
Czachowski, Cristine L; Froehlich, Janice C; DeLory, Michael (2017) The Effects of Long-Term Varenicline Administration on Ethanol and Sucrose Seeking and Self-Administration in Male P Rats. Alcohol Clin Exp Res :
Linsenbardt, David N; Smoker, Michael P; Janetsian-Fritz, Sarine S et al. (2017) Impulsivity in rodents with a genetic predisposition for excessive alcohol consumption is associated with a lack of a prospective strategy. Cogn Affect Behav Neurosci 17:235-251
Froehlich, Janice C; Fischer, Stephen M; Nicholson, Emily R et al. (2017) A Combination of Naltrexone + Varenicline Retards the Expression of a Genetic Predisposition Toward High Alcohol Drinking. Alcohol Clin Exp Res 41:644-652
Weera, Marcus M; Fields, Molly A; Tapp, Danielle N et al. (2017) Effects of Nicotine on Alcohol Drinking in Female Mice Selectively Bred for High or Low Alcohol Preference. Alcohol Clin Exp Res :
Froehlich, Janice C; Nicholson, Emily R; Dilley, Julian E et al. (2017) Varenicline Reduces Alcohol Intake During Repeated Cycles of Alcohol Reaccess Following Deprivation in Alcohol-Preferring (P) Rats. Alcohol Clin Exp Res 41:1510-1517
Liang, Tiebing; Chalasani, Naga P; Williams, Kent Edward et al. (2017) Differential Expression of miRNAs in Nontumor Liver Tissue of Patients With Hepatocellular Cancer Caused by Nonalcoholic Steatohepatitis Cirrhosis. Clin Gastroenterol Hepatol 15:465-467
Gowin, Joshua L; Sloan, Matthew E; Stangl, Bethany L et al. (2017) Vulnerability for Alcohol Use Disorder and Rate of Alcohol Consumption. Am J Psychiatry 174:1094-1101
King, Andrea C; Hasin, Deborah; O'Connor, Sean J et al. (2016) A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder. Biol Psychiatry 79:489-98

Showing the most recent 10 out of 280 publications