Alcohol use disorders (AUDs) are enormous public health problems, but there confinues to be a gap between scienfific knowledge about AUDs and the knowledge base of the health care and justice system workforces. Further, there has been erosion within the legal community of the understanding of the legal theory covering the status of animals in agriculture and in research. The increasing amount of electronic data related to AUDs is fragmented and not easily accessible to health care workers. Further, there are emerging issues within the legal community of the understanding of the legal theories covering biomedical research involving human and animal subjects. There is a crifical need to improve the understanding of alcoholism as a disease by health care providers and members of the judicial system, to improve the recognifion of AUDs through screening approaches, and to facilitate animal research supporting our understanding of AUDs. The objective and long term goal of the Translafional Research and Science Educafion component has been to advance alcoholism research to prevent alcohol-related problems and improve the treatment of alcohol-afflicted individuals. Our central hypotheses are threefold: 1) that by improving the educafion of health care providers regarding AUDs and providing them with real fime informaflon about their paflents'problems with alcohol use, we will improve care and decrease the harm related to alcohol abuse;2) that by educaflng members of the judicial system about research in AUDs, we will improve: (a) the handling of legal cases related to alcohol and (b) the court orders regarding the ability of researchers to carry out research requiring certificates of confidentiality;3) that dissemination of legal theory related to animals'status as property to law students and judges will counter the efforts of animal rights activists to block the use of animals in research.
The specific aims of this component will address each of these needs, extending established educafional programs and taking advantage of unique medical informaflcs competencies of the IU School of Medicine and Regenstrief Institute.

Public Health Relevance

Alcohol use disorders have a huge impact on health and society. The Translational Science and Education Component will address this through education of medical students, residents, social workers, and members of the legal professions and use of electronic health records to identify patients earlier in their course.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA007611-27
Application #
8601014
Study Section
Special Emphasis Panel (ZAA1-GG)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
27
Fiscal Year
2014
Total Cost
$50,942
Indirect Cost
$18,394
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Wardell, Jeffrey D; Ramchandani, Vijay A; Hendershot, Christian S (2016) Drinking Motives Predict Subjective Effects of Alcohol and Alcohol Wanting and Liking During Laboratory Alcohol Administration: A Mediated Pathway Analysis. Alcohol Clin Exp Res 40:2190-2198
McClintick, Jeanette N; McBride, William J; Bell, Richard L et al. (2016) Gene Expression Changes in Glutamate and GABA-A Receptors, Neuropeptides, Ion Channels, and Cholesterol Synthesis in the Periaqueductal Gray Following Binge-Like Alcohol Drinking by Adolescent Alcohol-Preferring (P) Rats. Alcohol Clin Exp Res 40:955-68
Yoder, Karmen K; Albrecht, Daniel S; Dzemidzic, Mario et al. (2016) Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics. Drug Alcohol Depend 160:163-9
Bell, R L; Hauser, S; Rodd, Z A et al. (2016) A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. Int Rev Neurobiol 126:179-261
Sari, Youssef; Toalston, Jamie E; Rao, P S S et al. (2016) Effects of ceftriaxone on ethanol, nicotine or sucrose intake by alcohol-preferring (P) rats and its association with GLT-1 expression. Neuroscience 326:117-25
Ding, Zheng-Ming; Ingraham, Cynthia M; Rodd, Zachary A et al. (2016) Alcohol drinking increases the dopamine-stimulating effects of ethanol and reduces D2 auto-receptor and group II metabotropic glutamate receptor function within the posterior ventral tegmental area of alcohol preferring (P) rats. Neuropharmacology 109:41-8
O'Tousa, David S; Grahame, Nicholas J (2016) Long-Term Alcohol Drinking Reduces the Efficacy of Forced Abstinence and Conditioned Taste Aversion in Crossed High-Alcohol-Preferring Mice. Alcohol Clin Exp Res 40:1577-85
King, Andrea C; Hasin, Deborah; O'Connor, Sean J et al. (2016) A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder. Biol Psychiatry 79:489-98
Beckwith, Steven Wesley; Czachowski, Cristine Lynn (2016) Alcohol-Preferring P Rats Exhibit Elevated Motor Impulsivity Concomitant with Operant Responding and Self-Administration of Alcohol. Alcohol Clin Exp Res 40:1100-10
Qiu, Bin; Bell, Richard L; Cao, Yong et al. (2016) Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight. J Genet Genomics 43:421-30

Showing the most recent 10 out of 267 publications