The Pilot Project Component, which has been an integral part of the Indiana Alcohol Research Center (lARC) since its inception, will continue through years 26-30 (2012-2017).This component is a mechanism for funding promising, innovative research projects, for attracting new investigators to the alcohol research field, for developing methodologies that can be used by investigators in the lARC as well as investigators all over the worid, and for exploring areas of long-range relevance to the overall aims of the lARC. The flexibility inherent in the Pilot Project mechanishn has allowed the lARC to respond rapidly to unique scientific opportunities as they have arisen and to support research projects with good potential for evolving into extramurally funded research programs. Extramural funding for new innovative research proposals is often difficult to obtain if a proposal is not supported by preliminary results, and yet, preliminary results cannot be generated without funding. This is the classic dilemma faced by investigators who wish to move into new research areas and young investigators who are early in their careers. The pilot project mechanism alleviates this problem. During the past 24 years, the Pilot Project Component has had a demonstrable stimulatory effect on the growth of alcohol research on campus. It has served as a catalyst for the development of new research programs which, in turn, expand the training and research opportunities available to our students and fellows. The tangible evidence of the growth and success of this component includes the strong publication records of the pilot project investigators and the impressive rate of success of pilot project investigators in obtaining extramural research funding after having received lARC pilot project support. We have, and will continue to, monitor these outcomes 2-3 times a year in order to assess the effectiveness of the component. The administrative Core is responsible for managing the pilot projects, which are under the direction of Jan Froehlich with input from other members of the Steering Committee (David Crabb, David Kareken, Larry Lumeng, Sean O'Connor) and senior members of the Internal Board of Scientific Advisors (Howard Edenberg, Ting Kai Li, and Bill McBride).

Public Health Relevance

Development of preliminary data through pilot projects is essential for continued research advances. The pilot project component provides resources for exploration of new ideas and attracting new investigators to alcohol research.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZAA1-GG)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Indiana University-Purdue University at Indianapolis
United States
Zip Code
Wardell, Jeffrey D; Ramchandani, Vijay A; Hendershot, Christian S (2016) Drinking Motives Predict Subjective Effects of Alcohol and Alcohol Wanting and Liking During Laboratory Alcohol Administration: A Mediated Pathway Analysis. Alcohol Clin Exp Res 40:2190-2198
McClintick, Jeanette N; McBride, William J; Bell, Richard L et al. (2016) Gene Expression Changes in Glutamate and GABA-A Receptors, Neuropeptides, Ion Channels, and Cholesterol Synthesis in the Periaqueductal Gray Following Binge-Like Alcohol Drinking by Adolescent Alcohol-Preferring (P) Rats. Alcohol Clin Exp Res 40:955-68
Yoder, Karmen K; Albrecht, Daniel S; Dzemidzic, Mario et al. (2016) Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics. Drug Alcohol Depend 160:163-9
Bell, R L; Hauser, S; Rodd, Z A et al. (2016) A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. Int Rev Neurobiol 126:179-261
Sari, Youssef; Toalston, Jamie E; Rao, P S S et al. (2016) Effects of ceftriaxone on ethanol, nicotine or sucrose intake by alcohol-preferring (P) rats and its association with GLT-1 expression. Neuroscience 326:117-25
Ding, Zheng-Ming; Ingraham, Cynthia M; Rodd, Zachary A et al. (2016) Alcohol drinking increases the dopamine-stimulating effects of ethanol and reduces D2 auto-receptor and group II metabotropic glutamate receptor function within the posterior ventral tegmental area of alcohol preferring (P) rats. Neuropharmacology 109:41-8
O'Tousa, David S; Grahame, Nicholas J (2016) Long-Term Alcohol Drinking Reduces the Efficacy of Forced Abstinence and Conditioned Taste Aversion in Crossed High-Alcohol-Preferring Mice. Alcohol Clin Exp Res 40:1577-85
King, Andrea C; Hasin, Deborah; O'Connor, Sean J et al. (2016) A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder. Biol Psychiatry 79:489-98
Beckwith, Steven Wesley; Czachowski, Cristine Lynn (2016) Alcohol-Preferring P Rats Exhibit Elevated Motor Impulsivity Concomitant with Operant Responding and Self-Administration of Alcohol. Alcohol Clin Exp Res 40:1100-10
Qiu, Bin; Bell, Richard L; Cao, Yong et al. (2016) Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight. J Genet Genomics 43:421-30

Showing the most recent 10 out of 267 publications