The Animal Core Component will oversee care and use of rhesus macaques (Macaca mulatta) used by CARC investigators to study the impact of alcohol consumption on SIV disease prevention, shedding, progression as affected by treatment with anti-retroviral drugs. In addition, this core will extend its expertise and coordination of data collection to satellite projects using our alcohol/SIV infection model and CARC projects. The purpose of this Animal Core Component will be to provide high quality care, treatment and monitoring of rhesus macaques and to coordinate studies in order to maximally utilize this precious and unique resource.
The Specific Aims of the Animal Core will be: 1) To perform all aspects of care, treatment and monitoring of rhesus macaques that will be used by Research Component and Pilot Research investigators of the CARC in order to study the impact of chronic alcohol consumption on SIV disease transmission, pathogenesis, progression and ART. 2) To coordinate experimental design protocols among CARC Research Components (and satellite projects) using our alcohol/SIV infection model in rhesus macaques. 3) To schedule and coordinate sample collections from rhesus macaques and their distribution to Lab Core, Research Component and Pilot Project personnel of the CARC for analysis. 4. To serve as a resource for investigators that want to study the impact of alcohol on HIV disease using NHP models. The Animal Core Director, Gregory J. Bagby, PhD, will oversee and coordinate the use of this precious animal resource. The day-to-day management of research involving macaques will be performed by Co-Director Jason Dufour, DVM, DACLAM at TNPRC. The Animal Core will draw upon the interests and expertise of several scientists within and outside the CARC in conducting alcohol research using the rhesus macaque model of HIV disease, and be responsive to the Intramural Center Committee (ICC) in prioritizing the long-term activities of this Core. The members of the ICC will have the authority to modify plans and determine if long-term goals or priorities should be altered. An overall goal of this Animal Core will be to enhance efficiency, quality control, cooperation, and flexibility of research participants in their pursuit of ARC

Public Health Relevance

The Animal Core Component of our Comprehensive Alcohol Research Center (CARC) will perform an essential role in supporting and coordinating care and use of rhesus macaques (Macaca mulatta) used by 5 Research Components and Pilot Projects that study the effect of chronic alcohol consumption on simian immunodeficiency virus (SIV) disease and its control by anti-retroviral therapy (ART). The SIV rhesus monkey model is broadly recognized for its similarities to HIV/AIDS in humans.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZAA1-BB (91))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Louisiana State Univ Hsc New Orleans
New Orleans
United States
Zip Code
Merrill, Livia C; Jones, Christopher W; Drury, Stacy S et al. (2017) The differential impact of oxytocin receptor gene in violence-exposed boys and girls. Int J Dev Neurosci 59:60-67
Byerley, Lauri O; Samuelson, Derrick; Blanchard 4th, Eugene et al. (2017) Changes in the gut microbial communities following addition of walnuts to the diet. J Nutr Biochem 48:94-102
Ruan, Sanbao; Cai, Yang; Ramsay, Alistair J et al. (2017) B cell and antibody responses in mice induced by a putative cell surface peptidase of Pneumocystis murina protect against experimental infection. Vaccine 35:672-679
Samuelson, Derrick R; Shellito, Judd E; Maffei, Vincent J et al. (2017) Alcohol-associated intestinal dysbiosis impairs pulmonary host defense against Klebsiella pneumoniae. PLoS Pathog 13:e1006426
Ng, Hang Pong; Jennings, Scott; Wang, Jack et al. (2017) Non-canonical Glucocorticoid Receptor Transactivation of gilz by Alcohol Suppresses Cell Inflammatory Response. Front Immunol 8:661
Duplanty, Anthony A; Simon, Liz; Molina, Patricia E (2017) Chronic Binge Alcohol-Induced Dysregulation of Mitochondrial-Related Genes in Skeletal Muscle of Simian Immunodeficiency Virus-Infected Rhesus Macaques at End-Stage Disease. Alcohol Alcohol 52:298-304
Simon, Liz; Siggins, Robert; Winsauer, Peter et al. (2017) Simian Immunodeficiency Virus Infection Increases Blood Ethanol Concentration Duration After Both Acute and Chronic Administration. AIDS Res Hum Retroviruses :
Goldsmith, Felicia; Guice, Justin; Page, Ryan et al. (2017) Obese ZDF rats fermented resistant starch with effects on gut microbiota but no reduction in abdominal fat. Mol Nutr Food Res 61:
Theall, Katherine P; Shirtcliff, Elizabeth A; Dismukes, Andrew R et al. (2017) Association Between Neighborhood Violence and Biological Stress in Children. JAMA Pediatr 171:53-60
Felker-Kantor, Erica; Wallace, Maeve; Theall, Katherine (2017) Living in violence: Neighborhood domestic violence and small for gestational age births. Health Place 46:130-136

Showing the most recent 10 out of 99 publications