There is a high rate of alcohol use among HIV-infected individuals, and chronic alcohol use has been associated with high-risk sexual behavior, and reduced efficacy and adherence to antiretroviral therapy (ART). Collectively, these factors contribute to the transmission of HIV. In previous studies using the alcohol-fed rhesus macaques infected with Simian Immunodeficiency Virus (SIV), we have shown that chronic alcohol use is associated with higer levels of SIV in peripheral blood and more rapid disease progression. Additionally, we have shown that alcohol induced changes in the immunological profile of the gut mucosa, resulting in higher levels of SIV replication in the gut and peripheral blood, while others have identified alcohol-associated immunological changes in several tissues during acute SIV infection. These observations have led us to hypothesize that alcohol consumption will change the cellular milieu in the genital and rectal mucosa, providing an environment conducive to HIV infection, early replication, and shedding in genital secretions. Further, we hypothesize that increased early viral replication in these tissues will reduce the efficacy of ART in post-exposure prophylaxis and the longitudinal control of genital HIV shedding. These hypotheses will be addressed using the well-established SIV-rhesus macaque model for HIV disease, through the following specific aims. (1) Test the prediction that chronic alcohol consumption changes the cellular milieu and cytokine expression in the rectal mucosa of male macaques and the vaginal and cervical mucosa of female macaques. (2)Test the prediction that chronic alcohol exposure impacts the early dynamics of SIV infection and reduces the efficacy of post-exposure prophylaxis therapy. (3)Test the prediction that alcohol consumption increases SIV content in genital secretions, thereby increasing transmission risk. (4) Test the prediction that alcohol consumption reduces the ability of ART to suppress genital SIV shedding.

Public Health Relevance

These studies will identify the impact alcohol consumption has on mucosal tissues susceptible to sexual transmission of HIV, and determine the efficacy of ART to reduce the risk of HIV transmission in the presence of chronic alcohol consumption. Because alcohol use is a modifiable behavior, these results will provide compelling evidence to limit alcohol consumption as a means to prevent HIV transmission.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Comprehensive Center (P60)
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Special Emphasis Panel (ZAA1-DD)
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Louisiana State Univ Hsc New Orleans
New Orleans
United States
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Merrill, Livia C; Jones, Christopher W; Drury, Stacy S et al. (2017) The differential impact of oxytocin receptor gene in violence-exposed boys and girls. Int J Dev Neurosci 59:60-67
Byerley, Lauri O; Samuelson, Derrick; Blanchard 4th, Eugene et al. (2017) Changes in the gut microbial communities following addition of walnuts to the diet. J Nutr Biochem 48:94-102
Ruan, Sanbao; Cai, Yang; Ramsay, Alistair J et al. (2017) B cell and antibody responses in mice induced by a putative cell surface peptidase of Pneumocystis murina protect against experimental infection. Vaccine 35:672-679
Samuelson, Derrick R; Shellito, Judd E; Maffei, Vincent J et al. (2017) Alcohol-associated intestinal dysbiosis impairs pulmonary host defense against Klebsiella pneumoniae. PLoS Pathog 13:e1006426
Ng, Hang Pong; Jennings, Scott; Wang, Jack et al. (2017) Non-canonical Glucocorticoid Receptor Transactivation of gilz by Alcohol Suppresses Cell Inflammatory Response. Front Immunol 8:661
Duplanty, Anthony A; Simon, Liz; Molina, Patricia E (2017) Chronic Binge Alcohol-Induced Dysregulation of Mitochondrial-Related Genes in Skeletal Muscle of Simian Immunodeficiency Virus-Infected Rhesus Macaques at End-Stage Disease. Alcohol Alcohol 52:298-304
Simon, Liz; Siggins, Robert; Winsauer, Peter et al. (2017) Simian Immunodeficiency Virus Infection Increases Blood Ethanol Concentration Duration After Both Acute and Chronic Administration. AIDS Res Hum Retroviruses :
Goldsmith, Felicia; Guice, Justin; Page, Ryan et al. (2017) Obese ZDF rats fermented resistant starch with effects on gut microbiota but no reduction in abdominal fat. Mol Nutr Food Res 61:
Theall, Katherine P; Shirtcliff, Elizabeth A; Dismukes, Andrew R et al. (2017) Association Between Neighborhood Violence and Biological Stress in Children. JAMA Pediatr 171:53-60
Felker-Kantor, Erica; Wallace, Maeve; Theall, Katherine (2017) Living in violence: Neighborhood domestic violence and small for gestational age births. Health Place 46:130-136

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