The Louisiana State University Health Sciences Center (LSUHSC) New Orleans Comprehensive Alcohol- HIV/AIDS Research Center (CARC) is a multi-institutional, multidisciplinary team of scientists from LSUHSC, the Tulane National Primate Research Center (TNPRC) and Tulane University School of Public Health and Tropical Medicine (TSPHTN), with a research focus on the interaction of alcohol use disorders (AUD), simian and Human Immunodeficiency Virus (SIV/HIV), and Antiretroviral Therapy (ART) in non- human primates (NHP) and human subjects. This renewal application showcases our accomplishments and defines the evolution and expansion of our research strategy to now include clinical studies that will facilitate bi-directional translational investigation of AUD, HIV/AIDS, and ART comorbid conditions and their exacerbation in an underserved cohort of persons living with HIV/AIDS (PLWHA). The CARC will provide and enhance the necessary infrastructure to perform longitudinal pre-clinical and clinical translational studies on the interaction of AUD with HIV/AIDS. An Administrative Core will provide oversight for all CARC activities. Five Research Components (RC), will focus on rarely studied female rhesus macaques (RC1 and RC2), and a cohort of underserved PLWHA a large percent being women (RC3, RC4, RC5). RC1 will study chronic binge alcohol (CBA)-mediated alterations in female genital mucosa. RC2 will investigate the mechanisms of altered muscle and adipose functional phenotype associated with metabolic dysfunction. RC3 will examine the interaction between the microbiota, and inflammaging in PLWHA with AUD. RC4 will identify the clinical associations between AUD and HIV-associated cancer pathogenesis. RC5 will study the combined impact of AUD and chronic social and environmental stress on disease-related biological outcomes among PLWHA. Two Resource Cores -Experimental and Analytical- will provide support for studies proposed by all RC and Pilot Projects. An Information Dissemination Core will promote training and accelerate the translation and dissemination of CARC research findings to the clinical arena. A Pilot Project Core will promote the development and exploration of novel research investigations, thereby maximizing the unique scientific opportunities provided by the CARC. The CARC will continue to leverage and synergize with existing resources including the Louisiana Clinical and Translational Science Center, Minority-Based Community Clinical Oncology Program, and the LSUHSC Stanley S. Scott Cancer Center. Together, access to a unique HIV+ population in a Southeast urban region, the established expertise of CARC investigators in biomedical and behavioral research, state of the art research facilities, outstanding scientific environment, and strong institutional support will ensure that the proposed activities within the LSUHSC CARC will continue to be successful as we evolve and mature in our approach to understanding the comorbid consequences of AUD, HIV/SIV, and ART in PLWHA.

Public Health Relevance

The LSUHSC Comprehensive Alcohol-HIV/AIDS Research Center (CARC) is a multi-institutional, multidisciplinary team of scientists focused on understanding the interaction of alcohol use disorders (AUD) and HIV disease. CARC activities encompass basic and clinical translational research, training, mentoring, and information dissemination.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA009803-24
Application #
9182840
Study Section
Special Emphasis Panel (ZAA1)
Program Officer
Wang, Joe
Project Start
1996-12-01
Project End
2019-11-30
Budget Start
2016-12-01
Budget End
2017-11-30
Support Year
24
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Louisiana State Univ Hsc New Orleans
Department
Physiology
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
Merrill, Livia C; Jones, Christopher W; Drury, Stacy S et al. (2017) The differential impact of oxytocin receptor gene in violence-exposed boys and girls. Int J Dev Neurosci 59:60-67
Byerley, Lauri O; Samuelson, Derrick; Blanchard 4th, Eugene et al. (2017) Changes in the gut microbial communities following addition of walnuts to the diet. J Nutr Biochem 48:94-102
Ruan, Sanbao; Cai, Yang; Ramsay, Alistair J et al. (2017) B cell and antibody responses in mice induced by a putative cell surface peptidase of Pneumocystis murina protect against experimental infection. Vaccine 35:672-679
Samuelson, Derrick R; Shellito, Judd E; Maffei, Vincent J et al. (2017) Alcohol-associated intestinal dysbiosis impairs pulmonary host defense against Klebsiella pneumoniae. PLoS Pathog 13:e1006426
Ng, Hang Pong; Jennings, Scott; Wang, Jack et al. (2017) Non-canonical Glucocorticoid Receptor Transactivation of gilz by Alcohol Suppresses Cell Inflammatory Response. Front Immunol 8:661
Duplanty, Anthony A; Simon, Liz; Molina, Patricia E (2017) Chronic Binge Alcohol-Induced Dysregulation of Mitochondrial-Related Genes in Skeletal Muscle of Simian Immunodeficiency Virus-Infected Rhesus Macaques at End-Stage Disease. Alcohol Alcohol 52:298-304
Simon, Liz; Siggins, Robert; Winsauer, Peter et al. (2017) Simian Immunodeficiency Virus Infection Increases Blood Ethanol Concentration Duration After Both Acute and Chronic Administration. AIDS Res Hum Retroviruses :
Goldsmith, Felicia; Guice, Justin; Page, Ryan et al. (2017) Obese ZDF rats fermented resistant starch with effects on gut microbiota but no reduction in abdominal fat. Mol Nutr Food Res 61:
Theall, Katherine P; Shirtcliff, Elizabeth A; Dismukes, Andrew R et al. (2017) Association Between Neighborhood Violence and Biological Stress in Children. JAMA Pediatr 171:53-60
Felker-Kantor, Erica; Wallace, Maeve; Theall, Katherine (2017) Living in violence: Neighborhood domestic violence and small for gestational age births. Health Place 46:130-136

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