The Louisiana State University Health Sciences Center (LSUHSC) New Orleans Comprehensive Alcohol- HIV/AIDS Research Center (CARC) is a multi-institutional, multidisciplinary team of scientists from LSUHSC, the Tulane National Primate Research Center (TNPRC) and Tulane University School of Public Health and Tropical Medicine (TSPHTN), with a research focus on the interaction of alcohol use disorders (AUD), simian and Human Immunodeficiency Virus (SIV/HIV), and Antiretroviral Therapy (ART) in non- human primates (NHP) and human subjects. This renewal application showcases our accomplishments and defines the evolution and expansion of our research strategy to now include clinical studies that will facilitate bi-directional translational investigation of AUD, HIV/AIDS, and ART comorbid conditions and their exacerbation in an underserved cohort of persons living with HIV/AIDS (PLWHA). The CARC will provide and enhance the necessary infrastructure to perform longitudinal pre-clinical and clinical translational studies on the interaction of AUD with HIV/AIDS. An Administrative Core will provide oversight for all CARC activities. Five Research Components (RC), will focus on rarely studied female rhesus macaques (RC1 and RC2), and a cohort of underserved PLWHA a large percent being women (RC3, RC4, RC5). RC1 will study chronic binge alcohol (CBA)-mediated alterations in female genital mucosa. RC2 will investigate the mechanisms of altered muscle and adipose functional phenotype associated with metabolic dysfunction. RC3 will examine the interaction between the microbiota, and inflammaging in PLWHA with AUD. RC4 will identify the clinical associations between AUD and HIV-associated cancer pathogenesis. RC5 will study the combined impact of AUD and chronic social and environmental stress on disease-related biological outcomes among PLWHA. Two Resource Cores -Experimental and Analytical- will provide support for studies proposed by all RC and Pilot Projects. An Information Dissemination Core will promote training and accelerate the translation and dissemination of CARC research findings to the clinical arena. A Pilot Project Core will promote the development and exploration of novel research investigations, thereby maximizing the unique scientific opportunities provided by the CARC. The CARC will continue to leverage and synergize with existing resources including the Louisiana Clinical and Translational Science Center, Minority-Based Community Clinical Oncology Program, and the LSUHSC Stanley S. Scott Cancer Center. Together, access to a unique HIV+ population in a Southeast urban region, the established expertise of CARC investigators in biomedical and behavioral research, state of the art research facilities, outstanding scientific environment, and strong institutional support will ensure that the proposed activities within the LSUHSC CARC will continue to be successful as we evolve and mature in our approach to understanding the comorbid consequences of AUD, HIV/SIV, and ART in PLWHA.

Public Health Relevance

The LSUHSC Comprehensive Alcohol-HIV/AIDS Research Center (CARC) is a multi-institutional, multidisciplinary team of scientists focused on understanding the interaction of alcohol use disorders (AUD) and HIV disease. CARC activities encompass basic and clinical translational research, training, mentoring, and information dissemination.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA009803-24
Application #
9182840
Study Section
Special Emphasis Panel (ZAA1)
Program Officer
Wang, Joe
Project Start
1996-12-01
Project End
2019-11-30
Budget Start
2016-12-01
Budget End
2017-11-30
Support Year
24
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Louisiana State Univ Hsc New Orleans
Department
Physiology
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
Samuelson, Derrick R; Burnham, Ellen L; Maffei, Vincent J et al. (2018) The respiratory tract microbial biogeography in alcohol use disorder. Am J Physiol Lung Cell Mol Physiol 314:L107-L117
Glick, Jennifer L; Theall, Katherine P; Andrinopoulos, Katherine M et al. (2018) The Role of Discrimination in Care Postponement Among Trans-Feminine Individuals in the U.S. National Transgender Discrimination Survey. LGBT Health 5:171-179
Molina, Patricia E; Nelson, Steve (2018) Binge Drinking's Effects on the Body. Alcohol Res 39:99-109
Molina, Patricia E; Simon, Liz; Amedee, Angela M et al. (2018) Impact of Alcohol on HIV Disease Pathogenesis, Comorbidities and Aging: Integrating Preclinical and Clinical Findings. Alcohol Alcohol 53:439-447
Ford Jr, Stephen M; Simon Peter, Liz; Berner, Paul et al. (2018) Differential contribution of chronic binge alcohol and antiretroviral therapy to metabolic dysregulation in SIV-infected male macaques. Am J Physiol Endocrinol Metab :
Boule, Lisbeth A; Ju, Cynthia; Agudelo, Marisela et al. (2018) Summary of the 2016 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol 66:35-43
Glick, Jennifer L; Andrinopoulos, Katherine M; Theall, Katherine P et al. (2018) ""Tiptoeing Around the System"": Alternative Healthcare Navigation Among Gender Minorities in New Orleans. Transgend Health 3:118-126
Glick, Jennifer L; Theall, Katherine; Andrinopoulos, Katherine et al. (2018) For data's sake: dilemmas in the measurement of gender minorities. Cult Health Sex :1-16
Theall, Katherine P; Felker-Kantor, Erica; Wallace, Maeve et al. (2018) Considering high alcohol and violence neighborhood context using daily diaries and GPS: A pilot study among people living with HIV. Drug Alcohol Depend 187:236-241
Simon, Liz; Siggins, Robert; Winsauer, Peter et al. (2018) Simian Immunodeficiency Virus Infection Increases Blood Ethanol Concentration Duration After Both Acute and Chronic Administration. AIDS Res Hum Retroviruses 34:178-184

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