Scientific Resource Core The primary goal of the UNC Alcohol Research Center (ARC) is to increase understanding of the molecular and cellular pathogenesis in alcoholism. The purpose of the Scientific Resource Core (SRC) is to facilitate and extend this integrated research effort by providing access to cutting-edge technology, shared facilities, resources and technical expertise. In addition, the SRC fosters interaction among ARC investigators with the explicit purpose of increasing coordination and cohesiveness among individual research components. In this renewal application, the SRC has two specific goals. First, the SRC will support functional connectivity magnetic resonance imaging (fcMRI) studies designed to discover novel alcohol-induced changes in neural circuit connectivity, and activity, spanning multiple phases of addiction and mammalian species. This work will be conducted in an expert-driven environment within the SRC using shared facilities provided by the UNC Biomedical Research Imaging Center (BRIC). Access to cutting-edge imaging technologies and high end instrumentation in the BRIC significantly enhances the capabilities of Research Components by providing rigorous methods, sophisticated facilities, user support, and quality control of imaging. Second, the SRC provides facilities, resources, and expertise to allow measurement of alcohol-induced changes in gene and protein expression, and neural circuit function. These centralized facilities allow rigorous, standardized, and quality-controlled data collection across a variety of models, and extends the capability of Research Components to include novel methods. To assure effective functioning of the Core and to facilitate the integrative efforts of the ARC, the SRC holds a monthly meeting (chaired by Dr. Hodge) of ARC investigators that evaluates progress and provides a venue for data and idea sharing. Access to these resources, and integrative environment, is a highly significant feature of the ARC that contributes to the accomplishment of our shared goals. Together, these services and resources provide the Research Components with the unique capability of delineating alcohol-induced molecular changes in specific brain regions that are associated with altered neural circuit connectivity. This synergistic effort will provide novel insight into mechanisms of maladaptive changes in neural circuitry that underlie alcohol addiction. Moreover, this innovative and integrative strategy represents a clear advantage to conducting the proposed research as Center rather than separate research efforts.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Chapel Hill
United States
Zip Code
Broadwater, Margaret A; Lee, Sung-Ho; Yu, Yang et al. (2017) Adolescent alcohol exposure decreases frontostriatal resting-state functional connectivity in adulthood. Addict Biol :
Elton, Amanda; Smith, Christopher T; Parrish, Michael H et al. (2017) COMT Val158Met Polymorphism Exerts Sex-Dependent Effects on fMRI Measures of Brain Function. Front Hum Neurosci 11:578
Guillen-Sacoto, Maria J; Martinez, Ariel F; Abe, Yu et al. (2017) Human germline hedgehog pathway mutations predispose to fatty liver. J Hepatol 67:809-817
Coleman Jr, Leon G; Zou, Jian; Crews, Fulton T (2017) Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7. J Neuroinflammation 14:22
Radke, Anna K; Jury, Nicholas J; Kocharian, Adrina et al. (2017) Chronic EtOH effects on putative measures of compulsive behavior in mice. Addict Biol 22:423-434
Crews, Fulton T; Walter, T Jordan; Coleman Jr, Leon G et al. (2017) Toll-like receptor signaling and stages of addiction. Psychopharmacology (Berl) 234:1483-1498
Jaramillo, Anel A; Agan, Verda E; Makhijani, Viren H et al. (2017) Functional role for suppression of the insular-striatal circuit in modulating interoceptive effects of alcohol. Addict Biol :
Bohnsack, John Peyton; Patel, Vraj K; Morrow, A Leslie (2017) Ethanol Exposure Regulates Gabra1 Expression via Histone Deacetylation at the Promoter in Cultured Cortical Neurons. J Pharmacol Exp Ther 363:1-11
Madayag, Aric C; Stringfield, Sierra J; Reissner, Kathryn J et al. (2017) Sex and Adolescent Ethanol Exposure Influence Pavlovian Conditioned Approach. Alcohol Clin Exp Res 41:846-856
Salling, Michael C; Hodge, Christopher J; Psilos, Kelly E et al. (2017) Cue-induced reinstatement of alcohol-seeking behavior is associated with increased CaMKII T286 phosphorylation in the reward pathway of mice. Pharmacol Biochem Behav 163:20-29

Showing the most recent 10 out of 204 publications