This study extends currently ongoing research on both drinking and smoking (current Project 6) using ecological momentary assessment (EMA) to examine the use of alcohol with and without conjoint smoking to regulate emotions, and the effects of these regulation strategies on subsequent mood. We add a comparison group of Borderline Personality Disorder (BPD) patients. BPD exhibits high comorbidity with alcohol use disorders (AUDs) in both clinical and population-based samples. Cardinal symptoms of BPD, impulsivity and affective instability, are central constructs in theories of AUD etiology, so BPD represents a type of "model system" for studying the role of emotion regulation and disordered self-control in the genesis of AUD. We will collect EMA data from both random and event-based (e.g., drinking, smoking) assessments to address our aims. We will test the following hypotheses: (1) drinking episodes in BPD patients will be presaged by both positive and negative moods;drinking in non-affected controls (CON) will be presaged by positive but not negative moods;impulsivity will moderate these mood-substance use relations. (2) BPD patients'drinking episodes will be associated with heavier consumption (sex and body weight adjusted) than CON;group differences will be moderated by both affective instability and by impulsivity. Drinks consumed will be moderated by number of cigarettes in both groups. (3) Alcohol consumption's effect on mood will be characterized by both positive and negative reinforcement;smoking will attenuate the degree of reinforcement due to acute cross-tolerance effects in both groups. In BPD patients, underlying affective instability will attenuate the duration of alcohol-related, salutary effects on mood. (4) Negative post-drinking effects of alcohol on mood will be larger in BPD patients than controls because of additive effects of hedonic rebound effects of alcohol and negative affectivity in BPD patients;smoking will increase these effects in both groups. This study will provide important information about the role mood dysregulation plays in the etiology and maintenance of AUD, and how impulsivity and smoking may interact with mood dysregulation to lead to increased drinking. These results will have implications for both prevention and treatment of alcohol problems.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA011998-14
Application #
8375816
Study Section
Special Emphasis Panel (ZAA1-BB)
Project Start
Project End
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
14
Fiscal Year
2012
Total Cost
$301,933
Indirect Cost
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
van den Berg, Stéphanie M; de Moor, Marleen H M; Verweij, Karin J H et al. (2016) Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium. Behav Genet 46:170-82
Schwantes-An, Tae-Hwi; Zhang, Juan; Chen, Li-Shiun et al. (2016) Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet 46:151-69
Werner, K B; McCutcheon, V V; Challa, M et al. (2016) The association between childhood maltreatment, psychopathology, and adult sexual victimization in men and women: results from three independent samples. Psychol Med 46:563-73
Bailey, Kira; Bartholow, Bruce D (2016) Alcohol words elicit reactive cognitive control in low-sensitivity drinkers. Psychophysiology 53:1751-1759
Fleming, Kimberly A; Bartholow, Bruce D; Hilgard, Joseph et al. (2016) The Alcohol Sensitivity Questionnaire: Evidence for Construct Validity. Alcohol Clin Exp Res 40:880-8
Elam, Kit K; Wang, Frances L; Bountress, Kaitlin et al. (2016) Predicting substance use in emerging adulthood: A genetically informed study of developmental transactions between impulsivity and family conflict. Dev Psychopathol 28:673-88
Fleming, Kimberly A; Heintzelman, Samantha J; Bartholow, Bruce D (2016) Specifying Associations Between Conscientiousness and Executive Functioning: Mental Set Shifting, Not Prepotent Response Inhibition or Working Memory Updating. J Pers 84:348-60
Werner, K B; McCutcheon, V V; Agrawal, A et al. (2016) The association of specific traumatic experiences with cannabis initiation and transition to problem use: Differences between African-American and European-American women. Drug Alcohol Depend 162:162-9
Trull, Timothy J; Wycoff, Andrea M; Lane, Sean P et al. (2016) Cannabis and alcohol use, affect and impulsivity in psychiatric out-patients' daily lives. Addiction 111:2052-2059
Bailey, Kira; Amlung, Michael T; Morris, David H et al. (2016) Separate and joint effects of alcohol and caffeine on conflict monitoring and adaptation. Psychopharmacology (Berl) 233:1245-55

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