MOLECULAR EPIDEMIOLOGY OF ALCOHOLISM AND COMORBID DISORDERS This MARC research project, project 5, seeks to build upon gene-discovery projects such as COGA (Collaborative Study on the Genetics of Alcoholism: PI, Porjesz) and similar projects (e.g. Pis Hill, Kendler) which are studying treatment-ascertained alcoholics and their relatives, and the MARC-affiliated Alcohol-QTL IRPG consortium (Pis Heath, Martin, Madden, Todd), which is studying community-ascertained alcoholics and heavy smokers and their adult relatives, by incorporating a molecular genetic component into 5 prospective longitudinal studies (Pis Anokhin, Bucholz, Chassin, Heath, Sher: ABCHS Cohorts) spanning the age-range from early adolescence into young adulthood. In addition to completing DNA collection on the Heath cohort (years 1-2), this research project will conduct genotyping for a limited number of candidate genes (years 1-2);and DNA array genetic association analysis (years 3-5). We focus on a limited number of candidate phenotypes where prospective data are expected to be informative for understanding the etiology of alcoholism. The selection of the first candidate phenotypes and candidate genes is guided by the MARC focus on the roles of overlapping mechanisms of behavioral under-control, negative affect regulation and pharmacologic vulnerability in the etiology of alcohol use disorders (AUDs), emphasizing AUD phenotypes associated with (a) externalizing symptoms, (b) tolerance and quantitative consumption indices, (c) cooccurrence with tobacco dependence, and (d) negative affect. The second set of candidate genes will be selected from replicated genome-wide association (GWA) study results from COGA, Australian IRPG and other studies.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA011998-15
Application #
8475409
Study Section
Special Emphasis Panel (ZAA1-BB)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
15
Fiscal Year
2013
Total Cost
$276,899
Indirect Cost
$83,874
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Martins, Jorge S; Bartholow, Bruce D; Cooper, M Lynne et al. (2018) Associations between executive functioning, affect-regulation drinking motives, and alcohol use and problems. Psychol Addict Behav 32:16-28
Agrawal, A; Chou, Y-L; Carey, C E et al. (2018) Genome-wide association study identifies a novel locus for cannabis dependence. Mol Psychiatry 23:1293-1302
Micalizzi, Lauren; Marceau, Kristine; Brick, Leslie A et al. (2018) Inhibitory control in siblings discordant for exposure to maternal smoking during pregnancy. Dev Psychol 54:199-208
Werner, Kimberly B; Cunningham-Williams, Renee M; Sewell, Whitney et al. (2018) The Impact of Traumatic Experiences on Risky Sexual Behaviors in Black and White Young Adult Women. Womens Health Issues 28:421-429
Carpenter, Ryan W; Tragesser, Sarah L; Lane, Sean P et al. (2018) Momentary assessment of everyday physical pain in outpatients with borderline personality disorder. Personal Disord :
Bartholow, Bruce D; Fleming, Kimberly A; Wood, Phillip K et al. (2018) Alcohol effects on response inhibition: Variability across tasks and individuals. Exp Clin Psychopharmacol 26:251-267
Waldron, Mary; Watkins, Nicole K; Bucholz, Kathleen K et al. (2018) Interactive Effects of Maternal Alcohol Problems and Parental Separation on Timing of Daughter's First Drink. Alcohol Clin Exp Res 42:120-127
Acevedo, María Belén; Eagon, J Christopher; Bartholow, Bruce D et al. (2018) Sleeve gastrectomy surgery: when 2 alcoholic drinks are converted to 4. Surg Obes Relat Dis 14:277-283
Von Gunten, Curtis D; Volpert-Esmond, Hannah I; Bartholow, Bruce D (2018) Temporal dynamics of reactive cognitive control as revealed by event-related brain potentials. Psychophysiology 55:
Hepp, Johanna; Lane, Sean P; Wycoff, Andrea M et al. (2018) Interpersonal stressors and negative affect in individuals with borderline personality disorder and community adults in daily life: A replication and extension. J Abnorm Psychol 127:183-189

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