This study extends currently ongoing research on both drinking and smoking (current Project 6) using ecological momentary assessment (EMA) to examine the use of alcohol with and without conjoint smoking to regulate emotions, and the effects of these regulation strategies on subsequent mood. We add a comparison group of Borderline Personality Disorder (BPD) patients. BPD exhibits high comorbidity with alcohol use disorders (AUDs) in both clinical and population-based samples. Cardinal symptoms of BPD, impulsivity and affective instability, are central constructs in theories of AUD etiology, so BPD represents a type of """"""""model system"""""""" for studying the role of emotion regulation and disordered self-control in the genesis of AUD. We will collect EMA data from both random and event-based (e.g., drinking, smoking) assessments to address our aims. We will test the following hypotheses: (1) drinking episodes in BPD patients will be presaged by both positive and negative moods;drinking in non-affected controls (CON) will be presaged by positive but not negative moods;impulsivity will moderate these mood-substance use relations. (2) BPD patients'drinking episodes will be associated with heavier consumption (sex and body weight adjusted) than CON;group differences will be moderated by both affective instability and by impulsivity. Drinks consumed will be moderated by number of cigarettes in both groups. (3) Alcohol consumption's effect on mood will be characterized by both positive and negative reinforcement;smoking will attenuate the degree of reinforcement due to acute cross-tolerance effects in both groups. In BPD patients, underlying affective instability will attenuate the duration of alcohol-related, salutary effects on mood. (4) Negative post-drinking effects of alcohol on mood will be larger in BPD patients than controls because of additive effects of hedonic rebound effects of alcohol and negative affectivity in BPD patients;smoking will increase these effects in both groups. This study will provide important information about the role mood dysregulation plays in the etiology and maintenance of AUD, and how impulsivity and smoking may interact with mood dysregulation to lead to increased drinking. These results will have implications for both prevention and treatment of alcohol problems.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Comprehensive Center (P60)
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Special Emphasis Panel (ZAA1-BB)
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Washington University
Saint Louis
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Acevedo, María Belén; Eagon, J Christopher; Bartholow, Bruce D et al. (2017) Sleeve gastrectomy surgery: When 2 alcoholic drinks are converted to 4. Surg Obes Relat Dis :
Otto, Jacqueline M; Gizer, Ian R; Deak, Joseph D et al. (2017) A cis-eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use. Alcohol Clin Exp Res 41:929-938
Von Gunten, Curtis D; Volpert-Esmond, Hannah I; Bartholow, Bruce D (2017) Temporal dynamics of reactive cognitive control as revealed by event-related brain potentials. Psychophysiology :
Agrawal, A; Chou, Y-L; Carey, C E et al. (2017) Genome-wide association study identifies a novel locus for cannabis dependence. Mol Psychiatry :
Micalizzi, Lauren; Marceau, Kristine; Brick, Leslie A et al. (2017) Inhibitory Control in Siblings Discordant for Exposure to Maternal Smoking During Pregnancy. Dev Psychol :
Carpenter, Ryan W; Trela, Constantine J; Lane, Sean P et al. (2017) Elevated rate of alcohol consumption in borderline personality disorder patients in daily life. Psychopharmacology (Berl) 234:3395-3406
Martins, Jorge S; Bartholow, Bruce D; Cooper, M Lynne et al. (2017) Associations Between Executive Functioning, Affect-Regulation Drinking Motives, and Alcohol Use and Problems. Psychol Addict Behav :
Sadler, Brooke E; Grant, Julia D; Duncan, Alexis E et al. (2017) The Influence of Paternal Separation, Paternal History of Alcohol Use Disorder Risk, and Early Substance Use on Offspring Educational Attainment by Young Adulthood. J Stud Alcohol Drugs 78:426-434
Hone, Liana S E; Bartholow, Bruce D; Piasecki, Thomas M et al. (2017) Women's Alcohol Sensitivity Predicts Alcohol-Related Regretted Sex. Alcohol Clin Exp Res 41:1630-1636
Korucuoglu, Ozlem; Sher, Kenneth J; Wood, Phillip K et al. (2017) Acute alcohol effects on set-shifting and its moderation by baseline individual differences: a latent variable analysis. Addiction 112:442-453

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