The Robert Brigham Multidisciplinary Clinical Research Center (RBMCRC) is the principal resource for clinical, translational, epidemiological, health services and methodological research on rheumatologic and musculoskeletal conditions at the Brigham and Women's Hospital and throughout the Harvard Medical and Public Health communities. The Center is a hub for clinically- and policy-relevant, methodologically rigorous, interdisciplinary research to improve the outcomes of patients with musculoskeletal and rheumatologic disorders. The objectives of the Center are to: 1) Perform cutting edge research on rheumatologic and musculoskeletal problems in order to prevent these disorders, improve their management, enhance quality of life for patients with these problems and optimize provision of services for patients with rheumatic and musculoskeletal disorders. 2) Provide core methodologic and administrative resources and scientific leadership to catalyze such research among Center investigators and throughout the Center's research base. 3) Enhance the career development of younger investigators dedicated to the application of rigorous clinical research methodology to problems affecting the quality of life of persons with rheumatic and musculoskeletal disorders. The Center is structured around a Methodology Core, which ensures rigorous design and execution of research, and an Administrative Core, which provides effective scientific leadership, financial management and oversight. The Center proposes three projects: 1) """"""""Suboptimal outcomes of total knee replacement: Phenotypes and Risk factors;"""""""" 2) """"""""Rheumatic expertise expanded access to improve community health;"""""""" and, 3) """"""""Communication of biomarker, genetic and lifestyle risk factor profiles for RA to first degree relatives."""""""" Each ofthe projects applies rigorous methods to address pressing priorities in rheumatic and musculoskeletal disease: optimizing outcomes of total knee replacement, a procedure performed on more than 600,000 Americans each year;ensuring that primary care physicians and rheumatologist collaborate effectively to provide appropriate medications to patients with rheumatoid arthritis (RA);and anticipating the emergence of RA prevention by developing methods to communicate RA risk and preventive behavioral strategies to first degree relatives of persons with rheumatoid arthritis.

Public Health Relevance

The Robert Brigham Multidisciplinary Clinical Research Center is dedicated to methodologically rigorous, clinically relevant clinical research on rheumatic and musculoskeletal conditions. The Center proposes three projects relating to key priorities: optimizing outcomes of total knee replacement, ensuring appropriate treatment of rheumatoid arthritis (RA) and effectively communicating risk of RA to first degree relatives.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
5P60AR047782-12
Application #
8486395
Study Section
Special Emphasis Panel (ZAR1-KM (M1))
Program Officer
Witter, James
Project Start
2001-06-15
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
12
Fiscal Year
2013
Total Cost
$1,083,287
Indirect Cost
$473,698
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Katz, Jeffrey N; Smith, Savannah R; Yang, Heidi Y et al. (2017) Value of History, Physical Examination, and Radiographic Findings in the Diagnosis of Symptomatic Meniscal Tear Among Middle-Aged Subjects With Knee Pain. Arthritis Care Res (Hoboken) 69:484-490
Jain, Nitin B; Luz, Jennifer; Higgins, Laurence D et al. (2017) The Diagnostic Accuracy of Special Tests for Rotator Cuff Tear: The ROW Cohort Study. Am J Phys Med Rehabil 96:176-183
MacFarlane, L A; Yang, H; Collins, J E et al. (2017) Associations among meniscal damage, meniscal symptoms and knee pain severity. Osteoarthritis Cartilage 25:850-857
Hu, Yang; Sparks, Jeffrey A; Malspeis, Susan et al. (2017) Long-term dietary quality and risk of developing rheumatoid arthritis in women. Ann Rheum Dis 76:1357-1364
Sparks, Jeffrey A; Iversen, Maura D; Yu, Zhi et al. (2017) Disclosure of personalized rheumatoid arthritis risk using genetics, biomarkers, and lifestyle factors to motivate health behavior improvements:A randomized controlled trial. Arthritis Care Res (Hoboken) :
Solomon, Daniel H; Losina, Elena; Lu, Bing et al. (2017) Implementation of Treat-to-Target in Rheumatoid Arthritis Through a Learning Collaborative: Results of a Randomized Controlled Trial. Arthritis Rheumatol 69:1374-1380
Yu, Zhi; Lu, Bing; Agosti, Jenifer et al. (2017) Implementation of Treat to Target for Rheumatoid Arthritis in the US: Analysis of Baseline Data from the TRACTION Trial. Arthritis Care Res (Hoboken) :
Bengtsson, Camilla; Malspeis, Susan; Orellana, Cecilia et al. (2017) Association Between Menopausal Factors and the Risk of Seronegative and Seropositive Rheumatoid Arthritis: Results From the Nurses' Health Studies. Arthritis Care Res (Hoboken) 69:1676-1684
Sparks, Jeffrey A; Lin, Tzu-Chieh; Camargo Jr, Carlos A et al. (2017) Rheumatoid arthritis and risk of chronic obstructive pulmonary disease or asthma among women: A marginal structural model analysis in the Nurses' Health Study. Semin Arthritis Rheum :
Iversen, Maura D; Frits, Michelle; von Heideken, Johan et al. (2017) Physical Activity and Correlates of Physical Activity Participation Over Three Years in Adults With Rheumatoid Arthritis. Arthritis Care Res (Hoboken) 69:1535-1545

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