The Robert Brigham Multidisciplinary Clinical Research Center (RBMCRC) is the principal resource for clinical, translational, epidemiological, health services and methodological research on rheumatologic and musculoskeletal conditions at the Brigham and Women's Hospital and throughout the Harvard Medical and Public Health communities. The Center is a hub for clinically- and policy-relevant, methodologically rigorous, interdisciplinary research to improve the outcomes of patients with musculoskeletal and rheumatologic disorders. The objectives of the Center are to: 1) Perform cutting edge research on rheumatologic and musculoskeletal problems in order to prevent these disorders, improve their management, enhance quality of life for patients with these problems and optimize provision of services for patients with rheumatic and musculoskeletal disorders. 2) Provide core methodologic and administrative resources and scientific leadership to catalyze such research among Center investigators and throughout the Center's research base. 3) Enhance the career development of younger investigators dedicated to the application of rigorous clinical research methodology to problems affecting the quality of life of persons with rheumatic and musculoskeletal disorders. The Center is structured around a Methodology Core, which ensures rigorous design and execution of research, and an Administrative Core, which provides effective scientific leadership, financial management and oversight. The Center proposes three projects: 1) "Suboptimal outcomes of total knee replacement: Phenotypes and Risk factors;" 2) "Rheumatic expertise expanded access to improve community health;" and, 3) "Communication of biomarker, genetic and lifestyle risk factor profiles for RA to first degree relatives." Each ofthe projects applies rigorous methods to address pressing priorities in rheumatic and musculoskeletal disease: optimizing outcomes of total knee replacement, a procedure performed on more than 600,000 Americans each year;ensuring that primary care physicians and rheumatologist collaborate effectively to provide appropriate medications to patients with rheumatoid arthritis (RA);and anticipating the emergence of RA prevention by developing methods to communicate RA risk and preventive behavioral strategies to first degree relatives of persons with rheumatoid arthritis.

Public Health Relevance

The Robert Brigham Multidisciplinary Clinical Research Center is dedicated to methodologically rigorous, clinically relevant clinical research on rheumatic and musculoskeletal conditions. The Center proposes three projects relating to key priorities: optimizing outcomes of total knee replacement, ensuring appropriate treatment of rheumatoid arthritis (RA) and effectively communicating risk of RA to first degree relatives.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
5P60AR047782-12
Application #
8486395
Study Section
Special Emphasis Panel (ZAR1-KM (M1))
Program Officer
Witter, James
Project Start
2001-06-15
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
12
Fiscal Year
2013
Total Cost
$1,083,287
Indirect Cost
$473,698
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Ananthakrishnan, Ashwin N; Cagan, Andrew; Cai, Tianxi et al. (2016) Identification of Nonresponse to Treatment Using Narrative Data in an Electronic Health Record Inflammatory Bowel Disease Cohort. Inflamm Bowel Dis 22:151-8
Sparks, Jeffrey A; Karlson, Elizabeth W (2016) The Roles of Cigarette Smoking and the Lung in the Transitions Between Phases of Preclinical Rheumatoid Arthritis. Curr Rheumatol Rep 18:15
Kim, Seoyoung C; Kim, Dae Hyun; Mogun, Helen et al. (2016) Impact of the U.S. Food and Drug Administration's Safety-Related Announcements on the Use of Bisphosphonates After Hip Fracture. J Bone Miner Res 31:1536-40
Sparks, Jeffrey A; Chang, Shun-Chiao; Deane, Kevin D et al. (2016) Associations of Smoking and Age With Inflammatory Joint Signs Among Unaffected First-Degree Relatives of Rheumatoid Arthritis Patients: Results From Studies of the Etiology of Rheumatoid Arthritis. Arthritis Rheumatol 68:1828-38
Suter, Lisa G; Smith, Savannah R; Katz, Jeffrey N et al. (2016) Projecting Lifetime Risk of Symptomatic Knee Osteoarthritis and Total Knee Replacement in Individuals Sustaining a Complete Anterior Cruciate Ligament Tear in Early Adulthood. Arthritis Care Res (Hoboken) :
Solomon, Daniel H; Lee, Sara B; Zak, Agnes et al. (2016) Implementation of treat-to-target in rheumatoid arthritis through a Learning Collaborative: Rationale and design of the TRACTION trial. Semin Arthritis Rheum 46:81-7
Deshpande, Bhushan R; Losina, Elena; Smith, Savannah R et al. (2016) Association of MRI findings and expert diagnosis of symptomatic meniscal tear among middle-aged and older adults with knee pain. BMC Musculoskelet Disord 17:154
Ananthakrishnan, Ashwin N; Cagan, Andrew; Cai, Tianxi et al. (2016) Statin Use Is Associated With Reduced Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol 14:973-9
Katz, Jeffrey N; Smith, Savannah R; Yang, Heidi Y et al. (2016) The Value of History, Physical Examination, and Radiographic Findings in the Diagnosis of Symptomatic Meniscal Tear among Middle-Age Subjects with Knee Pain. Arthritis Care Res (Hoboken) :
Sparks, Jeffrey A; Chang, Shun-Chiao; Karlson, Elizabeth W (2016) Authors' reply to the letter "Mortality due to respiratory causes in rheumatoid arthritis should be interpreted in the context of 'ever' smoking and may be due to ILD". Arthritis Care Res (Hoboken) :

Showing the most recent 10 out of 404 publications