This proposal represents a competitive renewal of the Boston University Multidisciplinary Clinical Research Center grant which was established in 2001 and built on a strong foundation of outstanding epidemiology and clinical research. The strong record of accomplishment in patient oriented medical research at Boston University has been not only maintained in the last four years but expanded. What we propose creates new directions and areas of research for this already productive group of investigators who work together closely, and it promises to produce further major insights into rheumatic disease causation and treatment. Led by Director, Dr. David Felson and Associate Director, Dr. Saralynn Allaire, this group of full-time MCRC investigators who work together in shared office space will meet weekly in Methodology Core group meetings to discuss and review both projects proposed here and other funded and non-funded clinical research. This Core will provide support for the proposed projects: "Bracing in Patellofemoral Osteoarthritis: A Clinical Trial", David J. Hunter, PI, "Risk Factors for Gout Attacks: A Case-crossover Study", Yuqing Zhang, PI, "Interplay of Thrombosis and Inflammation in Vasculitis", Peter Merkel, PI. An administrative unit will provide oversight to ensure that these projects are successfully accomplished and that core resources for support of these and other projects are allocated efficiently.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
2P60AR047785-11
Application #
8289838
Study Section
Special Emphasis Panel (ZAR1-KM (M1))
Program Officer
Lester, Gayle E
Project Start
2001-09-24
Project End
2017-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
11
Fiscal Year
2012
Total Cost
$1,289,608
Indirect Cost
$496,128
Name
Boston University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
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White, Daniel K; Neogi, Tuhina; King, Wendy C et al. (2014) Can change in prolonged walking be inferred from a short test of gait speed among older adults who are initially well-functioning? Phys Ther 94:1285-93
Okada, Yukinori; Diogo, Dorothee; Greenberg, Jeffrey D et al. (2014) Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene. PLoS One 9:e87645
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