This proposal represents a competitive renewal of the Boston University Multidisciplinary Clinical Research Center grant which was established in 2001 and built on a strong foundation of outstanding epidemiology and clinical research. The strong record of accomplishment in patient oriented medical research at Boston University has been not only maintained in the last four years but expanded. What we propose creates new directions and areas of research for this already productive group of investigators who work together closely, and it promises to produce further major insights into rheumatic disease causation and treatment. Led by Director, Dr. David Felson and Associate Director, Dr. Saralynn Allaire, this group of full-time MCRC investigators who work together in shared office space will meet weekly in Methodology Core group meetings to discuss and review both projects proposed here and other funded and non-funded clinical research. This Core will provide support for the proposed projects: """"""""Bracing in Patellofemoral Osteoarthritis: A Clinical Trial"""""""", David J. Hunter, PI, """"""""Risk Factors for Gout Attacks: A Case-crossover Study"""""""", Yuqing Zhang, PI, """"""""Interplay of Thrombosis and Inflammation in Vasculitis"""""""", Peter Merkel, PI. An administrative unit will provide oversight to ensure that these projects are successfully accomplished and that core resources for support of these and other projects are allocated efficiently.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Comprehensive Center (P60)
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Application #
Study Section
Special Emphasis Panel (ZAR1-KM (M1))
Program Officer
Lester, Gayle E
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Boston University
Internal Medicine/Medicine
Schools of Medicine
United States
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White, Daniel K; Neogi, Tuhina; Zhang, Yuqing et al. (2017) Association of Slow Gait Speed With Trajectories of Worsening Depressive Symptoms in Knee Osteoarthritis: An Observational Study. Arthritis Care Res (Hoboken) 69:209-215
Zhang, Yuqing; Lu, Na; Peloquin, Christine et al. (2017) Improved survival in rheumatoid arthritis: a general population-based cohort study. Ann Rheum Dis 76:408-413
Vargas-Santos, Ana Beatriz; Neogi, Tuhina (2017) Management of Gout and Hyperuricemia in CKD. Am J Kidney Dis 70:422-439
Widjajahakim, Rafael; Roux, Michael; Jarraya, Mohamed et al. (2017) Relationship of Trochlear Morphology and Patellofemoral Joint Alignment to Superolateral Hoffa Fat Pad Edema on MR Images in Individuals with or at Risk for Osteoarthritis of the Knee: The MOST Study. Radiology 284:806-814
Unizony, Sebastian; Lu, Na; Tomasson, Gunnar et al. (2017) Temporal Trends of Venous Thromboembolism Risk Before and After Diagnosis of Giant Cell Arteritis. Arthritis Rheumatol 69:176-184
Culvenor, Adam G; Felson, David T; Niu, Jingbo et al. (2017) Thigh Muscle Specific-Strength and the Risk of Incident Knee Osteoarthritis: The Influence of Sex and Greater Body Mass Index. Arthritis Care Res (Hoboken) 69:1266-1270
Misra, Devyani; Lu, Na; Felson, David et al. (2017) Does knee replacement surgery for osteoarthritis improve survival? The jury is still out. Ann Rheum Dis 76:140-146
Misra, Devyani; Peloquin, Christine; Kiel, Douglas P et al. (2017) Intermittent Nitrate Use and Risk of Hip Fracture. Am J Med 130:229.e15-229.e20
Vaughan, Molly W; Felson, David T; LaValley, Michael P et al. (2017) Perceived Community Environmental Factors and Risk of Five-Year Participation Restriction Among Older Adults With or at Risk of Knee Osteoarthritis. Arthritis Care Res (Hoboken) 69:952-958
Strand, Mette P; Neogi, Tuhina; Niu, Jingbo et al. (2017) No association between metabolic syndrome and radiographic hand osteoarthritis: Data from the Framingham study. Arthritis Care Res (Hoboken) :

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