The Specific Aims of the Vanderbilt University Multidisciplinary Clinical Research Center (VMCRC) are: 1) To pursue a multidisciplinary clinical research scientific program that will alter the outcomes of patients with rheumatic diseases. 2) To promote and foster multidisciplinary clinical research in rheumatic diseases by leveraging institutional training and research resources and the extensive research base that supports the VMCRC and facilitate growth of new projects and the training of new investigators. The VMCRC (Director: C. Michael Stein MD;Associate Director: Wayne Ray PhD) is comprised of three clinical research projects centered around a Methodology Core that serves all projects. The three projects span a range of clinical research approaches (CRC clinical research, pharmacoepidemiology, health outcomes) and diverse rheumatic diseases (rheumatoid arthritis, lupus, osteoarthritis) central to the mission of NIAMS. Project 1 (Stein) is a clinical research/CRC proof-of-concept study using pioglitazone to define the relationships between hyperinsulinemia, disease activity and inflammation in patients with rheumatoid arthritis. Project 2 (Griffin) studies the effect of newer disease modifying anti-rheumatic drugs on the long-term outcomes of cardiovascular disease, diabetes, infection and lymphoma. Project 3 (Cooper) uses a unique local pharmaco-epidemiologic resources to address the risks of anti-rheumatic drugs administered during pregnancy. A common Methodology Core (Arbogast) provides support for the design, collection and analysis of data, and the development of new techniques for improvement of the research methodology used. An Executive Committee and an External Advisory Committee will assist in scientific direction, strategic planning and the leveraging of VMCRC and institutional resources to greatest effect. An Administrative Unit will ensure responsible, efficient conduct of research, seamless communication, fiscal efficiency and thoughtful prioritization of resources. In summary, the VMCRC brings together talented multidisciplinary clinical researchers with a track record in performing collaborative research, fostering new research and facilitating the growth of trainees. The VMCRC is situated in an environment that provides an extraordinarily rich research base as well as outstanding institutional resources and a commitment to clinical research that will facilitate success of the Center.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Comprehensive Center (P60)
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Special Emphasis Panel (ZAR1-CHW-G (J2))
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Witter, James
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Vanderbilt University Medical Center
Internal Medicine/Medicine
Schools of Medicine
United States
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Kawai, Vivian K; Chung, Cecilia P; Solus, Joseph F et al. (2015) The ability of the 2013 American College of Cardiology/American Heart Association cardiovascular risk score to identify rheumatoid arthritis patients with high coronary artery calcification scores. Arthritis Rheumatol 67:381-5
Hung, Adriana M; Limkunakul, Chutatip; Placido, Jenny S et al. (2014) Administration of IL-1ra improves adiponectin levels in chronic hemodialysis patients. J Nephrol :
Kawai, Vivian K; Avalos, Ingrid; Oeser, Annette et al. (2014) Suboptimal inhibition of platelet cyclooxygenase 1 by aspirin in systemic lupus erythematosus: association with metabolic syndrome. Arthritis Care Res (Hoboken) 66:285-92
Baddley, John W; Winthrop, Kevin L; Chen, Lang et al. (2014) Non-viral opportunistic infections in new users of tumour necrosis factor inhibitor therapy: results of the SAfety Assessment of Biologic ThERapy (SABER) study. Ann Rheum Dis 73:1942-8
Ormseth, Michelle J; Stein, C Michael (2014) Is visceral fat the missing link in the relationship between inflammation and insulin resistance in RA? J Rheumatol 41:1906-9
Cooper, William O; Cheetham, T Craig; Li, De-Kun et al. (2014) Brief report: Risk of adverse fetal outcomes associated with immunosuppressive medications for chronic immune-mediated diseases in pregnancy. Arthritis Rheumatol 66:444-50
Ormseth, Michelle J; Oeser, Annette M; Cunningham, Andrew et al. (2014) Reversing vascular dysfunction in rheumatoid arthritis: improved augmentation index but not endothelial function with peroxisome proliferator-activated receptor ? agonist therapy. Arthritis Rheumatol 66:2331-8
Chung, C P; Solus, J F; Oeser, A et al. (2014) Genetic variation and coronary atherosclerosis in patients with systemic lupus erythematosus. Lupus 23:876-80
Bradham, William S; Ormseth, Michelle J; Oeser, Annette et al. (2014) Insulin resistance is associated with increased concentrations of NT-proBNP in rheumatoid arthritis: IL-6 as a potential mediator. Inflammation 37:801-8
Chung, Cecilia P; Schmidt, Dennis; Stein, Charles Michael et al. (2013) Increased oxidative stress in patients with depression and its relationship to treatment. Psychiatry Res 206:213-6

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