The Multidisciplinary Clinical Research Center (MCRC) in Musculoskeletal Diseases at Dartmouth is committed to promoting rigorous clinical research through focused research collaborations and cross-disciplinary educational initiatives among diverse disciplines. These disciplines include orthopedic surgery, medicine, geriatrics, biostatistics, health services research, decision sciences, health economics, informatics and epidemiology, which all are critical for meeting the MCRC's objective of improving the health care quality and health for patients suffering from musculoskeletal diseases. The growth in infrastructure and methodological expertise associated with the NIAMS-sponsored Spine Patient Outcomes Research Trial (SPORT) has combined with large institutional investments in comparative effectiveness research to make this an opportune time to further develop the MCRC at Dartmouth. Based on a well-developed Methodology Core leveraging and complementing new institutional resources, an expanded research base will be provided with comprehensive methodological and administrative support. Three integral projects are planned within the MCRC: Project 1 will conduct comparative effectiveness research focused on secondary fracture prevention in a nationally-representative population of elders who have sustained a hip or other osteoporosis-related fracture. Project 2 will develop, validate, and evaluate a novel web-based treatment outcomes calculator for communicating individualized risk and benefit information to aid surgeons, primary care physicians and patients facing complex decisions related to surgery for back-pain related conditions. Project 3 (developmental) will explore the validity of claims-based methods to ascertain complications of surgery and develop a novel claims-based approach to safety surveillance using the biological agent Bone Morphogenetic Protein (BMP) as a case study. Through the Methodology Core, new educational opportunities will be provided for clinicians and researchers in training, thereby fostering new clinical research initiatives that will further improve the health of patients with musculoskeletal disease.

Public Health Relevance

Dartmouth has many experienced investigators and sources of data that will be used to improve health for individuals with musculoskeletal disease. By expanding a unique national research program in musculoskeletal diseases, this grant will train new researchers and provide high-quality resources for research projects addressing health care in those who have broken a bone, decision making about back surgery, and the safety of new medical devices.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
5P60AR062799-02
Application #
8500218
Study Section
Special Emphasis Panel (ZAR1-KM (M1))
Program Officer
Panagis, James S
Project Start
2012-09-01
Project End
2017-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
2
Fiscal Year
2013
Total Cost
$1,194,805
Indirect Cost
$434,722
Name
Dartmouth College
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Prohaska, Matthew G; Keeney, Benjamin J; Beg, Haaris A et al. (2017) Preoperative body mass index and physical function are associated with length of stay and facility discharge after total knee arthroplasty. Knee 24:634-640
Keeney, Benjamin J; Koenig, Karl M; Paddock, Nicholas G et al. (2017) Do Aggregate Socioeconomic Status Factors Predict Outcomes for Total Knee Arthroplasty in a Rural Population? J Arthroplasty 32:3583-3590
Massaro, Joseph M; Murabito, Joanne M; Au, Rhoda et al. (2017) Evidence on the Validity of a Comprehensive Health Risk Index and Implications for Ambulatory Care and Population Health Management. J Ambul Care Manage 40:297-304
Mata-Fink, Ana; Philipson, Daniel J; Keeney, Benjamin J et al. (2017) Patient-Reported Outcomes After Revision of Metal-on-Metal Total Bearings in Total Hip Arthroplasty. J Arthroplasty 32:1241-1244
Molloy, Ilda B; Martin, Brook I; Moschetti, Wayne E et al. (2017) Effects of the Length of Stay on the Cost of Total Knee and Total Hip Arthroplasty from 2002 to 2013. J Bone Joint Surg Am 99:402-407
Lurie, Jon D; Tosteson, Tor D; Tosteson, Anna A N et al. (2017) TO THE EDITOR. Spine (Phila Pa 1976) 42:E1214
Gerling, Michael C; Leven, Dante; Passias, Peter G et al. (2017) Risk Factors for Reoperation in Patients Treated Surgically for Degenerative Spondylolisthesis: A Subanalysis of the 8-year Data From the SPORT Trial. Spine (Phila Pa 1976) 42:1559-1569
Marfeo, Elizabeth E; Ni, Pengsheng; McDonough, Christine et al. (2017) Improving Assessment of Work Related Mental Health Function Using the Work Disability Functional Assessment Battery (WD-FAB). J Occup Rehabil :
Lin, Timothy J; Bendich, Ilya; Ha, Alex S et al. (2017) A Comparison of Radiographic Outcomes After Total Hip Arthroplasty Between the Posterior Approach and Direct Anterior Approach With Intraoperative Fluoroscopy. J Arthroplasty 32:616-623
Skolasky, Richard L; Scherer, Emily A; Wegener, Stephen T et al. (2017) Does reduction in sciatica symptoms precede improvement in disability and physical health among those treated surgically for intervertebral disc herniation? Analysis of temporal patterns in data from the Spine Patient Outcomes Research Trial. Spine J :

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