The Multidisciplinary Clinical Research Center (MCRC) in Musculoskeletal Diseases at Dartmouth is committed to promoting rigorous clinical research through focused research collaborations and cross-disciplinary educational initiatives among diverse disciplines. These disciplines include orthopedic surgery, medicine, geriatrics, biostatistics, health services research, decision sciences, health economics, informatics and epidemiology, which all are critical for meeting the MCRC's objective of improving the health care quality and health for patients suffering from musculoskeletal diseases. The growth in infrastructure and methodological expertise associated with the NIAMS-sponsored Spine Patient Outcomes Research Trial (SPORT) has combined with large institutional investments in comparative effectiveness research to make this an opportune time to further develop the MCRC at Dartmouth. Based on a well-developed Methodology Core leveraging and complementing new institutional resources, an expanded research base will be provided with comprehensive methodological and administrative support. Three integral projects are planned within the MCRC: Project 1 will conduct comparative effectiveness research focused on secondary fracture prevention in a nationally-representative population of elders who have sustained a hip or other osteoporosis-related fracture. Project 2 will develop, validate, and evaluate a novel web-based treatment outcomes calculator for communicating individualized risk and benefit information to aid surgeons, primary care physicians and patients facing complex decisions related to surgery for back-pain related conditions. Project 3 (developmental) will explore the validity of claims-based methods to ascertain complications of surgery and develop a novel claims-based approach to safety surveillance using the biological agent Bone Morphogenetic Protein (BMP) as a case study. Through the Methodology Core, new educational opportunities will be provided for clinicians and researchers in training, thereby fostering new clinical research initiatives that will further improve the health of patients with musculoskeletal disease.

Public Health Relevance

Dartmouth has many experienced investigators and sources of data that will be used to improve health for individuals with musculoskeletal disease. By expanding a unique national research program in musculoskeletal diseases, this grant will train new researchers and provide high-quality resources for research projects addressing health care in those who have broken a bone, decision making about back surgery, and the safety of new medical devices.

National Institute of Health (NIH)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZAR1)
Program Officer
Panagis, James S
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Dartmouth College
Public Health & Prev Medicine
Schools of Medicine
United States
Zip Code
Akkineni, Roopa; Tapp, Stephanie; Tosteson, Anna N A et al. (2014) Treatment of asymptomatic hyperuricemia and prevention of vascular disease: a decision analytic approach. J Rheumatol 41:739-48
Martin, Brook I; Franklin, Gary M; Deyo, Richard A et al. (2014) How do coverage policies influence practice patterns, safety, and cost of initial lumbar fusion surgery? A population-based comparison of workers' compensation systems. Spine J 14:1237-46
Martin, Brook I; Lurie, Jon D; Tosteson, Anna N A et al. (2014) Indications for spine surgery: validation of an administrative coding algorithm to classify degenerative diagnoses. Spine (Phila Pa 1976) 39:769-79
Weinstein, James N; Tosteson, Anna N A; Tosteson, Tor D et al. (2014) The SPORT value compass: do the extra costs of undergoing spine surgery produce better health benefits? Med Care 52:1055-63
Liu, Stephen K; Munson, Jeffrey C; Bell, John-Erik et al. (2014) Response letter to Herbert L. Muncie, Jr. J Am Geriatr Soc 62:998-9
Lurie, Jon D; Tosteson, Tor D; Tosteson, Anna N A et al. (2014) Surgical versus nonoperative treatment for lumbar disc herniation: eight-year results for the spine patient outcomes research trial. Spine (Phila Pa 1976) 39:3-16
Resnick, Daniel K; Tosteson, Anna N A; Groman, Rachel F et al. (2014) Setting the equation: establishing value in spine care. Spine (Phila Pa 1976) 39:S43-50
McGuire, Kevin J; Khaleel, Mohammed A; Rihn, Jeffrey A et al. (2014) The effect of high obesity on outcomes of treatment for lumbar spinal conditions: subgroup analysis of the spine patient outcomes research trial. Spine (Phila Pa 1976) 39:1975-80
Liu, Stephen K; Munson, Jeffrey C; Bell, John-Erik et al. (2013) Quality of osteoporosis care of older Medicare recipients with fragility fractures: 2006 to 2010. J Am Geriatr Soc 61:1855-62
Lurie, Jon D; Moses, Rachel A; Tosteson, Anna N A et al. (2013) Magnetic resonance imaging predictors of surgical outcome in patients with lumbar intervertebral disc herniation. Spine (Phila Pa 1976) 38:1216-25

Showing the most recent 10 out of 11 publications