The Multidisciplinary Clinical Research Center (MCRC) in Musculoskeletal Diseases at Dartmouth is committed to promoting rigorous clinical research through focused research collaborations and cross-disciplinary educational initiatives among diverse disciplines. These disciplines include orthopedic surgery, medicine, geriatrics, biostatistics, health services research, decision sciences, health economics, informatics and epidemiology, which all are critical for meeting the MCRC's objective of improving the health care quality and health for patients suffering from musculoskeletal diseases. The growth in infrastructure and methodological expertise associated with the NIAMS-sponsored Spine Patient Outcomes Research Trial (SPORT) has combined with large institutional investments in comparative effectiveness research to make this an opportune time to further develop the MCRC at Dartmouth. Based on a well-developed Methodology Core leveraging and complementing new institutional resources, an expanded research base will be provided with comprehensive methodological and administrative support. Three integral projects are planned within the MCRC: Project 1 will conduct comparative effectiveness research focused on secondary fracture prevention in a nationally-representative population of elders who have sustained a hip or other osteoporosis-related fracture. Project 2 will develop, validate, and evaluate a novel web-based treatment outcomes calculator for communicating individualized risk and benefit information to aid surgeons, primary care physicians and patients facing complex decisions related to surgery for back-pain related conditions. Project 3 (developmental) will explore the validity of claims-based methods to ascertain complications of surgery and develop a novel claims-based approach to safety surveillance using the biological agent Bone Morphogenetic Protein (BMP) as a case study. Through the Methodology Core, new educational opportunities will be provided for clinicians and researchers in training, thereby fostering new clinical research initiatives that will further improve the health of patients with musculoskeletal disease.

Public Health Relevance

Dartmouth has many experienced investigators and sources of data that will be used to improve health for individuals with musculoskeletal disease. By expanding a unique national research program in musculoskeletal diseases, this grant will train new researchers and provide high-quality resources for research projects addressing health care in those who have broken a bone, decision making about back surgery, and the safety of new medical devices.

Agency
National Institute of Health (NIH)
Type
Comprehensive Center (P60)
Project #
5P60AR062799-03
Application #
8712124
Study Section
Special Emphasis Panel (ZAR1)
Program Officer
Panagis, James S
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
City
Hanover
State
NH
Country
United States
Zip Code
03755
Gerling, Michael C; Leven, Dante; Passias, Peter G et al. (2016) Risk Factors for Reoperation in Patients Treated Surgically for Lumbar Stenosis: A Subanalysis of the 8-year Data From the SPORT Trial. Spine (Phila Pa 1976) 41:901-9
Lurie, Jon; Tomkins-Lane, Christy (2016) Management of lumbar spinal stenosis. BMJ 352:h6234
Barlow, Daniel R; Higgins, Brendan T; Ozanne, Elissa M et al. (2016) Cost Effectiveness of Operative Versus Non-Operative Treatment of Geriatric Type-II Odontoid Fracture. Spine (Phila Pa 1976) 41:610-7
Mirza, Sohail K (2016) Surgery and physical therapy likely yield similar outcomes in spinal stenosis. Evid Based Med 21:31
Kearing, Stephen; Berg, Susan Z; Lurie, Jon D (2016) Can Decision Support Help Patients With Spinal Stenosis Make a Treatment Choice?: A Prospective Study Assessing the Impact of a Patient Decision Aid and Health Coaching. Spine (Phila Pa 1976) 41:563-7
Bynum, J P W; Bell, J-E; Cantu, R V et al. (2016) Second fractures among older adults in the year following hip, shoulder, or wrist fracture. Osteoporos Int 27:2207-15
Suri, Pradeep; Pearson, Adam M; Zhao, Wenyan et al. (2016) Pain Recurrence after Discectomy for Symptomatic Lumbar Disc Herniation. Spine (Phila Pa 1976) :
Lurie, Jon D; Henderson, Eric R; McDonough, Christine M et al. (2016) Effect of Expectations on Treatment Outcome for Lumbar Intervertebral Disc Herniation. Spine (Phila Pa 1976) 41:803-9
Martin, Brook I; Deyo, Richard A; Lurie, Jon D et al. (2016) Effects of a Commercial Insurance Policy Restriction on Lumbar Fusion in North Carolina and the Implications for National Adoption. Spine (Phila Pa 1976) 41:647-55
Lin, Timothy J; Bendich, Ilya; Ha, Alex S et al. (2016) A Comparison of Radiographic Outcomes After Total Hip Arthroplasty Between the Posterior Approach and Direct Anterior Approach With Intraoperative Fluoroscopy. J Arthroplasty :

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