This application is to continue Albert Einstein College of Medicine's Diabetes Research and Training Center (DRTC) in order to support the discovery, application and translation of scientific knowledge for the treatment and cure of diabetes. The Einstein DRTC serves as a nexus to i) enhance diabetes research, education and training;ii) to attract, mentor and retain research investigators;iii) provide state-of-the-art Core services to maximize research productivity;iv) foster interdisciplinary collaborations, and v) to promote the translation of scientific findings from the bench to bedside and community, especially in underserved and minority populations. To accomplish these goals, we are requesting support for an administrative component with overall responsibility for management, integration and promotion of research and training. This component will supervise the Research Base, Biomedical and Prevention &Control Cores, the Enrichment and Pilot &Feasibility Study Programs. Since the previous application, the Einstein DRTC, through new leadership and Institutional commitment, has expanded the faculty Research Base, expanded and developed new Core functions and enhanced the Enrichment and Pilot &Feasibility Programs. In particular, over the past 16 months we have recruited 10 new Einstein DRTC faculty, appointed 4 existing senior Einstein faculty as members of the DRTC, based upon their new diabetes research focus, and provided full Einstein DRTC faculty membership to 8 faculty at other New York institutions as well as to the members of the Columbia DERC. Four new cutting-edge Biomedical Cores that complement and add to the services already provided by two existing Einstein DRTC cores and the other Institutional cores. The DRTC Biomedical Cores include, 1) Animal Physiology;2) Stable Isotope &Metabolomics;3) Hormone Assay;4) Analytical Imaging;5) Flow Cytometry;and 6) Epigenomics. The Prevention and Control (P&C) component has also expanded its research base of behavioral, health services, and epidemiological faculty and has established three functional units that include 1) Clinical Research Methodology;2) Behavioral Intervention/Evaluation Methodology and 3) Social-Environment Research Methodology. We have continued our outstanding Pilot &Feasibility Study Program through which new initiatives in basic, clinical, and behavioral research are supported. The Einstein DRTC Enrichment program has continued to host outstanding speakers, to videoconference and co-host seminars with Mount Sinai Medical School, to have weekly trainee Diabetes Workshop presentations and to provide Core educational workshops and training venues.
Diabetes and related metabolic disorders are rapidly increasing and have major impacts on quality of life, lifespan responsible for a large portion of our health care cost burden. The goals of this project are to provide resources for molecular, cellular, tissue, organismal, pre-clinical, clinical and translation research to improve and deliver diabetes treatment.
|Babad, Jeffrey; Ali, Riyasat; Schloss, Jennifer et al. (2016) An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients. J Diabetes Res 2016:7959060|
|Commissariat, Persis V; Kenowitz, Joslyn R; Trast, Jeniece et al. (2016) Developing a Personal and Social Identity With Type 1 Diabetes During Adolescence: A Hypothesis Generative Study. Qual Health Res 26:672-84|
|Mera, Paula; Laue, Kathrin; Ferron, Mathieu et al. (2016) Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise. Cell Metab 23:1078-92|
|Ali, Riyasat; Babad, Jeffrey; Follenzi, Antonia et al. (2016) Genetically modified human CD4(+) T cells can be evaluated inÂ vivo without lethal graft-versus-host disease. Immunology 148:339-51|
|Edison, Arthur S; Hall, Robert D; Junot, Christophe et al. (2016) The Time Is Right to Focus on Model Organism Metabolomes. Metabolites 6:|
|Chen, Wei; Melamed, Michal L; Hostetter, Thomas H et al. (2016) Effect of oral sodium bicarbonate on fibroblast growth factor-23 in patients with chronic kidney disease: a pilot study. BMC Nephrol 17:114|
|Gonzalez, Jeffrey S; Kane, Naomi S; Binko, Deborah H et al. (2016) Tangled Up in Blue: Unraveling the Links Between Emotional Distress and Treatment Adherence in Type 2 Diabetes. Diabetes Care 39:2182-2189|
|Roshandel, Delnaz; Klein, Ronald; Klein, Barbara E K et al. (2016) New Locus for Skin Intrinsic Fluorescence in Type 1 Diabetes Also Associated With Blood and Skin Glycated Proteins. Diabetes 65:2060-71|
|Nie, Wenna; Yan, Leyu; Lee, Yie H et al. (2016) Advanced mass spectrometry-based multi-omics technologies for exploring the pathogenesis of hepatocellular carcinoma. Mass Spectrom Rev 35:331-49|
|Yeh, M-C; Heo, M; Suchday, S et al. (2016) Translation of the Diabetes Prevention Program for diabetes risk reduction in Chinese immigrants in New York City. Diabet Med 33:547-51|
Showing the most recent 10 out of 531 publications