The Michigan Diabetes Research and Training Center (MDRTC) is a multidisciplinary unit of The University of Michigan Health System. The MDRTC is now in its thirtieth year, having been funded by the NIH/NIDDK since 1977. This application is for a seventh five-year continuation of funding for the period February 1, 2008 through January 31, 2013. The Center exists to meet the needs of investigators and thereby support and strengthen the University's interdepartmental activities in research, training and outreach in the field of diabetes, its complications and related endocrine and metabolic disorders. The resources provided by the MDRTC have expanded and enriched the base of investigators involved in diabetes research, the Center's most important resource, and have facilitated innovative multidisciplinary biomedical and translational research programs. The overall goals of the MDRTC are to: 1. Facilitate and focus basic molecular and cellular research in the areas of diabetes, its complications and related endocrine and metabolic disorders. 2. Promote the application of relevant new knowledge to innovative, relevant, feasible, and cost-effective approaches to the prevention and control of diabetes and its complications through behavioral, clinical, epidemiologic, and health services research. 3. Evaluate, refine and disseminate new knowledge regarding diabetes, its complications, and related disorders into sustainable, widespread community practice, especially in communities at increased risk. 4. Recruit, train, motivate and retain an effective workforce of basic, clinical, epidemiologic, and health services investigators and health care providers in the areas of diabetes, endocrinology and metabolism.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Comprehensive Center (P60)
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Study Section
Special Emphasis Panel (ZDK1-GRB-S (O1))
Program Officer
Hyde, James F
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University of Michigan Ann Arbor
Internal Medicine/Medicine
Schools of Medicine
Ann Arbor
United States
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Kyono, Yasuhiro; Subramani, Arasakumar; Ramadoss, Preeti et al. (2016) Liganded Thyroid Hormone Receptors Transactivate the DNA Methyltransferase 3a Gene in Mouse Neuronal Cells. Endocrinology 157:3647-57
Meek, Thomas H; Nelson, Jarrell T; Matsen, Miles E et al. (2016) Functional identification of a neurocircuit regulating blood glucose. Proc Natl Acad Sci U S A 113:E2073-82
Glynn, Eric; Thompson, Benjamin; Vadrevu, Suryakiran et al. (2016) Chronic Glucose Exposure Systematically Shifts the Oscillatory Threshold of Mouse Islets: Experimental Evidence for an Early Intrinsic Mechanism of Compensation for Hyperglycemia. Endocrinology 157:611-23
Wood, Jamie R; Connor, Crystal G; Cheng, Peiyao et al. (2016) Vitamin D status in youth with type 1 and type 2 diabetes enrolled in the Pediatric Diabetes Consortium (PDC) is not worse than in youth without diabetes. Pediatr Diabetes 17:584-591
Sims-Robinson, Catrina; Bakeman, Anna; Rosko, Andrew et al. (2016) The Role of Oxidized Cholesterol in Diabetes-Induced Lysosomal Dysfunction in the Brain. Mol Neurobiol 53:2287-96
Liu, Xuwen; Dreffs, Alyssa; Díaz-Coránguez, Monica et al. (2016) Occludin S490 Phosphorylation Regulates Vascular Endothelial Growth Factor-Induced Retinal Neovascularization. Am J Pathol 186:2486-99
Blandino-Rosano, Manuel; Scheys, Joshua O; Jimenez-Palomares, Margarita et al. (2016) 4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass. Diabetes 65:2235-48
Yavari, Arash; Stocker, Claire J; Ghaffari, Sahar et al. (2016) Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Cell Metab 23:821-36
Asao, K; Rothberg, A E; Arcori, L et al. (2016) Sweet taste preferences before and after an intensive medical weight loss intervention. Obes Sci Pract 2:189-195
Zhu, Shuaishuai; Larkin, Dennis; Lu, Shusheng et al. (2016) Monitoring C-Peptide Storage and Secretion in Islet β-Cells In Vitro and In Vivo. Diabetes 65:699-709

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