Abstract

The Animal Resource Subcore provides investigators access to a number of animal models that can be used to study diabetes and related metabolic disorders. The subcore provides space, equipment and personnel for surgical and experimental assistance as well as animal care. Investigators pay for use of the surgical suites, animal purchase and board, and for experimental supplies. Conscious dog models available include those that allow assessment of organ (liver, gut, kidney, limb, pancreas) balance and those that permit selective tissue (brain, pancreas, liver) perfusion. In addition, adrenalectomized and depancreatized dogs are available, as are dogs in which nerve cooling can be carried out using previously inserted cooling coils. Experimental techniques available include glucose and hormone clamping, as well as """"""""on-line"""""""" monitoring of blood pressure and blood flow. Users identified with this subcore project as increased demand for all services offered in the upcoming project year.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Comprehensive Center (P60)
Project #
5P60DK020593-23
Application #
6414869
Study Section
Project Start
2000-12-01
Project End
2002-03-31
Budget Start
Budget End
Support Year
23
Fiscal Year
2001
Total Cost
$211,312
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Horwitz, Elad; Krogvold, Lars; Zhitomirsky, Sophia et al. (2018) ?-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes. Diabetes 67:2305-2318
Lu, Sichang; McGough, Madison A P; Shiels, Stefanie M et al. (2018) Settable polymer/ceramic composite bone grafts stabilize weight-bearing tibial plateau slot defects and integrate with host bone in an ovine model. Biomaterials 179:29-45
Hull, P C; Buchowski, M; Canedo, J R et al. (2018) Childhood obesity prevention cluster randomized trial for Hispanic families: outcomes of the healthy families study. Pediatr Obes 13:686-696
Kook, Seunghyi; Qi, Aidong; Wang, Ping et al. (2018) Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak Syndromes. Am J Respir Cell Mol Biol 58:566-574
Wang, Feng; Katagiri, Daisuke; Li, Ke et al. (2018) Assessment of renal fibrosis in murine diabetic nephropathy using quantitative magnetization transfer MRI. Magn Reson Med 80:2655-2669
Harris, Nicholas A; Isaac, Austin T; Günther, Anne et al. (2018) Dorsal BNST ?2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. J Neurosci 38:8922-8942
Santos Guasch, Gabriela L; Beeler, J Scott; Marshall, Clayton B et al. (2018) p73 Is Required for Ovarian Follicle Development and Regulates a Gene Network Involved in Cell-to-Cell Adhesion. iScience 8:236-249
Vierra, Nicholas C; Dickerson, Matthew T; Jordan, Kelli L et al. (2018) TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion. Mol Metab 9:84-97
Kovtun, Oleg; Tomlinson, Ian D; Bailey, Danielle M et al. (2018) Single Quantum Dot Tracking Illuminates Neuroscience at the Nanoscale. Chem Phys Lett 706:741-752
Rossi, Mario; Zhu, Lu; McMillin, Sara M et al. (2018) Hepatic Gi signaling regulates whole-body glucose homeostasis. J Clin Invest 128:746-759

Showing the most recent 10 out of 1487 publications