The Pilot and Feasibility (P&F) program has funded 85 projects (including 2006) since it inception in 1978.This program has been extremely valuable and effective by providing funds for the support of diabetesrelatedprojects. The goal of the program is to support small research projects by new investigators (whohave little or no independent research support) or established investigators who are turning to diabetesresearch for the first time. The vast majority of the proposals are in the former category. Three new projectsare normally initiated each year. After a university-wide solicitation of proposals, four individuals (twointernal and two external to the institution) review each grant. The critiques of the proposal are evaluated bythe P&F Review Committee (equivalent to an NIH study section), and each proposal is assigned a priorityscore. The proposals and priority scores are then presented to the DRTC Executive Committee (equivalentto the NIH Council) for a funding decision. Support for a second year of research is awarded whensatisfactory work is completed in year one and if support for the projects has not been obtained in theinterim.The success rate of this program, measured either by the number of investigators who remain involved indiabetes research, or who convert their P&F into a nationally awarded, peer-reviewed grant, is high (75% ofgrants funded from 1996-2000). In addition, this program funds applications from a wide variety ofdepartments within the institution. For example, faculty members from Departments of Medicine, MolecularPhysiology and Biophysics, Biochemistry, Biomedical Engineering, Anesthesia, Pediatrics, Cell andDevelopmental Biology, Chemistry, Nursing, and Pathology were funded over the past five years. The P&Fprogram also provides visibility for the DRTC within the Vanderbilt scientific community and thus makes thescientific community more aware of the DRTC, its research efforts, and its core facilities. The importanceand effectiveness of the DRTC P&F program is underscored by the decision of the VUMC leadership toprovide additional funds ($100K) for this program in the next funding cycle.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Comprehensive Center (P60)
Project #
5P60DK020593-30
Application #
7627221
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
30
Fiscal Year
2008
Total Cost
$535,409
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Yao, Lina; Seaton, Sarah Craven; Ndousse-Fetter, Sula et al. (2018) A selective gut bacterial bile salt hydrolase alters host metabolism. Elife 7:
Mani, Bharath K; Castorena, Carlos M; Osborne-Lawrence, Sherri et al. (2018) Ghrelin mediates exercise endurance and the feeding response post-exercise. Mol Metab 9:114-130
Bolus, W Reid; Peterson, Kristin R; Hubler, Merla J et al. (2018) Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments. Mol Metab 8:86-95
West, Kathryn L; Kelm, Nathaniel D; Carson, Robert P et al. (2018) Myelin volume fraction imaging with MRI. Neuroimage 182:511-521
Barke, Theresa L; Goldstein, Jeffery A; Sundermann, Alexandra C et al. (2018) Gestational diabetes mellitus is associated with increased CD163 expression and iron storage in the placenta. Am J Reprod Immunol 80:e13020
Rohrbough, Jeffrey; Nguyen, Hong-Ngan; Lamb, Fred S (2018) Modulation of ClC-3 gating and proton/anion exchange by internal and external protons and the anion selectivity filter. J Physiol 596:4091-4119
Schlegel, Cameron; Lapierre, Lynne A; Weis, Victoria G et al. (2018) Reversible deficits in apical transporter trafficking associated with deficiency in diacylglycerol acyltransferase. Traffic 19:879-892
Moore, Mary Courtney; Smith, Marta S; Farmer, Ben et al. (2018) Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day. Diabetes 67:1237-1245
Cooke, Allison L; Morris, Jamie; Melchior, John T et al. (2018) A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL. J Lipid Res 59:1244-1255
Moore, Mary Courtney; Kelley, David E; Camacho, Raul C et al. (2018) Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts. Diabetes 67:1173-1181

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