Chronic diseases are on the rise among racial and ethnic minority youth and young adults. Prevalence disparities related to race/ethnicity and socioeconomic status persist or are widening(1). The concentration of risk factors and early onset conditions in young people are beginning to manifest as profoundly disturbing disparities in the rates of complications of chronic disease (stroke, amputation, kidney failure, heart failure,etc.) among middle-aged people. In addition, there is growing evidence that higher rates of chronic disease risk factors among mothers, such as obesity and glucose intolerance/pre-diabetes, may lead to "biologic programming" in utero, resulting in higher risks of chronic diseases in the next generation. This socioepidemiologic phenomenon has significant implications for the current and future physical, social, and emotional health of the affected populations. It affects their economic productivity, and the well-being of their families and communities. It also thwarts efforts to break negative life-course trajectories that relate disadvantage and discrimination to poor health.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Comprehensive Center (P60)
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Special Emphasis Panel (ZMD1-RN)
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University of California San Francisco
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Pino-Yanes, Maria; Thakur, Neeta; Gignoux, Christopher R et al. (2015) Genetic ancestry influences asthma susceptibility and lung function among Latinos. J Allergy Clin Immunol 135:228-35
Pino-Yanes, Maria; Gignoux, Christopher R; Galanter, Joshua M et al. (2015) Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos. J Allergy Clin Immunol 135:1502-10
Drake, Katherine A; Torgerson, Dara G; Gignoux, Christopher R et al. (2014) A genome-wide association study of bronchodilator response in Latinos implicates rare variants. J Allergy Clin Immunol 133:370-8
Royce, S; Khann, S; Yadav, R P et al. (2014) Identifying multidrug resistance in previously treated tuberculosis patients: a mixed-methods study in Cambodia. Int J Tuberc Lung Dis 18:1299-306
Szpiech, Zachary A; Hernandez, Ryan D (2014) selscan: an efficient multithreaded program to perform EHH-based scans for positive selection. Mol Biol Evol 31:2824-7
Rogers, Elizabeth A; Fine, Sarah; Handley, Margaret A et al. (2014) Development and early implementation of the bigger picture, a youth-targeted public health literacy campaign to prevent type 2 diabetes. J Health Commun 19 Suppl 2:144-60
Santos, Maricel G; Handley, Margaret A; Omark, Karin et al. (2014) ESL participation as a mechanism for advancing health literacy in immigrant communities. J Health Commun 19 Suppl 2:89-105
Myers, Rachel A; Scott, Nicole M; Gauderman, W James et al. (2014) Genome-wide interaction studies reveal sex-specific asthma risk alleles. Hum Mol Genet 23:5251-9
Poole, Alex; Urbanek, Cydney; Eng, Celeste et al. (2014) Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease. J Allergy Clin Immunol 133:670-8.e12
Galanter, Joshua M; Gignoux, Christopher R; Torgerson, Dara G et al. (2014) Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study. J Allergy Clin Immunol 134:295-305

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