The goal of this research project is to develop new, ultra-fast methods for dynamic imaging applications to enable greater clinical utility in the future. We intend to meet this goal by combining several existing image reconstruction methods, namely parallel imaging and non-Cartesian trajectories, to generate novel fast acquisition methods. Our current research involves the use of radial trajectories, as opposed to the standard, rectilinear trajectory, to acquire highly accelerated datasets in a very short time. These data can then be reconstructed using a special formulation of a parallel imaging method known as GRAPPA in order to reconstruct error-free images. Using this technique, we have acquired images with a temporal resolution of 60ms. We plan to expand this concept to trajectories which have the potential for even fast data acquisition, namely spiral and anisotropic field-of-view trajectories. Using these methods, we believe that it will be possible to generate images in less than 40ms, which will allow the acquisition real-time, free-breathing cardiac images, making EKG gating and breathholding unnecessary for cardiac function exams. In order to make these reconstructions possible in a clinically acceptable timeframe, they will be implemented on a GPU platform, which will reduce the reconstruction time from minutes to seconds. In the independent phase of the project, the GPU platform will be exploited in order to investigate different constrained reconstruction methods for MRI data. In addition to parallel imaging and non-Cartesian acquisitions, these techniques which include compressed sensing have also emerged as a new and important category of possible fast imaging methods. Early work has demonstrated an up to 20-fold reduction in data, and thus time, needed for an image. The power of these methods is obvious, although it is not yet clear if they will be viable in a clinical setting, due to, for instance, incredibly long computation times (sometimes up to days). Thus based on our experience in the first stage of this proposal, the independent portion of this project will explore the potential of these constrained reconstruction methods and examines the possibility of combining them with the non- Cartesian parallel imaging methods developed in the earlier phase. The rapid computational platform, in the form of the GPU implementations, will allow these novel image reconstruction techniques to be vigorously tested, paving the way for these methods to become practical for widespread clinical use.

Public Health Relevance

While magnetic resonance imaging (MRI) is in widespread clinical use because of its sensitivity to a broad range of diseases, the relatively slow acquisition of MRI data limits its applicability to many dynamic imaging situations such as cardiac imaging or MR angiography. The goal of this project is to develop image reconstruction techniques for ultra-fast MRI imaging using a combination of novel acquisition and signal processing methods. Rapid computing using GPU implementations of these techniques will allow the reconstructions to take place in a matter of seconds, allowing this technology to be implemented in a clinical setting. These methods will revolutionize the acquisition and reconstruction of dynamic MRI data.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Transition Award (R00)
Project #
5R00EB011527-05
Application #
8596817
Study Section
Special Emphasis Panel (NSS)
Program Officer
Liu, Guoying
Project Start
2010-03-01
Project End
2014-12-31
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
5
Fiscal Year
2014
Total Cost
$220,408
Indirect Cost
$75,349
Name
Case Western Reserve University
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Saybasili, Haris; Herzka, Daniel A; Seiberlich, Nicole et al. (2014) Real-time imaging with radial GRAPPA: Implementation on a heterogeneous architecture for low-latency reconstructions. Magn Reson Imaging 32:747-58
Wright, Katherine L; Lee, Gregory R; Ehses, Philipp et al. (2014) Three-dimensional through-time radial GRAPPA for renal MR angiography. J Magn Reson Imaging 40:864-74
Wright, Katherine L; Hamilton, Jesse I; Griswold, Mark A et al. (2014) Non-Cartesian parallel imaging reconstruction. J Magn Reson Imaging 40:1022-40
Wright, Katherine L; Chen, Yong; Saybasili, Haris et al. (2014) Quantitative high-resolution renal perfusion imaging using 3-dimensional through-time radial generalized autocalibrating partially parallel acquisition. Invest Radiol 49:666-74
Lee, Gregory R; Seiberlich, Nicole; Sunshine, Jeffrey L et al. (2013) Rapid time-resolved magnetic resonance angiography via a multiecho radial trajectory and GraDeS reconstruction. Magn Reson Med 69:346-59