The long-term objective of this research is to use dynamic network-based mathematical models of human migration and HIV transmission dynamics for designing and evaluating HIV prevention interventions, such as the message of concurrency. There are three specific aims of this research project.
The first aim i s to review existing data on migration and HIV in Ghana. This literature review and empirical research will 1) highlight migration patterns and HIV disparities in Ghana 2) emphasize gaps in our knowledge ofthe complex association between migration and HIV transmission, and 3) reveal the limitations of standard crosssectional data collection. The results of this analysis will inform the questionnaire design in the second aim. Thus the second aim of this research is to design and implement a small-scale pilot survey of sexual networks, migration history, and HIV sexual risk behaviors. The PI will also determine the feasibility of collecting HIV biomarkers for HIV for future cross-discipline work.
The third aim i s to develop a mathematical model based on the network sample in order to quantify the impact of migration on the spread of HIV. This pilot modeling work will be the basis of an R01 application toward the end of the ROO grant cycle.

Public Health Relevance

This work hypothesizes that migration may significantly enhance HIV transmission because migration changes the timing and sequence of partnership formation and duration which promotes concurrency. Thus migrants may be a key target for behavioral prevention interventions aimed at reducing HIV acquisition as well as secondary transmission.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Transition Award (R00)
Project #
5R00HD057553-04
Application #
8149971
Study Section
Special Emphasis Panel (NSS)
Program Officer
Newcomer, Susan
Project Start
2008-09-15
Project End
2013-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
4
Fiscal Year
2011
Total Cost
$240,181
Indirect Cost
Name
University of Washington
Department
Miscellaneous
Type
Schools of Arts and Sciences
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Cassels, Susan; Jenness, Samuel M; Biney, Adriana A E et al. (2017) Geographic mobility and potential bridging for sexually transmitted infections in Agbogbloshie, Ghana. Soc Sci Med 184:27-39
Jenness, Samuel M; Goodreau, Steven M; Morris, Martina et al. (2016) Effectiveness of combination packages for HIV-1 prevention in sub-Saharan Africa depends on partnership network structure: a mathematical modelling study. Sex Transm Infect 92:619-624
Jenness, Samuel M; Biney, Adriana A E; Ampofo, William K et al. (2015) Minimal coital dilution in Accra, Ghana. J Acquir Immune Defic Syndr 69:85-91
Khanna, Aditya S; Roberts, Sarah T; Cassels, Susan et al. (2015) Estimating PMTCT's Impact on Heterosexual HIV Transmission: A Mathematical Modeling Analysis. PLoS One 10:e0134271
Huang, Claire E; Cassels, Susan L; Winer, Rachel L (2015) Self-reported sex partner dates for use in measuring concurrent sexual partnerships: correspondence between two assessment methods. Arch Sex Behav 44:873-83
Cassels, Susan; Jenness, Samuel M; Biney, Adriana A E et al. (2014) Migration, sexual networks, and HIV in Agbogbloshie, Ghana. Demogr Res 31:861-888
Cassels, Susan; Jenness, Samuel M; Khanna, Aditya S (2014) Conceptual framework and research methods for migration and HIV transmission dynamics. AIDS Behav 18:2302-13
Katz, David A; Cassels, Susan L; Stekler, Joanne D (2014) Response to the modeling analysis by Katz et al. on the impact of replacing clinic-based HIV tests with home testing among men who have sex with men in Seattle: authors' reply. Sex Transm Dis 41:320
Katz, David A; Cassels, Susan L; Stekler, Joanne D (2014) Replacing clinic-based tests with home-use tests may increase HIV prevalence among Seattle men who have sex with men: evidence from a mathematical model. Sex Transm Dis 41:2-9
Pearson, Cynthia R; Cassels, Susan (2014) Place and sexual partnership transition among young American Indian and Alaska native women. AIDS Behav 18:1443-53

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