The mother-offspring relationship is the key determinant of offspring survival and reproductive success in most mammals, including humans. Understanding the behavioral and proximate means through which matemal behavior Influences offspring success therefore has a long research history but studies are understandably biased towards captive populations. While elegant captive work demonstrates the transmission of maternal behavior and stress physiology across generations, they lack the ful! extent of environmental heterogeneity that is a critical part of the dynamic behavior-physiology-environment axis. This research fills that gap by investigating the interplay between matemal behavior and stress physiology in wild chimpanzees for the first time. In particular, this study integrates an unrivaled 40-year behavioral dataset with new behavioral, physiological, and health data to: 1) investigate the relationship between maternal stress and behavior, 2) investigate the relationship between maternal behavior and offspring health, stress, and development, and 3) test how short-term fitness consequences of maternal behavior act across generations.
These aims will be addressed amorig the chimpanzees at Gombe National Park, the longest, continuous chimpanzee study site in the world. To address these aims, long-term data analysis is paired with new multiple day family follows which include the collection of detailed behavioral data and fecal samples. Fecal samples are used to extract stress hormones, quantify parasite loads, and measure immune function. This approach allows maternal behavior to be linked directly to offspring physiological and health outcomes. The results ofthis study will yield a functional understanding ofthe complex mother-infant relationship and hgw it works across generations;that is, it will parse out which parts ofthe family systern are important in the short-term from those that have long-term consequences for reproductive success. Understanding this in chimpanzees will have direct application to the same topic in humans.

Public Health Relevance

The well-known behavioral and genetic similarities make chimpanzees a particularly excellent human model. Study results will therefore provide valuable and novel results that are relevant for issues that affect human families today, including the vicious cycle of anxiety across generations. It will also inform a positive model for single-parenting;female chimpanzees raise offspring alone without the detriments seen in humans.'

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Transition Award (R00)
Project #
5R00HD057992-05
Application #
8469867
Study Section
Special Emphasis Panel (NSS)
Program Officer
Freund, Lisa S
Project Start
2011-09-01
Project End
2014-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
5
Fiscal Year
2013
Total Cost
$232,756
Indirect Cost
$80,129
Name
George Washington University
Department
Social Sciences
Type
Schools of Arts and Sciences
DUNS #
043990498
City
Washington
State
DC
Country
United States
Zip Code
20052
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Murray, Carson M; Lonsdorf, Elizabeth V; Stanton, Margaret A et al. (2014) Early social exposure in wild chimpanzees: mothers with sons are more gregarious than mothers with daughters. Proc Natl Acad Sci U S A 111:18189-94
Lonsdorf, Elizabeth V; Anderson, Karen E; Stanton, Margaret A et al. (2014) Boy will be boys: sex differences in wild infant chimpanzee social interactions. Anim Behav 88:79-83
Lonsdorf, Elizabeth V; Markham, A Catherine; Heintz, Matthew R et al. (2014) Sex differences in wild chimpanzee behavior emerge during infancy. PLoS One 9:e99099
Murray, Carson M; Heintz, Matthew R; Lonsdorf, Elizabeth V et al. (2013) Validation of a field technique and characterization of fecal glucocorticoid metabolite analysis in wild chimpanzees (Pan troglodytes). Am J Primatol 75:57-64

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