Although DSM-IV and its predecessors follow a categorical, syndromal nosology, It has long been recognized that there is considerable phenotypic overlap across diagnoses. Consequently, recent attention has been increasingly focused on dinnensional, symptom-based approaches toward untangling the pathophysiology of serious mental illness (for example, those with psychotic features). Similarly, the distinction between illness and health is often treated as dichotomous;yet recent evidence suggests that the phenotypic variations associated with psychosis may be informatively examined using dimensional measures applied to non-clinical samples. Unfortunately, there is a paucity of data on the dimensionality of the behavioral phenotypes associated with psychotic and other serious mental illnesses, and even less data seeking to elucidate the biological mechanisms responsible for this variation. Nevertheless, the psychiatric genetics literature to date provides strong suggestions that pathogenic variations do not respect traditional diagnostic boundaries, and may be more strongly associated with specific symptom domains. The proposed research plan aims to elucidate the genetic underpinnings ofthe dimension of psychosis. Specifically, the K99 portion of this project identified several genetic variants that demonstrated association to distinct phenotypes that crossed traditional DSM-IV boundaries in a sample of evaluated test candidate genes for association with dimensions of psychosis in a large, diagnostically heterogeneous sample. The ROO aims to investigate the relation between these genetic variants and dimensions of sub-clinical psychosis in 1,000 subjects derived from a non-clinical sample.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Transition Award (R00)
Project #
5R00MH086756-04
Application #
8311068
Study Section
Special Emphasis Panel (NSS)
Program Officer
Addington, Anjene M
Project Start
2011-07-01
Project End
2014-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
4
Fiscal Year
2012
Total Cost
$246,787
Indirect Cost
$98,120
Name
Feinstein Institute for Medical Research
Department
Type
DUNS #
110565913
City
Manhasset
State
NY
Country
United States
Zip Code
11030
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DeRosse, Pamela; Nitzburg, George C; Kompancaril, Bernie et al. (2014) The relation between childhood maltreatment and psychosis in patients with schizophrenia and non-psychiatric controls. Schizophr Res 155:66-71
Korponay, Cole; Nitzburg, George C; Malhotra, Anil K et al. (2014) POSITIVE AND NEGATIVE SUBCLINICAL SYMPTOMS AND MCCB PERFORMANCE IN NON-PSYCHIATRIC CONTROLS. Schizophr Res Cogn 1:175-179
Peters, Bart D; Ikuta, Toshikazu; DeRosse, Pamela et al. (2014) Age-related differences in white matter tract microstructure are associated with cognitive performance from childhood to adulthood. Biol Psychiatry 75:248-56
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DeRosse, Pamela; Kaplan, Alyson; Burdick, Katherine E et al. (2010) Cannabis use disorders in schizophrenia: effects on cognition and symptoms. Schizophr Res 120:95-100
Burdick, Katherine E; DeRosse, Pamela; Kane, John M et al. (2010) Association of genetic variation in the MET proto-oncogene with schizophrenia and general cognitive ability. Am J Psychiatry 167:436-43