This application describes plans to develop and test a variety of subtypes related to the development of alcohol dependence among male (n=250) and female (n=250) Native Alaskans receiving treatment for alcoholism. The principal goal of the project is the identification of multivariate subtypes among Native Alaskans using several different domains (e.g., psychiatric, biochemical, temperament, neuropsychological) of data. In addition, several unidimensional typologies previously identified in the literature (e.g., gender, psychopathology, Gamma-Delta, etc.) will be examined In relation to the development of alcoholism. The potential moderating effect of several factors (e.g., cognitive style, environmental cultural identification) on the expression of alcohol dependence within subtypes of Native Alaskans and their natural development will also be examined. Further, direct comparisons of the development and expression of alcohol dependence will be made between this sample of alcoholic Native Alaskans and alcoholics surveyed at six different sites in the U.S. The proposed study will take advantage of a standardized methodology (including assessment instruments) and a large scale data set (containing affected and unaffected subjects) collected as part of a nationwide study of alcoholism, the Collaborative Study on the Genetics of Alcoholism (COGA). Similarities and differences in the nature of alcohol dependence among Native Alaskans and the majority population will be identified. Identification of these similarities/differences may have implications for improving treatment technologies, improving current treatments through patient-treatment matching procedures, and the development of improved prevention programs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA010288-05
Application #
2712082
Study Section
Special Emphasis Panel (SRCA (07))
Project Start
1994-09-20
Project End
2000-05-31
Budget Start
1998-06-01
Budget End
2000-05-31
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Connecticut
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Farmington
State
CT
Country
United States
Zip Code
06030
Malcolm, Barris P; Hesselbrock, Michie N; Segal, Bernard (2006) Multiple substance dependence and course of alcoholism among Alaska native men and women. Subst Use Misuse 41:729-41
Silveri, M M; Spear, L P (2004) The effects of NMDA and GABAA pharmacological manipulations on acute and rapid tolerance to ethanol during ontogeny. Alcohol Clin Exp Res 28:884-94
Hesselbrock, Victor M; Hesselbrock, Michie N; Segal, Bernard (2003) Alcohol dependence among Alaskan natives and their health care utilization. Alcohol Clin Exp Res 27:1353-5
Silveri, M M; Spear, L P (2002) The effects of NMDA and GABAA pharmacological manipulations on ethanol sensitivity in immature and mature animals. Alcohol Clin Exp Res 26:449-56
Parks, C A; Hesselbrock, M N; Hesselbrock, V M et al. (2001) Gender and reported health problems in treated alcohol dependent Alaska natives. J Stud Alcohol 62:286-93
Cheslock, S J; Varlinskaya, E I; Silveri, M M et al. (2000) Acute effects of ethanol and the first suckling episode in the newborn rat. Alcohol Clin Exp Res 24:996-1002
Hesselbrock, V M; Segal, B; Hesselbrock, M N (2000) Alcohol dependence among Alaska Natives entering alcoholism treatment: a gender comparison. J Stud Alcohol 61:150-6
Silveri, M M; Spear, L P (1999) Ontogeny of rapid tolerance to the hypnotic effects of ethanol. Alcohol Clin Exp Res 23:1180-4
Segal, B (1999) ADH and ALDH polymorphisms among Alaska Natives entering treatment for alcoholism. Alaska Med 41:9-12, 23
Segal, B (1998) Drinking and drinking-related problems among Alaska natives. Alcohol Health Res World 22:276-80

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