The Oklahoma Family Health Patterns project is an intensive study of psychological, behavioral, and stress reactivity characteristics in healthy young adults with a family history of alcoholism (FH+) with a goal of identifying characteristics that place these persons at elevated risk for the disorder. We have recently identified early life adverse experience (ELA), including physical and sexual abuse and separation from parents, as occurring with disproportionate impact in FH+, and we have shown that ELA accounts for diminished stress reactivity, behavioral impulsivity, and poor mood regulation, all of which are risk factors for alcohol and other substance use disorders. The impact of ELA in the FH+ population demands to be studied further in a Gene x Environment interaction given the known positive feedbacks between FH+ and ELA. Our goal is to carry out a G x E interaction study by genotyping our FH x ELA and examining the impact of genotype on the broad range of personal characteristics currently under study in this project.
Aim 1. Examine the differential impact of ELA on psychological and behavioral characteristics of FH+ vs. FH- groups using an expanded sample of volunteers.
Aim 2. Use our larger sample to carry out a Gene x Environment analysis to test specific alleles that are strongly suspected of influencing activity in brain motivational systems, expanding on work we initiated with NIAAA thanks to a supplement to this R01 (AA012207-S1).
Aim 3. Test specific aspects of temperament as endophenotypes linking FH and ELA to behavioral, cognitive, and stress reactivity as aspects of the person's phenotype.
Aim 4. Increase our recruitment base by screening and testing volunteers at a second site, the University of Texas HSC, San Antonio, where we currently conduct our neuroimaging studies. Alcoholism is a costly burden to society, but risk factors for alcoholism are poorly understood. The vast majorities of studies focuses on alcoholic patients but are unable to disentangle preexisting influences from the effects of alcohol intake history. Our high-risk study design can be of value by contrasting FH+ and FH- with regard to environmental contributors and genetic vulnerabilities that contribute to behavioral risk factors.

Public Health Relevance

Alcoholism is a costly burden to society, but risk factors for alcoholism are poorly understood. The vast majorities of studies focus on alcoholic patients but are unable to disentangle preexisting influences from the effects of alcohol intake history. Our high-risk study design can be of value by contrasting FH+ and FH- with regard to environmental contributors and genetic vulnerabilities that contribute to behavioral risk factors.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
2R01AA012207-11
Application #
8654480
Study Section
Special Emphasis Panel (ZRG1-BBBP-D (02))
Program Officer
Matochik, John A
Project Start
2001-09-30
Project End
2019-04-30
Budget Start
2014-05-05
Budget End
2015-04-30
Support Year
11
Fiscal Year
2014
Total Cost
$552,647
Indirect Cost
$70,963
Name
University of Oklahoma Health Sciences Center
Department
Psychiatry
Type
Schools of Medicine
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117
Acheson, Ashley; Franklin, Crystal; Cohoon, Andrew J et al. (2014) Anomalous temporoparietal activity in individuals with a family history of alcoholism: studies from the Oklahoma Family Health Patterns Project. Alcohol Clin Exp Res 38:1639-45
Acheson, Ashley; Wijtenburg, S Andrea; Rowland, Laura M et al. (2014) Assessment of whole brain white matter integrity in youths and young adults with a family history of substance-use disorders. Hum Brain Mapp 35:5401-13
Lovallo, William R; Enoch, Mary-Anne; Yechiam, Eldad et al. (2014) Differential impact of serotonin transporter activity on temperament and behavior in persons with a family history of alcoholism in the Oklahoma Family Health Patterns Project. Alcohol Clin Exp Res 38:1575-81
Lovallo, William R; Farag, Noha H; Sorocco, Kristen H et al. (2013) Early life adversity contributes to impaired cognition and impulsive behavior: studies from the Oklahoma Family Health Patterns Project. Alcohol Clin Exp Res 37:616-23
Roche, Daniel J O; King, Andrea C; Cohoon, Andrew J et al. (2013) Hormonal contraceptive use diminishes salivary cortisol response to psychosocial stress and naltrexone in healthy women. Pharmacol Biochem Behav 109:84-90
Lovallo, William R; Farag, Noha H; Sorocco, Kristen H et al. (2012) Lifetime adversity leads to blunted stress axis reactivity: studies from the Oklahoma Family Health Patterns Project. Biol Psychiatry 71:344-9
Acheson, Ashley; Vincent, Andrea S; Sorocco, Kristen H et al. (2011) Greater discounting of delayed rewards in young adults with family histories of alcohol and drug use disorders: studies from the Oklahoma family health patterns project. Alcohol Clin Exp Res 35:1607-13
Lovallo, William R (2011) Do low levels of stress reactivity signal poor states of health? Biol Psychol 86:121-8
Lovallo, William R; Robinson, Jennifer L; Glahn, David C et al. (2010) Acute effects of hydrocortisone on the human brain: an fMRI study. Psychoneuroendocrinology 35:15-20
Sorocco, Kristen H; Monnot, Marilee; Vincent, Andrea S et al. (2010) Deficits in affective prosody comprehension: family history of alcoholism versus alcohol exposure. Alcohol Alcohol 45:25-9

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